Synthesis and reactivity of N-allenyl cyanamides
Synthesis and reactivity of N-allenyl cyanamides
N-Allenyl cyanamides have been accessed via a one-pot deoxycyanamidation-isomerization approach using propargyl alcohol and N-cyano-N-phenyl-p-methylbenzenesulfonamide. The utility of this novel class of allenamide was explored through derivatization, with hydroarylation, hydroamination, and cycloaddition protocols employed to access an array of cyanamide products that would be challenging to access using existing methods.
5282-5285
Ayres, James N.
cc095fc1-1cd3-43e1-982f-a20556aa2010
Williams, Matthew T.J.
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Tizzard, Graham J.
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Coles, Simon J.
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Ling, Kenneth B.
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Morrill, Louis C.
987789df-0246-46eb-80e0-79075392bb95
7 September 2018
Ayres, James N.
cc095fc1-1cd3-43e1-982f-a20556aa2010
Williams, Matthew T.J.
b0f899a3-e291-4085-9565-b141d79069dc
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Ling, Kenneth B.
054c3460-f666-4bfc-b5fd-7e56009c5522
Morrill, Louis C.
987789df-0246-46eb-80e0-79075392bb95
Ayres, James N., Williams, Matthew T.J., Tizzard, Graham J., Coles, Simon J., Ling, Kenneth B. and Morrill, Louis C.
(2018)
Synthesis and reactivity of N-allenyl cyanamides.
Organic Letters, 20 (17), .
(doi:10.1021/acs.orglett.8b02225).
Abstract
N-Allenyl cyanamides have been accessed via a one-pot deoxycyanamidation-isomerization approach using propargyl alcohol and N-cyano-N-phenyl-p-methylbenzenesulfonamide. The utility of this novel class of allenamide was explored through derivatization, with hydroarylation, hydroamination, and cycloaddition protocols employed to access an array of cyanamide products that would be challenging to access using existing methods.
Text
acs.orglett.8b02225
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e-pub ahead of print date: 14 August 2018
Published date: 7 September 2018
Identifiers
Local EPrints ID: 426586
URI: http://eprints.soton.ac.uk/id/eprint/426586
ISSN: 1523-7060
PURE UUID: 303bb7eb-e74f-47f6-b67a-19cb6d365de4
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Date deposited: 30 Nov 2018 17:30
Last modified: 16 Mar 2024 03:22
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Author:
James N. Ayres
Author:
Matthew T.J. Williams
Author:
Kenneth B. Ling
Author:
Louis C. Morrill
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