The University of Southampton
University of Southampton Institutional Repository

Oscillometric central blood pressure and central systolic loading in stroke patients: Short-Term reproducibility and effects of posture and fasting state

Oscillometric central blood pressure and central systolic loading in stroke patients: Short-Term reproducibility and effects of posture and fasting state
Oscillometric central blood pressure and central systolic loading in stroke patients: Short-Term reproducibility and effects of posture and fasting state

Background This study examined the short-Term reproducibility of non-invasive estimates of central and peripheral blood pressure and markers of central systolic loading (augmentation index [AIx; a measure of central systolic loading] and AIx75 [AIx standardised to 75 b ·min-1 heart rate]) and the effect of posture and fasting state on these variables in patients with acute stroke. Methods Twenty-Two acute stroke patients (72 ± 10y) had blood pressure measured using the SphygmoCor XCEL in supine and seated postures and whilst fasted and non-fasted. Results Acceptable short-Term reproducibility (ICC >0.75) was reported for all peripheral and central variables in all conditions (ICC = 0.77-0.90) and for AIx and AIx75 in both fasted postures (ICC = 0.78-0.81). Food consumption significantly lowered all blood pressures (p <0.05; η2; p = 0.20-0.55). The seated posture resulted in a significantly greater AIx than supine (p <0.05; η2; p = 0.22). Fasting state had significant main effects on AIx and AIx75 (p <0.05; η2; p = 0.14-0.22). Conslusions Oscillometric estimates of central blood pressure have high short-Term reproducibility in different postures and fasting states but markers of systolic load should be assessed whilst fasted. Fasting state has a large effect on central and peripheral blood pressures and on measures of systolic loading. It is important for clinicians to be aware of optimal assessment conditions without this impacting on patient wellbeing. Trial registration Clinical trial registry name: NCT02537652.

1932-6203
Mitchelmore, Andrew
05be4f15-27a1-4b78-be82-2d10fe7c36d1
Stoner, Lee
74b33a10-fc29-47a9-bc86-675d77fa77ac
Lambrick, Danielle
1deafa4b-acf3-4eff-83c9-f8274e47e993
Sykes, Lucy
1b5546cb-089c-4376-b66b-6e5f87484dd0
Eglinton, Charlotte
e5341a28-2ce3-4356-bc92-dfadada6348e
Jobson, Simon
708be525-2bdb-43a0-a6ee-1dd666347611
Faulkner, James
caa8b9e2-f286-4b3f-9017-3db3ffddd7d2
Mitchelmore, Andrew
05be4f15-27a1-4b78-be82-2d10fe7c36d1
Stoner, Lee
74b33a10-fc29-47a9-bc86-675d77fa77ac
Lambrick, Danielle
1deafa4b-acf3-4eff-83c9-f8274e47e993
Sykes, Lucy
1b5546cb-089c-4376-b66b-6e5f87484dd0
Eglinton, Charlotte
e5341a28-2ce3-4356-bc92-dfadada6348e
Jobson, Simon
708be525-2bdb-43a0-a6ee-1dd666347611
Faulkner, James
caa8b9e2-f286-4b3f-9017-3db3ffddd7d2

Mitchelmore, Andrew, Stoner, Lee, Lambrick, Danielle, Sykes, Lucy, Eglinton, Charlotte, Jobson, Simon and Faulkner, James (2018) Oscillometric central blood pressure and central systolic loading in stroke patients: Short-Term reproducibility and effects of posture and fasting state. PLoS ONE, 13 (11), [e0206329]. (doi:10.1371/journal.pone.0206329).

Record type: Article

Abstract

Background This study examined the short-Term reproducibility of non-invasive estimates of central and peripheral blood pressure and markers of central systolic loading (augmentation index [AIx; a measure of central systolic loading] and AIx75 [AIx standardised to 75 b ·min-1 heart rate]) and the effect of posture and fasting state on these variables in patients with acute stroke. Methods Twenty-Two acute stroke patients (72 ± 10y) had blood pressure measured using the SphygmoCor XCEL in supine and seated postures and whilst fasted and non-fasted. Results Acceptable short-Term reproducibility (ICC >0.75) was reported for all peripheral and central variables in all conditions (ICC = 0.77-0.90) and for AIx and AIx75 in both fasted postures (ICC = 0.78-0.81). Food consumption significantly lowered all blood pressures (p <0.05; η2; p = 0.20-0.55). The seated posture resulted in a significantly greater AIx than supine (p <0.05; η2; p = 0.22). Fasting state had significant main effects on AIx and AIx75 (p <0.05; η2; p = 0.14-0.22). Conslusions Oscillometric estimates of central blood pressure have high short-Term reproducibility in different postures and fasting states but markers of systolic load should be assessed whilst fasted. Fasting state has a large effect on central and peripheral blood pressures and on measures of systolic loading. It is important for clinicians to be aware of optimal assessment conditions without this impacting on patient wellbeing. Trial registration Clinical trial registry name: NCT02537652.

Text
journal.pone.0206329 - Version of Record
Available under License Creative Commons Attribution.
Download (731kB)

More information

Accepted/In Press date: 5 October 2018
e-pub ahead of print date: 1 November 2018
Published date: 1 November 2018

Identifiers

Local EPrints ID: 426500
URI: http://eprints.soton.ac.uk/id/eprint/426500
ISSN: 1932-6203
PURE UUID: 58615d2f-627e-40de-8ecd-df533b544630
ORCID for Danielle Lambrick: ORCID iD orcid.org/0000-0002-0325-6015

Catalogue record

Date deposited: 29 Nov 2018 17:30
Last modified: 06 Jun 2024 01:54

Export record

Altmetrics

Contributors

Author: Andrew Mitchelmore
Author: Lee Stoner
Author: Lucy Sykes
Author: Charlotte Eglinton
Author: Simon Jobson
Author: James Faulkner

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×