Mammalian sperm contain two factors for calcium release and egg activation: phospholipase C zeta and a cryptic activating factor
Mammalian sperm contain two factors for calcium release and egg activation: phospholipase C zeta and a cryptic activating factor
Mammalian sperm induce a series of calcium oscillations in the egg at fertilization responsible for triggering the transition to a 1-cell embryo and for blocking polyspermy. Phospholipase C (PLC) zeta is a sperm-specific protein capable of mimicking these fertilization calcium changes through its ability to generate inositol trisphosphate. Here I comment on two recent landmark studies that report on knockout of PLC zeta in mice. Both demonstrate the importance of PLC zeta in generating a regular pattern of calcium oscillations and how eggs become highly polyspermic in its absence.
465-468
Jones, Keith T.
73e8e2b5-cd67-4691-b1a9-4e7bc9066af4
1 October 2018
Jones, Keith T.
73e8e2b5-cd67-4691-b1a9-4e7bc9066af4
Jones, Keith T.
(2018)
Mammalian sperm contain two factors for calcium release and egg activation: phospholipase C zeta and a cryptic activating factor.
Molecular Human Reproduction, 24 (10), .
(doi:10.1093/molehr/gay038).
Abstract
Mammalian sperm induce a series of calcium oscillations in the egg at fertilization responsible for triggering the transition to a 1-cell embryo and for blocking polyspermy. Phospholipase C (PLC) zeta is a sperm-specific protein capable of mimicking these fertilization calcium changes through its ability to generate inositol trisphosphate. Here I comment on two recent landmark studies that report on knockout of PLC zeta in mice. Both demonstrate the importance of PLC zeta in generating a regular pattern of calcium oscillations and how eggs become highly polyspermic in its absence.
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Accepted/In Press date: 22 August 2018
e-pub ahead of print date: 23 August 2018
Published date: 1 October 2018
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Local EPrints ID: 426577
URI: http://eprints.soton.ac.uk/id/eprint/426577
ISSN: 1360-9947
PURE UUID: 416ac632-7c0b-4c34-beb6-cc423bc8773e
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Date deposited: 30 Nov 2018 17:30
Last modified: 15 Mar 2024 22:12
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Author:
Keith T. Jones
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