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Magnetic interaction of multifunctional core–shell nanoparticles for highly effective theranostics

Magnetic interaction of multifunctional core–shell nanoparticles for highly effective theranostics
Magnetic interaction of multifunctional core–shell nanoparticles for highly effective theranostics

The controlled size and surface treatment of magnetic nanoparticles (NPs) make one-stage combination feasible for enhanced magnetic resonance imaging (MRI) contrast and effective hyperthermia. However, superparamagnetic behavior, essential for avoiding the aggregation of magnetic NPs, substantially limits their performance. Here, a superparamagnetic core–shell structure is developed, which promotes the formation of vortex-like intraparticle magnetization structures in the remanent state, leading to reduced dipolar interactions between two neighboring NPs, while during an MRI scan, the presence of a DC magnetic field induces the formation of NP chains, introducing increased local inhomogeneous dipole fields that enhance relaxivity. The core–shell NPs also reveal an augmented anisotropy, due to exchange coupling to the high anisotropy core, which enhances the specific absorption rate. This in vivo tumor study reveals that the tumor cells can be clearly diagnosed during an MRI scan and the tumor size is substantially reduced through hyperthermia therapy by using the same FePt@iron oxide nanoparticles, realizing the concept of theranostics.

core–shell, hyperthermia, magnetic interaction, magnetic resonance image, theranostics
0935-9648
Yang, Ming Da
5a913fda-feaa-4ebc-b575-3b511ee6e25b
Ho, Chien Hsin
2e7f0348-28d4-41be-8b44-274dc3c27f59
Ruta, Sergiu
47509d6b-adba-44a3-a2d4-1cac17bf8de7
Chantrell, Roy
e302f8d2-4450-4d1e-a944-50f40e93e7db
Krycka, Kathryn
eb15754a-d870-4468-909e-04f919f7e354
Hovorka, Ondrej
a12bd550-ad45-4963-aa26-dd81dd1609ee
Chen, Fu Rong
ee53e6e1-8157-45dc-9c99-522669f23550
Lai, Ping Shan
0fd4c943-6de7-4622-975c-b565385da543
Lai, Chih Huang
9380ed24-c014-4468-9704-bf97353c1e6c
Yang, Ming Da
5a913fda-feaa-4ebc-b575-3b511ee6e25b
Ho, Chien Hsin
2e7f0348-28d4-41be-8b44-274dc3c27f59
Ruta, Sergiu
47509d6b-adba-44a3-a2d4-1cac17bf8de7
Chantrell, Roy
e302f8d2-4450-4d1e-a944-50f40e93e7db
Krycka, Kathryn
eb15754a-d870-4468-909e-04f919f7e354
Hovorka, Ondrej
a12bd550-ad45-4963-aa26-dd81dd1609ee
Chen, Fu Rong
ee53e6e1-8157-45dc-9c99-522669f23550
Lai, Ping Shan
0fd4c943-6de7-4622-975c-b565385da543
Lai, Chih Huang
9380ed24-c014-4468-9704-bf97353c1e6c

Yang, Ming Da, Ho, Chien Hsin, Ruta, Sergiu, Chantrell, Roy, Krycka, Kathryn, Hovorka, Ondrej, Chen, Fu Rong, Lai, Ping Shan and Lai, Chih Huang (2018) Magnetic interaction of multifunctional core–shell nanoparticles for highly effective theranostics. Advanced Materials, 30 (50), [1802444]. (doi:10.1002/adma.201802444).

Record type: Article

Abstract

The controlled size and surface treatment of magnetic nanoparticles (NPs) make one-stage combination feasible for enhanced magnetic resonance imaging (MRI) contrast and effective hyperthermia. However, superparamagnetic behavior, essential for avoiding the aggregation of magnetic NPs, substantially limits their performance. Here, a superparamagnetic core–shell structure is developed, which promotes the formation of vortex-like intraparticle magnetization structures in the remanent state, leading to reduced dipolar interactions between two neighboring NPs, while during an MRI scan, the presence of a DC magnetic field induces the formation of NP chains, introducing increased local inhomogeneous dipole fields that enhance relaxivity. The core–shell NPs also reveal an augmented anisotropy, due to exchange coupling to the high anisotropy core, which enhances the specific absorption rate. This in vivo tumor study reveals that the tumor cells can be clearly diagnosed during an MRI scan and the tumor size is substantially reduced through hyperthermia therapy by using the same FePt@iron oxide nanoparticles, realizing the concept of theranostics.

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More information

Accepted/In Press date: 1 January 2018
e-pub ahead of print date: 11 October 2018
Published date: 13 December 2018
Keywords: core–shell, hyperthermia, magnetic interaction, magnetic resonance image, theranostics

Identifiers

Local EPrints ID: 426521
URI: http://eprints.soton.ac.uk/id/eprint/426521
ISSN: 0935-9648
PURE UUID: e1c1a964-f420-40e4-afc7-8fc11b365638
ORCID for Ondrej Hovorka: ORCID iD orcid.org/0000-0002-6707-4325

Catalogue record

Date deposited: 29 Nov 2018 17:30
Last modified: 06 Jun 2024 04:13

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Contributors

Author: Ming Da Yang
Author: Chien Hsin Ho
Author: Sergiu Ruta
Author: Roy Chantrell
Author: Kathryn Krycka
Author: Ondrej Hovorka ORCID iD
Author: Fu Rong Chen
Author: Ping Shan Lai
Author: Chih Huang Lai

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