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Na+/K+-pump and neurotransmitter membrane receptors

Na+/K+-pump and neurotransmitter membrane receptors
Na+/K+-pump and neurotransmitter membrane receptors

Na+/K+-pump is an electrogenic transmembrane ATPase located in the outer plasma membrane of cells. The Na+/K+-ATPase pumps 3 sodium ions out of cells while pumping 2 potassium ions into cells. Both cations move against their concentration gradients. This enzyme’s electrogenic nature means that it has a chronic role in stabilizing the resting membrane potential of the cell, in regulating the cell volume and in the signal transduction of the cell. This review will mainly consider the role of the Na+/K+-pump in neurons, with an emphasis on its role in modulating neurotransmitter receptor. Most of the literature on the modulation of neurotransmitter receptors refers to the situation in the mammalian nervous system, but the position is likely to be similar in most, if not all, invertebrate nervous systems.

Na/K-pump, Neurotransmitter membrane receptors, Ouabain
1354-2516
1-16
Pivovarov, Arkady S.
efd8efe9-0ce8-42bf-8e51-9660620d0c74
Calahorro, Fernando
dddfa373-d3cc-433f-8851-9ca37f2f3950
Walker, Robert J.
c8fbfe1c-349d-497f-b24e-0295c84c4634
Pivovarov, Arkady S.
efd8efe9-0ce8-42bf-8e51-9660620d0c74
Calahorro, Fernando
dddfa373-d3cc-433f-8851-9ca37f2f3950
Walker, Robert J.
c8fbfe1c-349d-497f-b24e-0295c84c4634

Pivovarov, Arkady S., Calahorro, Fernando and Walker, Robert J. (2019) Na+/K+-pump and neurotransmitter membrane receptors. Invertebrate Neuroscience, 19 (1), 1-16, [1]. (doi:10.1007/s10158-018-0221-7).

Record type: Review

Abstract

Na+/K+-pump is an electrogenic transmembrane ATPase located in the outer plasma membrane of cells. The Na+/K+-ATPase pumps 3 sodium ions out of cells while pumping 2 potassium ions into cells. Both cations move against their concentration gradients. This enzyme’s electrogenic nature means that it has a chronic role in stabilizing the resting membrane potential of the cell, in regulating the cell volume and in the signal transduction of the cell. This review will mainly consider the role of the Na+/K+-pump in neurons, with an emphasis on its role in modulating neurotransmitter receptor. Most of the literature on the modulation of neurotransmitter receptors refers to the situation in the mammalian nervous system, but the position is likely to be similar in most, if not all, invertebrate nervous systems.

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Pivovarov 2018 Article NaK pump And Neurotransmitter Mem - Version of Record
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Accepted/In Press date: 17 November 2018
e-pub ahead of print date: 28 November 2018
Published date: 1 March 2019
Keywords: Na/K-pump, Neurotransmitter membrane receptors, Ouabain

Identifiers

Local EPrints ID: 426719
URI: http://eprints.soton.ac.uk/id/eprint/426719
ISSN: 1354-2516
PURE UUID: 882b6e6a-5537-417e-a9e7-b78ac544e6db
ORCID for Fernando Calahorro: ORCID iD orcid.org/0000-0003-0659-7728

Catalogue record

Date deposited: 11 Dec 2018 17:30
Last modified: 15 Sep 2021 02:00

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Contributors

Author: Arkady S. Pivovarov
Author: Robert J. Walker

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