The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Pregnancy supplementation of Gambian mothers with calcium carbonate alters mid-childhood IGF1 in a sex-specific manner

Pregnancy supplementation of Gambian mothers with calcium carbonate alters mid-childhood IGF1 in a sex-specific manner
Pregnancy supplementation of Gambian mothers with calcium carbonate alters mid-childhood IGF1 in a sex-specific manner
Context: sex-specific effects of pregnancy calcium carbonate supplementation have been reported in 8–12 year old Gambian children, indicating faster growth in boys but slower growth in girls born to calcium-supplemented mothers.

Objective: to determine whether the pregnancy supplement resulted in sex-specific effects on offspring IGF1 and other growth-related indices in mid-childhood.

Design: analysis of archived data obtained in mid-childhood from the children of rural Gambian mothers who had been randomised to 1500 mgCa/d (Ca) or placebo (P) from 20 weeks pregnancy to delivery (ISRCTN96502494).

Participants and methods: of the 526 children born and followed in infancy, 290 had early-morning, fasting plasma assayed for IGF1, IGFBP3, leptin, insulin and calcium-related indices and had anthropometry performed at age 7.5 (SD1.2) years (N/group: Males(M)-Ca = 64, Females(F)-Ca = 77; M-P = 76, F-P = 73). Sex-specific effects of maternal supplementation were considered using regression with sexes separated and together to test for sex ∗ supplement interactions.

Results: boys had lower IGF1, IGFBP3, leptin and insulin than girls (P ≤ 0.004). IGF1 was higher in M-Ca than M-P (+14.2 (SE7.7)%, P = 0.05) but lower in F-Ca than F-P (−17.8 (SE7.4)%, P = 0.01); sex ∗ supplement interaction P = 0.001. IGF1 concentrations (ng/ml, geometric mean [−1SE,+1SE]) were M-Ca = 78.1[4.3,4.5], M-P = 67.8[3.4,3.6]; F-Ca = 99.5[4.8,5.1], F-P = 118.9[6.4,6.8]. Similar sex ∗ supplement interactions were seen for IGFBP3 and IGF1-adjusted-for-IGFBP3 but group differences were smaller. There were no significant supplement effects on the other biochemical indices.

Conclusions: calcium carbonate supplementation of pregnant Gambian mothers resulted in higher IGF1 in boys and lower IGF1 in girls during mid-childhood, consistent with the reported maternal supplement effects on growth of the offspring in later childhood.
8756-3282
314-320
Prentice, Ann
675810ad-8022-453c-b3a3-8afff0e1a920
Ward, Kathryn
39bd4db1-c948-4e32-930e-7bec8deb54c7
Nigdikar, Shailja
92da9792-1b27-4333-91a2-e4443936409c
Hawkesworth, Sophie
570d96e4-e036-432c-98af-7ee4cbd7bfc6
Moore, Sophie E.
bea65f65-3f11-45cd-96d2-c088a18ccc55
Prentice, Ann
675810ad-8022-453c-b3a3-8afff0e1a920
Ward, Kathryn
39bd4db1-c948-4e32-930e-7bec8deb54c7
Nigdikar, Shailja
92da9792-1b27-4333-91a2-e4443936409c
Hawkesworth, Sophie
570d96e4-e036-432c-98af-7ee4cbd7bfc6
Moore, Sophie E.
bea65f65-3f11-45cd-96d2-c088a18ccc55

Prentice, Ann, Ward, Kathryn, Nigdikar, Shailja, Hawkesworth, Sophie and Moore, Sophie E. (2019) Pregnancy supplementation of Gambian mothers with calcium carbonate alters mid-childhood IGF1 in a sex-specific manner. Bone, 120, 314-320. (doi:10.1016/j.bone.2018.11.011).

Record type: Article

Abstract

Context: sex-specific effects of pregnancy calcium carbonate supplementation have been reported in 8–12 year old Gambian children, indicating faster growth in boys but slower growth in girls born to calcium-supplemented mothers.

Objective: to determine whether the pregnancy supplement resulted in sex-specific effects on offspring IGF1 and other growth-related indices in mid-childhood.

Design: analysis of archived data obtained in mid-childhood from the children of rural Gambian mothers who had been randomised to 1500 mgCa/d (Ca) or placebo (P) from 20 weeks pregnancy to delivery (ISRCTN96502494).

Participants and methods: of the 526 children born and followed in infancy, 290 had early-morning, fasting plasma assayed for IGF1, IGFBP3, leptin, insulin and calcium-related indices and had anthropometry performed at age 7.5 (SD1.2) years (N/group: Males(M)-Ca = 64, Females(F)-Ca = 77; M-P = 76, F-P = 73). Sex-specific effects of maternal supplementation were considered using regression with sexes separated and together to test for sex ∗ supplement interactions.

Results: boys had lower IGF1, IGFBP3, leptin and insulin than girls (P ≤ 0.004). IGF1 was higher in M-Ca than M-P (+14.2 (SE7.7)%, P = 0.05) but lower in F-Ca than F-P (−17.8 (SE7.4)%, P = 0.01); sex ∗ supplement interaction P = 0.001. IGF1 concentrations (ng/ml, geometric mean [−1SE,+1SE]) were M-Ca = 78.1[4.3,4.5], M-P = 67.8[3.4,3.6]; F-Ca = 99.5[4.8,5.1], F-P = 118.9[6.4,6.8]. Similar sex ∗ supplement interactions were seen for IGFBP3 and IGF1-adjusted-for-IGFBP3 but group differences were smaller. There were no significant supplement effects on the other biochemical indices.

Conclusions: calcium carbonate supplementation of pregnant Gambian mothers resulted in higher IGF1 in boys and lower IGF1 in girls during mid-childhood, consistent with the reported maternal supplement effects on growth of the offspring in later childhood.

Text
BONE-D-18-00768R1-2 - Accepted Manuscript
Download (770kB)
Text
Pregnancy supplementation of Gambian - Version of Record
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 17 November 2018
e-pub ahead of print date: 19 November 2018
Published date: March 2019

Identifiers

Local EPrints ID: 426519
URI: http://eprints.soton.ac.uk/id/eprint/426519
ISSN: 8756-3282
PURE UUID: 8fc57598-e52f-44f9-b64f-f36954eb182d
ORCID for Kathryn Ward: ORCID iD orcid.org/0000-0001-7034-6750

Catalogue record

Date deposited: 29 Nov 2018 17:30
Last modified: 22 Nov 2021 06:59

Export record

Altmetrics

Contributors

Author: Ann Prentice
Author: Kathryn Ward ORCID iD
Author: Shailja Nigdikar
Author: Sophie Hawkesworth
Author: Sophie E. Moore

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×