The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Mammalian sperm contain two factors for calcium release and egg activation: phospholipase C zeta and a cryptic activating factor

Mammalian sperm contain two factors for calcium release and egg activation: phospholipase C zeta and a cryptic activating factor
Mammalian sperm contain two factors for calcium release and egg activation: phospholipase C zeta and a cryptic activating factor
Mammalian sperm induce a series of calcium oscillations in the egg at fertilization responsible for triggering the transition to a 1-cell embryo and for blocking polyspermy. Phospholipase C (PLC) zeta is a sperm-specific protein capable of mimicking these fertilization calcium changes through its ability to generate inositol trisphosphate. Here I comment on two recent landmark studies that report on knockout of PLC zeta in mice. Both demonstrate the importance of PLC zeta in generating a regular pattern of calcium oscillations and how eggs become highly polyspermic in its absence.
1360-9947
465-468
Jones, Keith T.
73e8e2b5-cd67-4691-b1a9-4e7bc9066af4
Jones, Keith T.
73e8e2b5-cd67-4691-b1a9-4e7bc9066af4

Jones, Keith T. (2018) Mammalian sperm contain two factors for calcium release and egg activation: phospholipase C zeta and a cryptic activating factor. Molecular Human Reproduction, 24 (10), 465-468. (doi:10.1093/molehr/gay038).

Record type: Review

Abstract

Mammalian sperm induce a series of calcium oscillations in the egg at fertilization responsible for triggering the transition to a 1-cell embryo and for blocking polyspermy. Phospholipase C (PLC) zeta is a sperm-specific protein capable of mimicking these fertilization calcium changes through its ability to generate inositol trisphosphate. Here I comment on two recent landmark studies that report on knockout of PLC zeta in mice. Both demonstrate the importance of PLC zeta in generating a regular pattern of calcium oscillations and how eggs become highly polyspermic in its absence.

This record has no associated files available for download.

More information

Accepted/In Press date: 22 August 2018
e-pub ahead of print date: 23 August 2018
Published date: 1 October 2018

Identifiers

Local EPrints ID: 426577
URI: http://eprints.soton.ac.uk/id/eprint/426577
ISSN: 1360-9947
PURE UUID: 416ac632-7c0b-4c34-beb6-cc423bc8773e
ORCID for Keith T. Jones: ORCID iD orcid.org/0000-0002-0294-0851

Catalogue record

Date deposited: 30 Nov 2018 17:30
Last modified: 26 Nov 2021 02:59

Export record

Altmetrics

Contributors

Author: Keith T. Jones ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×