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General cognitive, executive and memory function in children with hypoxic ischaemic encephalopathy (HIE) who underwent hypothermia treatment

General cognitive, executive and memory function in children with hypoxic ischaemic encephalopathy (HIE) who underwent hypothermia treatment
General cognitive, executive and memory function in children with hypoxic ischaemic encephalopathy (HIE) who underwent hypothermia treatment
Background and Aims: Despite the introduction of hypothermia treatment (HT), children with neonatalhypoxic-ischemic encephalopathy (HIE) HIE are at increased risk of severe neuromotor impairment (Cerebral Palsy, CP) and developmental impairment.Information on school-age outcomes in the substantial proportion who survive without CP is limited. Here we report preliminary findings.
Method:Thirty-one children admitted to University Hospital Southampton for HT who survived without major neuromotor impairment were assessed at 4 years(y) 9 months(m) - 6y and 8m (mean age 5y4m, SD: 0.37m); mean gestational age 40.20 weeks (SD 1.20), mean birthweight 3465g (SD 704.83).General cognition was assessed using Wechsler Preschool & Primary Scale of Intelligence (WPSSI-IV). Executive Functions (EF) by the Auditory Attention and Inhibition (AAI) NEPSY tasks, and everyday memory with the Rivermead Behavioural Memory Test Children (RBMT-C).
Results: Mean FSIQ for the HIE children was within the norm (Mean 95 SD=13.7). However, 38.4% had FSIQ score below average. AAI mean scores were in the average range ;- but 20.8% were at borderline and below expected level. Over 50% were borderline or impaired on RBMT-C (Mean=14.3, SD=2.9).
Conclusion: Children with a history of neonatal HIE without CP are understudied, and frequently discharged from follow-up at 2 years. Most studies focus on early developmental outcomes. Our preliminary results indicate they are at risk for clinically significant difficulties in areas important for school readiness and learning, particularly everyday memory.
Cianfaglione, Rina
bf9b4507-4a79-4f72-b7e2-7244b9dea9ef
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Edmonds, Caroline
a9af5cbf-e15b-4935-9f85-9022594dd78f
Cianfaglione, Rina
bf9b4507-4a79-4f72-b7e2-7244b9dea9ef
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Edmonds, Caroline
a9af5cbf-e15b-4935-9f85-9022594dd78f

Cianfaglione, Rina, Vollmer, Brigitte and Edmonds, Caroline (2018) General cognitive, executive and memory function in children with hypoxic ischaemic encephalopathy (HIE) who underwent hypothermia treatment. European Academy of Paediatric Societies, Palais des congres de Paris, Paris, France. 30 Oct - 03 Nov 2018.

Record type: Conference or Workshop Item (Poster)

Abstract

Background and Aims: Despite the introduction of hypothermia treatment (HT), children with neonatalhypoxic-ischemic encephalopathy (HIE) HIE are at increased risk of severe neuromotor impairment (Cerebral Palsy, CP) and developmental impairment.Information on school-age outcomes in the substantial proportion who survive without CP is limited. Here we report preliminary findings.
Method:Thirty-one children admitted to University Hospital Southampton for HT who survived without major neuromotor impairment were assessed at 4 years(y) 9 months(m) - 6y and 8m (mean age 5y4m, SD: 0.37m); mean gestational age 40.20 weeks (SD 1.20), mean birthweight 3465g (SD 704.83).General cognition was assessed using Wechsler Preschool & Primary Scale of Intelligence (WPSSI-IV). Executive Functions (EF) by the Auditory Attention and Inhibition (AAI) NEPSY tasks, and everyday memory with the Rivermead Behavioural Memory Test Children (RBMT-C).
Results: Mean FSIQ for the HIE children was within the norm (Mean 95 SD=13.7). However, 38.4% had FSIQ score below average. AAI mean scores were in the average range ;- but 20.8% were at borderline and below expected level. Over 50% were borderline or impaired on RBMT-C (Mean=14.3, SD=2.9).
Conclusion: Children with a history of neonatal HIE without CP are understudied, and frequently discharged from follow-up at 2 years. Most studies focus on early developmental outcomes. Our preliminary results indicate they are at risk for clinically significant difficulties in areas important for school readiness and learning, particularly everyday memory.

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EAPS8_1385
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More information

Accepted/In Press date: 2018
Published date: 30 October 2018
Venue - Dates: European Academy of Paediatric Societies, Palais des congres de Paris, Paris, France, 2018-10-30 - 2018-11-03

Identifiers

Local EPrints ID: 426465
URI: http://eprints.soton.ac.uk/id/eprint/426465
PURE UUID: 88bd98bf-0069-42fc-bbaf-ea3efc7de5e0
ORCID for Rina Cianfaglione: ORCID iD orcid.org/0000-0001-8739-0598
ORCID for Brigitte Vollmer: ORCID iD orcid.org/0000-0003-4088-5336

Catalogue record

Date deposited: 28 Nov 2018 17:30
Last modified: 22 Nov 2021 03:15

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Contributors

Author: Caroline Edmonds

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