Molecular pathways in the development and treatment of oesophageal cancer
Molecular pathways in the development and treatment of oesophageal cancer
The molecular pathways involved in the development and treatment of oesophageal cancer are complex. Recent large-scale genome sequencing studies have delivered novel insights into aetiology and possible targeted treatments. Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct entities. At the molecular level OSCC is more similar to squamous cell cancers in other organs than OAC. Whilst considerable heterogeneity exists in both tumour types new data suggests that driver gene events and mutational signatures may be able to categorise tumours into potentially actionable subtypes. Taken together these findings not only suggest new avenues for treatments in a cancer type with appalling outcomes, but also a new era of molecular rather than purely anatomical classification and staging of oesophageal cancer.
9-15
Walker, Robert Charles
5a7a4629-6996-4975-8ed1-a18614db491b
Underwood, Timothy
8e81bf60-edd2-4b0e-8324-3068c95ea1c6
Walker, Robert Charles
5a7a4629-6996-4975-8ed1-a18614db491b
Underwood, Timothy
8e81bf60-edd2-4b0e-8324-3068c95ea1c6
Walker, Robert Charles and Underwood, Timothy
(2018)
Molecular pathways in the development and treatment of oesophageal cancer.
Best Practice & Research: Clinical Gastroenterology, 36-37, .
(doi:10.1016/j.bpg.2018.11.013).
Abstract
The molecular pathways involved in the development and treatment of oesophageal cancer are complex. Recent large-scale genome sequencing studies have delivered novel insights into aetiology and possible targeted treatments. Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct entities. At the molecular level OSCC is more similar to squamous cell cancers in other organs than OAC. Whilst considerable heterogeneity exists in both tumour types new data suggests that driver gene events and mutational signatures may be able to categorise tumours into potentially actionable subtypes. Taken together these findings not only suggest new avenues for treatments in a cancer type with appalling outcomes, but also a new era of molecular rather than purely anatomical classification and staging of oesophageal cancer.
Text
Molecular Pathways Chapter Final_PP_RA
- Accepted Manuscript
More information
Accepted/In Press date: 20 November 2018
e-pub ahead of print date: 23 November 2018
Identifiers
Local EPrints ID: 426517
URI: http://eprints.soton.ac.uk/id/eprint/426517
ISSN: 1521-6918
PURE UUID: e5a7e8af-52c1-4cf9-8ef3-c4c71ecab412
Catalogue record
Date deposited: 29 Nov 2018 17:30
Last modified: 16 Mar 2024 07:21
Export record
Altmetrics
Contributors
Author:
Robert Charles Walker
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
