The latest treatment options for bladder cancer
The latest treatment options for bladder cancer
Introduction: bladder cancer carries a high healthcare burden and a poor prognosis once distant metastatic spread has occurred.
Sources of data: we utilised a PubMed/MEDLINE literature search using the terms bladder cancer, chemotherapy, immunotherapy, intra-vesical therapy, surgery and radiotherapy, and current clinical management guidelines (Association of Cancer Physicians, British Association of Urological Surgeons, National Institute for Health and Care Excellence, European Association of Urology).
Areas of agreement: optimal bladder cancer management requires a multi-modal approach incorporating surgery, radiotherapy, chemotherapy and immunotherapy.
Areas of controversy: selection criteria for radical surgery, or radiotherapy as a bladder sparing option, and their relative efficacy, remains poorly defined.
Growing points: palliative immunotherapy has been recently established for advanced bladder cancer after prior chemotherapy. Earlier use is under investigation.
Areas timely for developing research: validated predictive biomarkers, potentially from easily repeatable sites ('liquid biopsies'), will be required to optimise use of molecularly targeted treatment options.
Journal Article
85-95
Crabb, Simon J.
bcd1b566-7677-4f81-8429-3ab0e85f8373
Douglas, James
33e87e91-78cf-46ed-8ea1-9000b0649685
1 December 2018
Crabb, Simon J.
bcd1b566-7677-4f81-8429-3ab0e85f8373
Douglas, James
33e87e91-78cf-46ed-8ea1-9000b0649685
Crabb, Simon J. and Douglas, James
(2018)
The latest treatment options for bladder cancer.
British Medical Bulletin, 128 (1), .
(doi:10.1093/bmb/ldy034).
Abstract
Introduction: bladder cancer carries a high healthcare burden and a poor prognosis once distant metastatic spread has occurred.
Sources of data: we utilised a PubMed/MEDLINE literature search using the terms bladder cancer, chemotherapy, immunotherapy, intra-vesical therapy, surgery and radiotherapy, and current clinical management guidelines (Association of Cancer Physicians, British Association of Urological Surgeons, National Institute for Health and Care Excellence, European Association of Urology).
Areas of agreement: optimal bladder cancer management requires a multi-modal approach incorporating surgery, radiotherapy, chemotherapy and immunotherapy.
Areas of controversy: selection criteria for radical surgery, or radiotherapy as a bladder sparing option, and their relative efficacy, remains poorly defined.
Growing points: palliative immunotherapy has been recently established for advanced bladder cancer after prior chemotherapy. Earlier use is under investigation.
Areas timely for developing research: validated predictive biomarkers, potentially from easily repeatable sites ('liquid biopsies'), will be required to optimise use of molecularly targeted treatment options.
Text
REVISION CLEAN The latest treatment options for bladder cancer
- Accepted Manuscript
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Accepted/In Press date: 4 October 2018
e-pub ahead of print date: 29 October 2018
Published date: 1 December 2018
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Journal Article
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Local EPrints ID: 426148
URI: http://eprints.soton.ac.uk/id/eprint/426148
ISSN: 0007-1420
PURE UUID: f6cdb2c1-496a-47bf-a4aa-533ef41c0918
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Date deposited: 15 Nov 2018 17:30
Last modified: 16 Mar 2024 07:16
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Author:
James Douglas
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