Na+/K+-pump and neurotransmitter membrane receptors
Na+/K+-pump and neurotransmitter membrane receptors
Na+/K+-pump is an electrogenic transmembrane ATPase located in the outer plasma membrane of cells. The Na+/K+-ATPase pumps 3 sodium ions out of cells while pumping 2 potassium ions into cells. Both cations move against their concentration gradients. This enzyme’s electrogenic nature means that it has a chronic role in stabilizing the resting membrane potential of the cell, in regulating the cell volume and in the signal transduction of the cell. This review will mainly consider the role of the Na+/K+-pump in neurons, with an emphasis on its role in modulating neurotransmitter receptor. Most of the literature on the modulation of neurotransmitter receptors refers to the situation in the mammalian nervous system, but the position is likely to be similar in most, if not all, invertebrate nervous systems.
Na/K-pump, Neurotransmitter membrane receptors, Ouabain
1-16
Pivovarov, Arkady S.
efd8efe9-0ce8-42bf-8e51-9660620d0c74
Calahorro, Fernando
dddfa373-d3cc-433f-8851-9ca37f2f3950
Walker, Robert J.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
1 March 2019
Pivovarov, Arkady S.
efd8efe9-0ce8-42bf-8e51-9660620d0c74
Calahorro, Fernando
dddfa373-d3cc-433f-8851-9ca37f2f3950
Walker, Robert J.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Pivovarov, Arkady S., Calahorro, Fernando and Walker, Robert J.
(2019)
Na+/K+-pump and neurotransmitter membrane receptors.
Invertebrate Neuroscience, 19 (1), , [1].
(doi:10.1007/s10158-018-0221-7).
Abstract
Na+/K+-pump is an electrogenic transmembrane ATPase located in the outer plasma membrane of cells. The Na+/K+-ATPase pumps 3 sodium ions out of cells while pumping 2 potassium ions into cells. Both cations move against their concentration gradients. This enzyme’s electrogenic nature means that it has a chronic role in stabilizing the resting membrane potential of the cell, in regulating the cell volume and in the signal transduction of the cell. This review will mainly consider the role of the Na+/K+-pump in neurons, with an emphasis on its role in modulating neurotransmitter receptor. Most of the literature on the modulation of neurotransmitter receptors refers to the situation in the mammalian nervous system, but the position is likely to be similar in most, if not all, invertebrate nervous systems.
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Pivovarov 2018 Article NaK pump And Neurotransmitter Mem
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Accepted/In Press date: 17 November 2018
e-pub ahead of print date: 28 November 2018
Published date: 1 March 2019
Keywords:
Na/K-pump, Neurotransmitter membrane receptors, Ouabain
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Local EPrints ID: 426719
URI: http://eprints.soton.ac.uk/id/eprint/426719
ISSN: 1354-2516
PURE UUID: 882b6e6a-5537-417e-a9e7-b78ac544e6db
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Date deposited: 11 Dec 2018 17:30
Last modified: 16 Mar 2024 04:37
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Author:
Arkady S. Pivovarov
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