The University of Southampton
University of Southampton Institutional Repository

The latest treatment options for bladder cancer

The latest treatment options for bladder cancer
The latest treatment options for bladder cancer

Introduction: bladder cancer carries a high healthcare burden and a poor prognosis once distant metastatic spread has occurred.

Sources of data: we utilised a PubMed/MEDLINE literature search using the terms bladder cancer, chemotherapy, immunotherapy, intra-vesical therapy, surgery and radiotherapy, and current clinical management guidelines (Association of Cancer Physicians, British Association of Urological Surgeons, National Institute for Health and Care Excellence, European Association of Urology).

Areas of agreement: optimal bladder cancer management requires a multi-modal approach incorporating surgery, radiotherapy, chemotherapy and immunotherapy.

Areas of controversy: selection criteria for radical surgery, or radiotherapy as a bladder sparing option, and their relative efficacy, remains poorly defined.

Growing points: palliative immunotherapy has been recently established for advanced bladder cancer after prior chemotherapy. Earlier use is under investigation.

Areas timely for developing research: validated predictive biomarkers, potentially from easily repeatable sites ('liquid biopsies'), will be required to optimise use of molecularly targeted treatment options.

Journal Article
0007-1420
85-95
Crabb, Simon J.
bcd1b566-7677-4f81-8429-3ab0e85f8373
Douglas, James
113c1170-c37f-46bc-9d1c-38843b080abe
Crabb, Simon J.
bcd1b566-7677-4f81-8429-3ab0e85f8373
Douglas, James
113c1170-c37f-46bc-9d1c-38843b080abe

Crabb, Simon J. and Douglas, James (2018) The latest treatment options for bladder cancer. British Medical Bulletin, 128 (1), 85-95. (doi:10.1093/bmb/ldy034).

Record type: Article

Abstract

Introduction: bladder cancer carries a high healthcare burden and a poor prognosis once distant metastatic spread has occurred.

Sources of data: we utilised a PubMed/MEDLINE literature search using the terms bladder cancer, chemotherapy, immunotherapy, intra-vesical therapy, surgery and radiotherapy, and current clinical management guidelines (Association of Cancer Physicians, British Association of Urological Surgeons, National Institute for Health and Care Excellence, European Association of Urology).

Areas of agreement: optimal bladder cancer management requires a multi-modal approach incorporating surgery, radiotherapy, chemotherapy and immunotherapy.

Areas of controversy: selection criteria for radical surgery, or radiotherapy as a bladder sparing option, and their relative efficacy, remains poorly defined.

Growing points: palliative immunotherapy has been recently established for advanced bladder cancer after prior chemotherapy. Earlier use is under investigation.

Areas timely for developing research: validated predictive biomarkers, potentially from easily repeatable sites ('liquid biopsies'), will be required to optimise use of molecularly targeted treatment options.

Text
REVISION CLEAN The latest treatment options for bladder cancer - Accepted Manuscript
Download (205kB)

More information

Accepted/In Press date: 4 October 2018
e-pub ahead of print date: 29 October 2018
Published date: 1 December 2018
Keywords: Journal Article

Identifiers

Local EPrints ID: 426148
URI: http://eprints.soton.ac.uk/id/eprint/426148
ISSN: 0007-1420
PURE UUID: f6cdb2c1-496a-47bf-a4aa-533ef41c0918
ORCID for Simon J. Crabb: ORCID iD orcid.org/0000-0003-3521-9064

Catalogue record

Date deposited: 15 Nov 2018 17:30
Last modified: 11 Jul 2024 04:06

Export record

Altmetrics

Contributors

Author: Simon J. Crabb ORCID iD
Author: James Douglas

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×