Targeting FcRn to generate antibody-based therapeutics
Targeting FcRn to generate antibody-based therapeutics
The MHC class I-related receptor FcRn serves multiple roles ranging from the regulation of levels of IgG isotype antibodies and albumin throughout the body to the delivery of antigen into antigen loading compartments in specialized antigen-presenting cells. In parallel with studies directed towards understanding FcRn at the molecular and cellular levels, there has been an enormous expansion in the development of engineering strategies involving FcRn to modulate the dynamic behavior of antibodies, antigens, and albumin. In this review article, we focus on a discussion of FcRn-targeted approaches that have resulted in the production of novel antibody-based platforms with considerable potential for use in the clinic.
antibody engineering, FcRn, FcRn-targeted therapeutics, pharmacokinetics
892-904
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
October 2018
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
Ward, E. Sally and Ober, Raimund J.
(2018)
Targeting FcRn to generate antibody-based therapeutics.
Trends in Pharmacological Sciences, 39 (10), .
(doi:10.1016/j.tips.2018.07.007).
Abstract
The MHC class I-related receptor FcRn serves multiple roles ranging from the regulation of levels of IgG isotype antibodies and albumin throughout the body to the delivery of antigen into antigen loading compartments in specialized antigen-presenting cells. In parallel with studies directed towards understanding FcRn at the molecular and cellular levels, there has been an enormous expansion in the development of engineering strategies involving FcRn to modulate the dynamic behavior of antibodies, antigens, and albumin. In this review article, we focus on a discussion of FcRn-targeted approaches that have resulted in the production of novel antibody-based platforms with considerable potential for use in the clinic.
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Accepted/In Press date: 27 July 2018
e-pub ahead of print date: 22 August 2018
Published date: October 2018
Keywords:
antibody engineering, FcRn, FcRn-targeted therapeutics, pharmacokinetics
Identifiers
Local EPrints ID: 426598
URI: http://eprints.soton.ac.uk/id/eprint/426598
ISSN: 0165-6147
PURE UUID: d8957d25-5504-4f20-b384-f1d7de1c3cf0
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Date deposited: 30 Nov 2018 17:30
Last modified: 18 Mar 2024 03:48
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