%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Yujing Shi, Hui Gao, Georgios Pappas, Qiulan Chen, Mei Li, Jun Xu, Shengjie Lai, Qiaohong Liao, Wenwen Yang, Zhongtao Yi, Zulaguli Rouzi, Hongjie Yu
Clinical features of 2041 human brucellosis cases in China
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>
endobj
4 0 obj
<>/XObject<>>>
endobj
6 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref002)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref003)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref005)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref006)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref007)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref008)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref009)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref010)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref011)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref012)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref013)>>
endobj
28 0 obj
<>/Border[0 0 0]/A 29 0 R>>
endobj
29 0 obj
<>
endobj
7 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0.0001 w
576 652.23 m
200 652.23 l
200 652.73 l
576 652.73 l
f*
0.83 0.64 0.02 0 k
447.987 560.013 m
452.75 560.013 l
h
f*
457.172 560.013 m
461.934 560.013 l
h
f*
409.776 534.047 m
414.539 534.047 l
h
f*
419.698 534.047 m
424.46 534.047 l
h
f*
278.816 495.043 m
283.521 495.043 l
h
f*
220.139 456.038 m
224.901 456.038 l
h
f*
511.654 417.033 m
516.416 417.033 l
h
f*
520.838 417.033 m
525.6 417.033 l
h
f*
234.425 365.046 m
243.95 365.046 l
h
f*
274.337 365.046 m
283.861 365.046 l
h
f*
325.134 365.046 m
334.658 365.046 l
h
f*
414.652 365.046 m
424.176 365.046 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.012 707.754 cm
BT
/F0 1 Tf
-0.01 Tc
1 TL
0 0 Td
(patients)Tj
3.6343 0 Td
(aged)Tj
2.393 0 Td
(45)Tj
1.3009 0 Td
(years)Tj
2.6139 0 Td
(or)Tj
1.0861 0 Td
(older,)Tj
2.6556 0 Td
(patients)Tj
3.6343 0 Td
(who)Tj
2.0171 0 Td
(have)Tj
2.3393 0 Td
(had)Tj
1.8499 0 Td
(brucellosis)Tj
4.81 0 Td
(for)Tj
1.3606 0 Td
(a)Tj
0.7639 0 Td
(substantial)Tj
4.8755 0 Td
(period)Tj
2.9242 0 Td
(of)Tj
-38.2586 -1.474 Td
(time,)Tj
2.3393 0 Td
(and)Tj
1.8499 0 Td
(patients)Tj
3.6343 0 Td
(with)Tj
1.9515 0 Td
(back)Tj
2.2856 0 Td
(pain)Tj
2.0588 0 Td
(or)Tj
1.0861 0 Td
(joint)Tj
1.9992 0 Td
(tenderness.)Tj
5.3231 0 Td
(The)Tj
1.9157 0 Td
(clinical)Tj
3.121 0 Td
(management)Tj
5.9438 0 Td
(of)Tj
1.0324 0 Td
(brucellosis)Tj
-34.5407 -1.474 Td
(should)Tj
3.0912 0 Td
(be)Tj
1.3069 0 Td
(improved)Tj
4.237 0 Td
(to)Tj
1.0384 0 Td
(include)Tj
3.3001 0 Td
(sensitive)Tj
4.0103 0 Td
(diagnostic)Tj
4.607 0 Td
(methods)Tj
3.9745 0 Td
(for)Tj
1.3606 0 Td
(subacute)Tj
4.1893 0 Td
(and)Tj
1.85 0 Td
(chronic)Tj
-32.9653 -1.474 Td
(brucellosis.)Tj
ET
Q
q
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 604.12 cm
BT
/F2 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 587.112 cm
BT
/F7 1 Tf
-0.004 Tc
1 TL
0 0 Td
(Brucellosis,)Tj
4.7565 0 Td
(caused)Tj
2.9196 0 Td
(by)Tj
1.1792 0 Td
(bacteria)Tj
3.3789 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(genus)Tj
2.5455 0 Td
(Brucella,)Tj
3.6964 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.6576 0 Td
(major)Tj
2.6079 0 Td
(zoonosis)Tj
3.6907 0 Td
(worldwide.)Tj
4.6828 0 Td
(Although)Tj
-33.4486 -1.2982 Td
(it)Tj
0.7823 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.126 0 Td
(well)Tj
1.8198 0 Td
(controlled)Tj
4.32 0 Td
(in)Tj
1.0318 0 Td
(most)Tj
2.211 0 Td
(developed)Tj
4.269 0 Td
(countries,)Tj
4.1726 0 Td
(brucellosis)Tj
4.4617 0 Td
(is)Tj
0.8503 0 Td
(still)Tj
1.6385 0 Td
(endemic)Tj
3.651 0 Td
(in)Tj
1.0374 0 Td
(Africa,)Tj
-33.9134 -1.3039 Td
(Asia,)Tj
2.1883 0 Td
(the)Tj
1.474 0 Td
(Middle)Tj
3.1011 0 Td
(East,)Tj
2.1089 0 Td
(the)Tj
1.4684 0 Td
(Mediterranean)Tj
6.1851 0 Td
(and)Tj
1.7292 0 Td
(South)Tj
2.5568 0 Td
(America)Tj
3.6453 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(2)Tj
0 g
(].)Tj
1.2642 0 Td
(Human)Tj
3.3166 0 Td
(brucellosis)Tj
4.4617 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
-35.6029 -1.2983 Td
(major)Tj
2.6078 0 Td
(public)Tj
2.7099 0 Td
(health)Tj
2.6759 0 Td
(problem)Tj
3.6113 0 Td
(that)Tj
1.7802 0 Td
(has)Tj
1.542 0 Td
(re-emerged)Tj
4.8189 0 Td
(in)Tj
1.0374 0 Td
(China)Tj
2.6589 0 Td
(since)Tj
2.245 0 Td
(the)Tj
1.4684 0 Td
(mid-1990s,)Tj
4.6715 0 Td
(with)Tj
2.0012 0 Td
(the)Tj
1.4683 0 Td
(high-)Tj
-35.2967 -1.2983 Td
(est)Tj
1.3039 0 Td
(recorded)Tj
3.7927 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(cases)Tj
2.2223 0 Td
(\(56,989)Tj
3.1635 0 Td
(cases\))Tj
2.5625 0 Td
(in)Tj
1.0374 0 Td
(2015)Tj
2.1203 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
2.5966 0 Td
(This)Tj
1.9842 0 Td
(may)Tj
1.9275 0 Td
(be)Tj
1.1509 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(dynamic)Tj
-32.4905 -1.2982 Td
(growth)Tj
3.0727 0 Td
(of)Tj
1.0148 0 Td
(animal)Tj
2.9707 0 Td
(husbandry)Tj
4.4787 0 Td
(in)Tj
1.0375 0 Td
(China,)Tj
2.8856 0 Td
(which)Tj
2.6476 0 Td
(enhances)Tj
3.9117 0 Td
(the)Tj
1.4684 0 Td
(chance)Tj
2.999 0 Td
(of)Tj
1.0148 0 Td
(human)Tj
3.0784 0 Td
(infection.)Tj
4.0195 0 Td
(More-)Tj
-34.5994 -1.3039 Td
(over,)Tj
2.1996 0 Td
(the)Tj
1.4684 0 Td
(national)Tj
3.5036 0 Td
(infectious)Tj
4.1328 0 Td
(disease)Tj
3.0161 0 Td
(surveillance)Tj
4.9492 0 Td
(system)Tj
2.9367 0 Td
(has)Tj
1.5421 0 Td
(reported)Tj
3.6623 0 Td
(an)Tj
1.2019 0 Td
(increased)Tj
4.0025 0 Td
(rate)Tj
1.7461 0 Td
(of)Tj
-34.3613 -1.2983 Td
(human)Tj
3.0784 0 Td
(brucellosis)Tj
4.4617 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
-6.3439 -1.2983 Td
(The)Tj
1.7858 0 Td
(disease)Tj
3.016 0 Td
(is)Tj
0.8504 0 Td
(spread)Tj
2.8516 0 Td
(to)Tj
1.0262 0 Td
(humans)Tj
3.4412 0 Td
(mainly)Tj
2.9877 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(ingestion)Tj
3.9061 0 Td
(of)Tj
1.0148 0 Td
(infected)Tj
3.4186 0 Td
(meat)Tj
2.194 0 Td
(or)Tj
1.0998 0 Td
(unpasteurized)Tj
-31.4416 -1.3039 Td
(dairy)Tj
2.2733 0 Td
(products,)Tj
3.9798 0 Td
(by)Tj
1.1792 0 Td
(contact)Tj
3.1578 0 Td
(with)Tj
1.9956 0 Td
(infected)Tj
3.4186 0 Td
(animals)Tj
3.3335 0 Td
(or)Tj
1.0941 0 Td
(inhalation)Tj
4.303 0 Td
(of)Tj
1.0148 0 Td
(infectious)Tj
4.1272 0 Td
(aerosolized)Tj
4.7055 0 Td
(parti-)Tj
-34.5824 -1.2983 Td
(cles)Tj
1.6724 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.6044 0 Td
(Brucellosis)Tj
4.5297 0 Td
(usually)Tj
3.0217 0 Td
(leads)Tj
2.211 0 Td
(to)Tj
1.0262 0 Td
(protean)Tj
3.3165 0 Td
(manifestation)Tj
5.7146 0 Td
(and)Tj
1.7348 0 Td
(may)Tj
1.9275 0 Td
(have)Tj
2.058 0 Td
(polymorphic)Tj
5.3801 0 Td
(features)Tj
-34.1969 -1.2982 Td
(affecting)Tj
3.651 0 Td
(any)Tj
1.661 0 Td
(organ)Tj
2.5399 0 Td
(system.)Tj
3.1634 0 Td
(The)Tj
1.7802 0 Td
(diagnosis)Tj
3.9571 0 Td
(of)Tj
1.0148 0 Td
(brucellosis)Tj
4.4617 0 Td
(is)Tj
0.8447 0 Td
(challenging)Tj
4.8132 0 Td
(because)Tj
3.3222 0 Td
(unusual)Tj
3.3902 0 Td
(presen-)Tj
-34.5994 -1.3039 Td
(tations)Tj
2.931 0 Td
(and)Tj
1.7347 0 Td
(non-specific)Tj
5.1421 0 Td
(symptoms)Tj
4.3596 0 Td
(can)Tj
1.6271 0 Td
(lead)Tj
1.8482 0 Td
(to)Tj
1.0261 0 Td
(misdiagnosis)Tj
5.4085 0 Td
(and)Tj
1.7291 0 Td
(treatment)Tj
4.1329 0 Td
(delay.)Tj
2.5341 0 Td
(Although)Tj
-32.4734 -1.2983 Td
(the)Tj
1.4683 0 Td
(mortality)Tj
3.9174 0 Td
(rate)Tj
1.7462 0 Td
(is)Tj
0.8504 0 Td
(low,)Tj
1.8822 0 Td
(brucellosis)Tj
4.4617 0 Td
(can)Tj
1.6214 0 Td
(be)Tj
1.1508 0 Td
(severely)Tj
3.3789 0 Td
(debilitating)Tj
4.7735 0 Td
(and)Tj
1.7291 0 Td
(disabling)Tj
3.8438 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(9)Tj
0 g
(].)Tj
1.2642 0 Td
(A)Tj
0.9014 0 Td
(timely)Tj
-34.2479 -1.2983 Td
(and)Tj
1.7291 0 Td
(accurate)Tj
3.5546 0 Td
(diagnosis)Tj
3.9571 0 Td
(is)Tj
0.8504 0 Td
(key)Tj
1.5931 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(clinical)Tj
3.0784 0 Td
(management)Tj
5.4368 0 Td
(of)Tj
1.0148 0 Td
(brucellosis.)Tj
4.6828 0 Td
(There)Tj
2.5795 0 Td
(is)Tj
0.8504 0 Td
(an)Tj
1.2019 0 Td
(urgent)Tj
-33.0234 -1.3039 Td
(need)Tj
2.1429 0 Td
(for)Tj
1.3833 0 Td
(an)Tj
1.2019 0 Td
(increased)Tj
4.0025 0 Td
(awareness)Tj
4.2633 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(clinical)Tj
3.0728 0 Td
(characteristics)Tj
5.9073 0 Td
(of)Tj
1.0148 0 Td
(brucellosis)Tj
4.4617 0 Td
(among)Tj
2.9934 0 Td
(physicians.)Tj
-31.7308 -1.2982 Td
(Between)Tj
3.6056 0 Td
(2000)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(2012,)Tj
2.3471 0 Td
(research)Tj
3.5603 0 Td
(into)Tj
1.8368 0 Td
(the)Tj
1.474 0 Td
(clinical)Tj
3.0728 0 Td
(characteristics)Tj
5.9073 0 Td
(of)Tj
1.0148 0 Td
(brucellosis)Tj
4.4617 0 Td
(was)Tj
1.6952 0 Td
(done)Tj
2.228 0 Td
(in)Tj
-36.2492 -1.2983 Td
(Turkey)Tj
3.101 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(],)Tj
2.0806 0 Td
(Iran)Tj
1.9106 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(],)Tj
2.0806 0 Td
(Greece)Tj
2.999 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(])Tj
1.8539 0 Td
(and)Tj
1.7291 0 Td
(Saudi)Tj
2.4491 0 Td
(Arabia)Tj
2.9197 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(].)Tj
2.0749 0 Td
(But)Tj
1.6271 0 Td
(the)Tj
1.4684 0 Td
(results)Tj
2.8119 0 Td
(differed)Tj
3.3335 0 Td
(between)Tj
-32.4394 -1.2983 Td
(studies.)Tj
3.2087 0 Td
(This)Tj
1.99 0 Td
(may)Tj
1.9275 0 Td
(be)Tj
1.1509 0 Td
(due)Tj
1.7007 0 Td
(to)Tj
1.0205 0 Td
(small)Tj
2.3301 0 Td
(sample)Tj
3.0217 0 Td
(sizes)Tj
2.0466 0 Td
(or)Tj
1.0942 0 Td
(different)Tj
3.6566 0 Td
(methods)Tj
3.685 0 Td
(for)Tj
1.389 0 Td
(case)Tj
1.8595 0 Td
(classification.)Tj
5.5729 0 Td
(In)Tj
-35.6539 -1.3039 Td
(order)Tj
2.4207 0 Td
(to)Tj
1.0262 0 Td
(reliably)Tj
3.1691 0 Td
(examine)Tj
3.5999 0 Td
(the)Tj
1.4684 0 Td
(clinical)Tj
3.0784 0 Td
(characteristics)Tj
5.9017 0 Td
(of)Tj
1.0148 0 Td
(brucellosis,)Tj
4.6885 0 Td
(the)Tj
1.4683 0 Td
(series)Tj
2.4321 0 Td
(used)Tj
2.0579 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(pres-)Tj
-34.8319 -1.2983 Td
(ent)Tj
1.491 0 Td
(study)Tj
2.3867 0 Td
(is)Tj
0.8504 0 Td
(larger)Tj
2.5285 0 Td
(than)Tj
2.0296 0 Td
(that)Tj
1.7801 0 Td
(used)Tj
2.058 0 Td
(in)Tj
1.0375 0 Td
(previous)Tj
3.651 0 Td
(studies,)Tj
3.2087 0 Td
(and)Tj
1.7292 0 Td
(a)Tj
0.6576 0 Td
(common)Tj
3.8438 0 Td
(case)Tj
1.8595 0 Td
(classification)Tj
5.3461 0 Td
(is)Tj
0.8504 0 Td
(used.)Tj
-34.1119 -1.2982 Td
(Reliable)Tj
3.3902 0 Td
(data)Tj
1.9162 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(clinical)Tj
3.0784 0 Td
(characteristics)Tj
5.9017 0 Td
(of)Tj
1.0148 0 Td
(human)Tj
3.0784 0 Td
(brucellosis)Tj
4.4617 0 Td
(should)Tj
2.9197 0 Td
(improve)Tj
3.5773 0 Td
(the)Tj
1.4683 0 Td
(identi-)Tj
-34.7468 -1.3039 Td
(fication)Tj
3.2484 0 Td
(of)Tj
1.0148 0 Td
(relevant)Tj
3.4186 0 Td
(prognostic)Tj
4.49 0 Td
(factors)Tj
2.897 0 Td
(and)Tj
1.7292 0 Td
(improve)Tj
3.5829 0 Td
(the)Tj
1.4684 0 Td
(clinical)Tj
3.0727 0 Td
(management)Tj
5.4368 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6724 0 Td
(debilitating)Tj
-33.046 -1.2983 Td
(condition.)Tj
4.3369 0 Td
(This)Tj
1.9899 0 Td
(study)Tj
2.3868 0 Td
(aims)Tj
2.1033 0 Td
(to)Tj
1.0261 0 Td
(describe)Tj
3.5263 0 Td
(the)Tj
1.4683 0 Td
(symptoms,)Tj
4.5808 0 Td
(signs)Tj
2.2223 0 Td
(and)Tj
1.7348 0 Td
(laboratory)Tj
4.3484 0 Td
(findings)Tj
3.4922 0 Td
(of)Tj
1.0148 0 Td
(2041)Tj
-34.2309 -1.2983 Td
(hospitalized)Tj
5.0059 0 Td
(patients)Tj
3.3732 0 Td
(with)Tj
1.9956 0 Td
(laboratory)Tj
4.3483 0 Td
(confirmed)Tj
4.3993 0 Td
(brucellosis,)Tj
4.6829 0 Td
(and)Tj
1.7347 0 Td
(assess)Tj
2.5172 0 Td
(the)Tj
1.474 0 Td
(risk)Tj
1.7121 0 Td
(factors)Tj
2.9027 0 Td
(for)Tj
1.3889 0 Td
(their)Tj
-35.5348 -1.3039 Td
(clinical)Tj
3.0727 0 Td
(outcomes.)Tj
ET
Q
q
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 222.009 cm
BT
/F2 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Methods)Tj
/F12 1 Tf
0 -1.5023 Td
(Setting)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 186.973 cm
BT
/F7 1 Tf
-0.015 Tc
1 TL
0 0 Td
(The)Tj
1.7461 0 Td
(Sixth)Tj
2.1997 0 Td
(People's)Tj
3.3845 0 Td
(Hospital)Tj
3.5319 0 Td
(of)Tj
0.9922 0 Td
(the)Tj
1.4343 0 Td
(Xinjiang)Tj
3.5773 0 Td
(Uygur)Tj
2.7156 0 Td
(Autonomous)Tj
5.4028 0 Td
(Region)Tj
2.982 0 Td
(\(hereafter)Tj
4.0138 0 Td
(called)Tj
2.4548 0 Td
(the)Tj
-34.435 -1.2982 Td
(Sixth)Tj
2.1996 0 Td
(People's)Tj
3.3846 0 Td
(Hospital\))Tj
3.8551 0 Td
(is)Tj
0.8277 0 Td
(a)Tj
0.6406 0 Td
(tertiary)Tj
3.0557 0 Td
(infectious)Tj
4.0195 0 Td
(disease)Tj
2.9424 0 Td
(specialist)Tj
3.7077 0 Td
(hospital)Tj
3.2881 0 Td
(with)Tj
1.9559 0 Td
(11)Tj
1.1509 0 Td
(clinical)Tj
2.9877 0 Td
(depart-)Tj
-34.0155 -1.2983 Td
(ments)Tj
2.6135 0 Td
(and)Tj
1.7008 0 Td
(460)Tj
1.61 0 Td
(beds.)Tj
2.211 0 Td
(As)Tj
1.2416 0 Td
(an)Tj
1.1849 0 Td
(important)Tj
4.1782 0 Td
(referral)Tj
3.0614 0 Td
(center,)Tj
2.8573 0 Td
(the)Tj
1.44 0 Td
(hospital)Tj
3.2882 0 Td
(approximately)Tj
5.8336 0 Td
(reported)Tj
3.5717 0 Td
(27%)Tj
1.8935 0 Td
(of)Tj
-36.6857 -1.2982 Td
(total)Tj
1.9502 0 Td
(reported)Tj
3.5716 0 Td
(brucellosis)Tj
4.337 0 Td
(cases)Tj
2.1713 0 Td
(in)Tj
1.0091 0 Td
(Xinjiang)Tj
3.5717 0 Td
(yearly.)Tj
2.7552 0 Td
(A)Tj
0.8958 0 Td
(total)Tj
1.9445 0 Td
(of)Tj
0.9921 0 Td
(2041)Tj
2.0807 0 Td
(patients)Tj
3.2825 0 Td
(with)Tj
1.9502 0 Td
(laboratory-con-)Tj
-30.5119 -1.304 Td
(firmed)Tj
2.8516 0 Td
(brucellosis)Tj
4.337 0 Td
(were)Tj
2.0806 0 Td
(admitted)Tj
3.7304 0 Td
(to)Tj
1.0034 0 Td
(the)Tj
1.4343 0 Td
(hospital)Tj
3.2882 0 Td
(between)Tj
3.4526 0 Td
(January)Tj
3.2428 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0.0001 w
7.4999 0 0 6.6659 458.872 139.464 cm
BT
/F7 1 Tf
-0.02 Tc
1 TL
0 0 Td
(st)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 465.789 134.986 cm
BT
/F7 1 Tf
-0.015 Tc
1 TL
0 0 Td
(and)Tj
1.6951 0 Td
(December)Tj
4.2632 0 Td
(31)Tj
ET
Q
q
1 j
1 J
0.0001 w
7.4999 0 0 6.6659 534.671 139.464 cm
BT
/F7 1 Tf
-0.02 Tc
1 TL
0 0 Td
(st)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 541.587 134.986 cm
BT
/F7 1 Tf
-0.015 Tc
1 TL
0 0 Td
(of)Tj
0.9921 0 Td
(2014)Tj
-35.1493 -1.2982 Td
(and)Tj
1.6951 0 Td
(were)Tj
2.0806 0 Td
(included)Tj
3.6227 0 Td
(in)Tj
1.0148 0 Td
(this)Tj
1.627 0 Td
(retrospective)Tj
5.2214 0 Td
(study.)Tj
2.5455 0 Td
(We)Tj
1.5874 0 Td
(accessed)Tj
3.5093 0 Td
(patient)Tj
2.931 0 Td
(medical)Tj
3.2882 0 Td
(records)Tj
3.1237 0 Td
(from)Tj
2.1656 0 Td
(March)Tj
-34.4123 -1.2983 Td
(12)Tj
ET
Q
q
1 j
1 J
0.0001 w
7.4999 0 0 6.6659 209.31 113.442 cm
BT
/F7 1 Tf
-0.02 Tc
1 TL
0 0 Td
(th)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 217.474 109.02 cm
BT
/F7 1 Tf
-0.015 Tc
1 TL
0 0 Td
(to)Tj
1.0034 0 Td
(early)Tj
2.092 0 Td
(April)Tj
2.2507 0 Td
(2016)Tj
2.0806 0 Td
(and)Tj
1.6951 0 Td
(performed)Tj
4.371 0 Td
(telephone)Tj
4.0365 0 Td
(interviews)Tj
4.2066 0 Td
(in)Tj
1.0148 0 Td
(late)Tj
1.5817 0 Td
(April)Tj
2.2507 0 Td
(2016.)Tj
2.2904 0 Td
(The)Tj
1.7518 0 Td
(patient)Tj
2.931 0 Td
(files)Tj
-35.3024 -1.3039 Td
(were)Tj
2.0749 0 Td
(examined)Tj
4.0421 0 Td
(using)Tj
2.3358 0 Td
(a)Tj
0.6406 0 Td
(standardized)Tj
5.2271 0 Td
(form,)Tj
2.3754 0 Td
(which)Tj
2.5908 0 Td
(recorded)Tj
3.7077 0 Td
(demographic)Tj
5.3858 0 Td
(data,)Tj
2.0863 0 Td
(medical)Tj
3.2825 0 Td
(history,)Tj
-33.749 -1.2982 Td
(clinical)Tj
2.9876 0 Td
(and)Tj
1.6951 0 Td
(laboratory)Tj
4.2406 0 Td
(findings,)Tj
3.6227 0 Td
(any)Tj
1.6214 0 Td
(antibiotic)Tj
3.9288 0 Td
(treatment,)Tj
4.2519 0 Td
(and)Tj
1.6951 0 Td
(any)Tj
1.6271 0 Td
(focal)Tj
2.0636 0 Td
(involvements.)Tj
ET
Q
q
1 j
1 J
0.0001 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.26 107.15 23.6976 re
W* n
q
107.15 0 0 23.6976 36 741.26 cm
q
/I1 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0.0001 w
7.9999 0 0 7.9999 473.499 745.795 cm
BT
/F0 1 Tf
-0.005 Tc
1 TL
0 0 Td
(Clinical)Tj
3.3661 0 Td
(features)Tj
3.7701 0 Td
(of)Tj
1.0418 0 Td
(brucellosis)Tj
ET
Q
q
1 j
1 J
0.0001 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.883 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
-0.005 Tc
1 TL
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02055)Tj
4.089 0 Td
(00)Tj
0 g
2.0906 0 Td
(November)Tj
4.7622 0 Td
(26,)Tj
1.5875 0 Td
(2018)Tj
32.5561 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(15)Tj
/F10 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(National)Tj
3.2386 0 Td
(Institutes)Tj
3.6425 0 Td
(of)Tj
0.9496 0 Td
(Health)Tj
2.5725 0 Td
(\(Comprehens)Tj
5.0528 0 Td
(ive)Tj
-15.456 -1.3748 Td
(Internationa)Tj
4.422 0 Td
(l)Tj
0.4181 0 Td
(Program)Tj
3.4796 0 Td
(for)Tj
1.2543 0 Td
(Research)Tj
3.6993 0 Td
(on)Tj
1.1622 0 Td
(AIDS)Tj
2.1189 0 Td
(grant)Tj
-16.5544 -1.3749 Td
(U19)Tj
1.7574 0 Td
(AI51915\))Tj
3.6709 0 Td
(and)Tj
1.5875 0 Td
(Shanghai)Tj
3.6779 0 Td
(Academic)Tj
3.6284 0 Td
(/Technology)Tj
-14.3221 -1.3748 Td
(Research)Tj
3.6992 0 Td
(Leader)Tj
2.7354 0 Td
(\(No.)Tj
1.8142 0 Td
(18XD14003)Tj
4.4221 0 Td
(00\).)Tj
1.7008 0 Td
(H.Y.)Tj
1.7788 0 Td
(has)Tj
-16.1505 -1.3748 Td
(received)Tj
3.3023 0 Td
(investigator)Tj
4.3087 0 Td
(-initiated)Tj
3.4087 0 Td
(research)Tj
3.4158 0 Td
(funding)Tj
-14.4355 -1.3748 Td
(from)Tj
2.0126 0 Td
(Sanofi)Tj
2.5583 0 Td
(Pasteur,)Tj
3.274 0 Td
(GlaxoSmi)Tj
3.5646 0 Td
(thKline,)Tj
2.9835 0 Td
(bioMe)Tj
0 Tc
1.9488 0.0284 Td
()Tj
-0.025 Tc
0.3614 -0.0284 Td
(rieux)Tj
-16.7032 -1.3748 Td
(Diagnostic)Tj
4.1315 0 Td
(Product)Tj
3.1535 0 Td
(\(Shangha)Tj
3.5646 0 Td
(i\),)Tj
0.9497 0 Td
(and)Tj
1.5874 0 Td
(Yichang)Tj
3.2031 0 Td
(HEC)Tj
-16.5898 -1.3748 Td
(Changjiang)Tj
4.3441 0 Td
(Pharmace)Tj
3.7417 0 Td
(utical)Tj
2.1756 0 Td
(Company.)Tj
3.9898 0 Td
(S.L.)Tj
1.6654 0 Td
(is)Tj
-15.9166 -1.3748 Td
(supported)Tj
3.9897 0 Td
(by)Tj
1.1197 0 Td
(the)Tj
1.3678 0 Td
(grants)Tj
2.5724 0 Td
(from)Tj
2.0126 0 Td
(the)Tj
1.3678 0 Td
(National)Tj
3.2386 0 Td
(Natural)Tj
-15.6686 -1.3748 Td
(Science)Tj
3.0968 0 Td
(Fund)Tj
2.0622 0 Td
(\(No.)Tj
1.8142 0 Td
(8177349)Tj
3.3095 0 Td
(8\))Tj
1.0063 0 Td
(and)Tj
1.5874 0 Td
(the)Tj
1.3678 0 Td
(Ministry)Tj
3.2386 0 Td
(of)Tj
-17.4828 -1.3749 Td
(Science)Tj
3.0968 0 Td
(and)Tj
1.5874 0 Td
(Technology)Tj
4.5213 0 Td
(of)Tj
0.9496 0 Td
(China)Tj
-10.1551 -1.3748 Td
(\(2016ZX1)Tj
3.6708 0 Td
(0004222-009\))Tj
5.3505 0 Td
(.)Tj
0.4464 0 Td
(The)Tj
1.5875 0 Td
(funders)Tj
3.0472 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1623 0 Td
(role)Tj
-16.8521 -1.3748 Td
(in)Tj
0.8858 0 Td
(the)Tj
1.3677 0 Td
(study)Tj
2.2677 0 Td
(design,)Tj
2.8985 0 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.7418 0 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
-14.5418 -1.3748 Td
(decision)Tj
3.2882 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
0.9992 0 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-13.7764 -1.3748 Td
(manuscript.)Tj
4.6417 0 Td
(The)Tj
1.5874 0 Td
(views)Tj
2.3174 0 Td
(and)Tj
1.5874 0 Td
(opinions)Tj
3.3945 0 Td
(expressed)Tj
4.004 0 Td
(in)Tj
-17.5324 -1.3748 Td
(this)Tj
1.5661 0 Td
(publica)Tj
2.6433 0 Td
(tion)Tj
1.6158 0 Td
(are)Tj
1.3748 0 Td
(those)Tj
2.2607 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3748 0 Td
(authors)Tj
3.0402 0 Td
(and)Tj
1.5874 0 Td
(are)Tj
-16.4127 -1.3748 Td
(not)Tj
1.4244 0 Td
(necessa)Tj
2.9976 0 Td
(rily)Tj
1.3394 0 Td
(endorsed)Tj
3.6851 0 Td
(by)Tj
1.1126 0 Td
(the)Tj
1.3677 0 Td
(funding)Tj
3.0402 0 Td
(agencie)Tj
2.8205 0 Td
(s.)Tj
/F9 1 Tf
-17.7875 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(read)Tj
1.8426 0 Td
(the)Tj
-16.6253 -1.3749 Td
(journal's)Tj
3.3661 0 Td
(policy)Tj
2.4024 0 Td
(and)Tj
1.5874 0 Td
(have)Tj
1.9559 0 Td
(the)Tj
1.3678 0 Td
(following)Tj
3.5929 0 Td
(conflicts)Tj
3.104 0 Td
(:)Tj
0.4464 0 Td
(H.)Tj
-17.8229 -1.3748 Td
(Y.)Tj
0.9708 0 Td
(has)Tj
1.5378 0 Td
(received)Tj
3.2953 0 Td
(investigator-i)Tj
4.8119 0 Td
(nitiated)Tj
2.9055 0 Td
(research)Tj
-13.5213 -1.3748 Td
(funding)Tj
3.033 0 Td
(from)Tj
2.0127 0 Td
(Sanofi)Tj
2.5582 0 Td
(Pasteur,)Tj
3.2741 0 Td
(GlaxoSmith)Tj
4.2945 0 Td
(Kline,)Tj
-15.1725 -1.3748 Td
(bioMe)Tj
0 Tc
1.9488 0.0283 Td
()Tj
-0.025 Tc
0.3685 -0.0283 Td
(rieux)Tj
2.0339 0 Td
(Diagnostic)Tj
4.1315 0 Td
(Product)Tj
3.1536 0 Td
(\(Shanghai\))Tj
4.0677 0 Td
(,)Tj
0.4465 0 Td
(and)Tj
-16.1505 -1.3748 Td
(Yichang)Tj
3.2031 0 Td
(HEC)Tj
1.8071 0 Td
(Changjian)Tj
3.6426 0 Td
(g)Tj
0.6945 0 Td
(Pharmaceutic)Tj
5.0882 0 Td
(al)Tj
-14.4355 -1.3748 Td
(Company.)Tj
3.9897 0 Td
(This)Tj
1.7788 0 Td
(does)Tj
2.0126 0 Td
(not)Tj
1.4173 0 Td
(alter)Tj
1.8213 0 Td
(our)Tj
1.474 0 Td
(adherenc)Tj
3.4087 0 Td
(e)Tj
0.6449 0 Td
(to)Tj
-16.5473 -1.3819 Td
(PLOS)Tj
2.3315 0 Td
(ONE)Tj
1.8708 0 Td
(policies)Tj
3.0119 0 Td
(on)Tj
1.1622 0 Td
(sharing)Tj
2.9835 0 Td
(data)Tj
1.7929 0 Td
(and)Tj
1.5874 0 Td
(materials.)Tj
ET
Q
endstream
endobj
30 0 obj
<>
endobj
31 0 obj
<>/XObject<>>>
endobj
32 0 obj
[37 0 R 38 0 R]
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0205500.ref014)>>
endobj
38 0 obj
<>/Border[0 0 0]/A 39 0 R>>
endobj
39 0 obj
<>
endobj
33 0 obj
<>stream
q
0.83 0.64 0.02 0 k
551.225 555.307 m
560.75 555.307 l
h
f*
0 g
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 706.053 cm
BT
/F12 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Case)Tj
2.1732 0 Td
(definition)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 689.102 cm
BT
/F7 1 Tf
-0.004 Tc
1 TL
0 0 Td
(A)Tj
0.9014 0 Td
(confirmed)Tj
4.3993 0 Td
(case)Tj
1.8595 0 Td
(of)Tj
1.0148 0 Td
(brucellosis)Tj
4.4617 0 Td
(was)Tj
1.7008 0 Td
(defined)Tj
3.2258 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(patient)Tj
3.0103 0 Td
(with)Tj
1.9956 0 Td
(compatible)Tj
4.6601 0 Td
(clinical)Tj
3.0785 0 Td
(symptoms)Tj
-31.9746 -1.3039 Td
(\(such)Tj
2.398 0 Td
(as)Tj
1.0148 0 Td
(arthralgia,)Tj
4.2973 0 Td
(fever,)Tj
2.4038 0 Td
(sweating,)Tj
3.9288 0 Td
(chills,)Tj
2.5171 0 Td
(headache,)Tj
4.1669 0 Td
(myalgia,)Tj
3.566 0 Td
(malaise\))Tj
3.5433 0 Td
(and)Tj
1.7291 0 Td
(laboratory)Tj
4.354 0 Td
(evidence)Tj
-33.9191 -1.2982 Td
(of)Tj
1.0147 0 Td
(Brucella)Tj
3.4696 0 Td
(infection)Tj
3.7928 0 Td
(diagnosed)Tj
4.2803 0 Td
(by)Tj
1.1848 0 Td
(bacteria)Tj
3.3789 0 Td
(culture)Tj
3.0387 0 Td
(or)Tj
1.0942 0 Td
(SAT)Tj
1.9956 0 Td
(\()Tj
/F6 1 Tf
0 Tc
()Tj
/F7 1 Tf
-0.004 Tc
(1:200\).)Tj
4.0195 0 Td
(Based)Tj
2.5511 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4684 0 Td
(duration)Tj
3.702 0 Td
(of)Tj
-36.2662 -1.2983 Td
(the)Tj
1.4683 0 Td
(systemic)Tj
3.6283 0 Td
(disease)Tj
3.0161 0 Td
(before)Tj
2.7439 0 Td
(admission)Tj
4.3086 0 Td
(to)Tj
1.0261 0 Td
(hospital,)Tj
3.6057 0 Td
(patients)Tj
3.3675 0 Td
(were)Tj
2.1203 0 Td
(divided)Tj
3.2202 0 Td
(into)Tj
1.8368 0 Td
(three)Tj
2.2677 0 Td
(groups:)Tj
-32.6095 -1.3039 Td
(acute)Tj
2.3243 0 Td
(brucellosis)Tj
4.4617 0 Td
(\()Tj
/F13 1 Tf
0 Tc
(<)Tj
/F7 1 Tf
-0.004 Tc
(2)Tj
1.8085 0 Td
(months\),)Tj
3.8495 0 Td
(subacute)Tj
3.719 0 Td
(brucellosis)Tj
4.4617 0 Td
(\(212)Tj
2.5058 0 Td
(months\),)Tj
3.8494 0 Td
(and)Tj
1.7292 0 Td
(chronic)Tj
3.2881 0 Td
(brucellosis)Tj
-31.9972 -1.2983 Td
(\()Tj
/F13 1 Tf
0 Tc
(>)Tj
/F7 1 Tf
-0.004 Tc
(12)Tj
2.279 0 Td
(months\).)Tj
3.8494 0 Td
(All)Tj
1.3947 0 Td
(cases)Tj
2.228 0 Td
(underwent)Tj
4.5694 0 Td
(routine)Tj
3.1634 0 Td
(laboratory)Tj
4.354 0 Td
(tests.)Tj
ET
Q
q
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 586.375 cm
BT
/F12 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Treatment)Tj
4.6724 0 Td
(and)Tj
1.7953 0 Td
(follow-up)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 569.367 cm
BT
/F7 1 Tf
-0.004 Tc
1 TL
0 0 Td
(Patients)Tj
3.4072 0 Td
(were)Tj
2.1259 0 Td
(treated)Tj
2.9934 0 Td
(with)Tj
2.0013 0 Td
(various)Tj
3.1407 0 Td
(combinations)Tj
5.709 0 Td
(of)Tj
1.0148 0 Td
(antibiotics.)Tj
4.6204 0 Td
(The)Tj
1.7858 0 Td
(antibiotics)Tj
4.3994 0 Td
(regimens)Tj
3.9004 0 Td
(were)Tj
-35.0983 -1.2982 Td
(given)Tj
2.3754 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.474 0 Td
(basis)Tj
2.1486 0 Td
(of)Tj
1.0148 0 Td
(China's)Tj
3.2371 0 Td
(Practice)Tj
3.4186 0 Td
(Guideline)Tj
4.1669 0 Td
(for)Tj
1.389 0 Td
(brucellosis)Tj
4.456 0 Td
(diagnosis)Tj
3.9628 0 Td
(and)Tj
1.7291 0 Td
(treatment)Tj
4.1329 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(]:)Tj
-34.7808 -1.2983 Td
(doxycycline)Tj
4.9605 0 Td
(\(100mg)Tj
3.2712 0 Td
(every)Tj
2.3471 0 Td
(12)Tj
1.1735 0 Td
(h\),)Tj
1.3096 0 Td
(rifampin)Tj
3.7361 0 Td
(\(600)Tj
1.9842 0 Td
(-900mg)Tj
3.2825 0 Td
(every)Tj
2.3527 0 Td
(24)Tj
1.1679 0 Td
(h\),)Tj
1.3153 0 Td
(intramuscular)Tj
5.8506 0 Td
(streptomy-)Tj
-32.7512 -1.3039 Td
(cin)Tj
1.4569 0 Td
(\(15mg/kg)Tj
4.0876 0 Td
(every)Tj
2.3471 0 Td
(24)Tj
1.1735 0 Td
(h\),)Tj
1.3153 0 Td
(levofloxacin)Tj
5.0286 0 Td
(\(200mg)Tj
3.2711 0 Td
(every)Tj
2.3471 0 Td
(12)Tj
1.1736 0 Td
(h\),)Tj
1.3096 0 Td
(ciprofloxacin)Tj
5.4878 0 Td
(\(750mg)Tj
3.2712 0 Td
(every)Tj
2.347 0 Td
(12)Tj
1.1736 0 Td
(h\),)Tj
-35.79 -1.2983 Td
(and)Tj
1.7291 0 Td
(co-trimoxazole)Tj
6.2532 0 Td
(\(960mg)Tj
3.2711 0 Td
(every)Tj
2.3471 0 Td
(12)Tj
1.1735 0 Td
(h\).)Tj
1.3096 0 Td
(For)Tj
1.6271 0 Td
(children)Tj
3.5546 0 Td
(under)Tj
2.6192 0 Td
(8)Tj
0.6973 0 Td
(years)Tj
2.2677 0 Td
(of)Tj
1.0148 0 Td
(age)Tj
1.5421 0 Td
(and)Tj
1.7291 0 Td
(pregnant)Tj
-31.1355 -1.2982 Td
(women,)Tj
3.4242 0 Td
(only)Tj
1.9786 0 Td
(rifampin)Tj
3.736 0 Td
(\(600-900mg)Tj
5.0456 0 Td
(every)Tj
2.3471 0 Td
(24)Tj
1.1735 0 Td
(h\))Tj
1.0885 0 Td
(was)Tj
1.7008 0 Td
(provided.)Tj
4.0365 0 Td
(Given)Tj
2.6306 0 Td
(the)Tj
1.4683 0 Td
(effectiveness)Tj
5.2044 0 Td
(of)Tj
1.0148 0 Td
(previ-)Tj
-34.8489 -1.2983 Td
(ous)Tj
1.6157 0 Td
(treatment)Tj
4.1329 0 Td
(and)Tj
1.7291 0 Td
(patient)Tj
3.0104 0 Td
(compliance)Tj
4.8302 0 Td
(\(Xinjiang's)Tj
4.5751 0 Td
(vast)Tj
1.7688 0 Td
(land)Tj
1.9785 0 Td
(posed)Tj
2.5512 0 Td
(a)Tj
0.6576 0 Td
(challenge)Tj
3.9572 0 Td
(to)Tj
1.0261 0 Td
(subsequent)Tj
-31.8328 -1.3039 Td
(patient)Tj
3.0047 0 Td
(visits\),)Tj
2.7949 0 Td
(the)Tj
1.4683 0 Td
(treatment)Tj
4.1386 0 Td
(duration)Tj
3.702 0 Td
(was)Tj
1.7008 0 Td
(extended)Tj
3.8551 0 Td
(to)Tj
1.0261 0 Td
(36)Tj
1.6895 0 Td
(months)Tj
3.2825 0 Td
(for)Tj
1.3833 0 Td
(all)Tj
1.1451 0 Td
(patients.)Tj
3.5944 0 Td
(The)Tj
1.7858 0 Td
(out-)Tj
-34.5711 -1.2983 Td
(come)Tj
2.3867 0 Td
(of)Tj
1.0035 0 Td
(treatment)Tj
4.1272 0 Td
(\(including)Tj
4.3766 0 Td
(medication)Tj
4.7282 0 Td
(compliance)Tj
4.8189 0 Td
(and)Tj
1.7234 0 Td
(symptom)Tj
3.9912 0 Td
(recovery\))Tj
3.9798 0 Td
(was)Tj
1.6894 0 Td
(investigated)Tj
-32.8249 -1.2982 Td
(by)Tj
1.1792 0 Td
(telephone)Tj
4.1385 0 Td
(interview.)Tj
4.1839 0 Td
(Admittedly)Tj
4.7679 0 Td
(telephone)Tj
4.1329 0 Td
(interview)Tj
3.9571 0 Td
(is)Tj
0.8504 0 Td
(not)Tj
1.576 0 Td
(the)Tj
1.4684 0 Td
(ideal)Tj
2.1146 0 Td
(method)Tj
3.3279 0 Td
(of)Tj
1.0148 0 Td
(follow-up,)Tj
-32.7116 -1.304 Td
(but)Tj
1.5533 0 Td
(since)Tj
2.2394 0 Td
(in)Tj
1.0375 0 Td
(chronic/)Tj
3.6169 0 Td
(persisting)Tj
4.1046 0 Td
(brucellosis)Tj
4.4617 0 Td
(the)Tj
1.4683 0 Td
(symptoms)Tj
4.3597 0 Td
(are)Tj
1.4456 0 Td
(often)Tj
2.2848 0 Td
(subjective)Tj
4.1669 0 Td
(and)Tj
1.7291 0 Td
(telephone)Tj
-32.4678 -1.2982 Td
(interview)Tj
3.9571 0 Td
(allowed)Tj
3.2882 0 Td
(for)Tj
1.3889 0 Td
(a)Tj
0.652 0 Td
(larger)Tj
2.5285 0 Td
(enrollment)Tj
4.6544 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3676 0 Td
(in)Tj
1.0374 0 Td
(follow-up,)Tj
4.32 0 Td
(we)Tj
1.3266 0 Td
(considered)Tj
4.6035 0 Td
(this)Tj
1.6724 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(an)Tj
-35.9884 -1.2983 Td
(acceptable)Tj
4.3483 0 Td
(follow-up)Tj
4.0932 0 Td
(method.)Tj
ET
Q
q
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 375.704 cm
BT
/F12 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Data)Tj
2.2441 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 358.696 cm
BT
/F7 1 Tf
-0.004 Tc
1 TL
0 0 Td
(Data)Tj
2.1203 0 Td
(were)Tj
2.1259 0 Td
(entered)Tj
3.2315 0 Td
(into)Tj
1.8425 0 Td
(Epidata)Tj
3.2712 0 Td
(\(version)Tj
3.4922 0 Td
(2.0,)Tj
1.6214 0 Td
(Odense,)Tj
3.4753 0 Td
(Denmark\).)Tj
4.6148 0 Td
(Medians)Tj
3.6736 0 Td
(and)Tj
1.7292 0 Td
(interquartile)Tj
-31.1979 -1.2982 Td
(ranges)Tj
2.8232 0 Td
(\(IQRs\))Tj
2.9707 0 Td
(were)Tj
2.1203 0 Td
(calculated)Tj
4.2066 0 Td
(for)Tj
1.3833 0 Td
(continuous)Tj
4.7395 0 Td
(variables,)Tj
3.9401 0 Td
(and)Tj
1.7292 0 Td
(compared)Tj
4.2462 0 Td
(between)Tj
3.5263 0 Td
(different)Tj
-31.6854 -1.3039 Td
(groups)Tj
2.9706 0 Td
(using)Tj
2.3868 0 Td
(the)Tj
1.4683 0 Td
(Wilcoxon)Tj
4.1499 0 Td
(rank)Tj
2.075 0 Td
(sum)Tj
1.9275 0 Td
(test.)Tj
1.8255 0 Td
(For)Tj
1.6271 0 Td
(categorical)Tj
4.5127 0 Td
(variables,)Tj
3.9402 0 Td
(case)Tj
1.8651 0 Td
(frequencies)Tj
4.7849 0 Td
(in)Tj
1.0318 0 Td
(each)Tj
-34.5654 -1.2983 Td
(category)Tj
3.5943 0 Td
(were)Tj
2.1259 0 Td
(compared)Tj
4.2406 0 Td
(using)Tj
2.3925 0 Td
(a)Tj
0.6519 0 Td
(Chi-square)Tj
4.6545 0 Td
(test)Tj
1.5987 0 Td
(or)Tj
1.0998 0 Td
(Fisher's)Tj
3.2769 0 Td
(exact)Tj
2.262 0 Td
(test.)Tj
1.8255 0 Td
(For)Tj
1.6271 0 Td
(multiple)Tj
3.5659 0 Td
(compari-)Tj
-32.9156 -1.2983 Td
(sons,)Tj
2.2223 0 Td
(the)Tj
1.4683 0 Td
(Bonferroni)Tj
4.6318 0 Td
(correction)Tj
4.3597 0 Td
(was)Tj
1.7008 0 Td
(applied.)Tj
3.3788 0 Td
(To)Tj
1.338 0 Td
(further)Tj
3.0274 0 Td
(examine)Tj
3.5999 0 Td
(the)Tj
1.474 0 Td
(association)Tj
4.6262 0 Td
(between)Tj
-31.8272 -1.3039 Td
(potential)Tj
3.7587 0 Td
(risk)Tj
1.7178 0 Td
(factors)Tj
2.9026 0 Td
(and)Tj
1.7291 0 Td
(treatment)Tj
4.1329 0 Td
(outcome,)Tj
3.9572 0 Td
(we)Tj
1.3266 0 Td
(first)Tj
1.8028 0 Td
(performed)Tj
4.473 0 Td
(univariate)Tj
4.2463 0 Td
(analysis.)Tj
3.549 0 Td
(For)Tj
1.627 0 Td
(mul-)Tj
-35.223 -1.2982 Td
(tivariable)Tj
3.9231 0 Td
(logistic)Tj
3.0557 0 Td
(regression,)Tj
4.5411 0 Td
(we)Tj
1.3323 0 Td
(included)Tj
3.7076 0 Td
(variables)Tj
3.7191 0 Td
(with)Tj
/F14 1 Tf
2.0012 0 Td
()Tj
/F13 1 Tf
0 Tc
(<)Tj
/F7 1 Tf
-0.004 Tc
(0.05)Tj
3.1238 0 Td
(in)Tj
1.0375 0 Td
(univariate)Tj
4.2462 0 Td
(analysis)Tj
3.3222 0 Td
(or)Tj
1.0999 0 Td
(those)Tj
-35.1097 -1.2983 Td
(believed)Tj
3.4922 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(potential)Tj
3.7587 0 Td
(risk)Tj
1.7178 0 Td
(factors)Tj
2.9027 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(outcome.)Tj
3.9515 0 Td
(The)Tj
1.7858 0 Td
(software)Tj
3.5829 0 Td
(program)Tj
3.7077 0 Td
(SAS)Tj
-34.7978 -1.2983 Td
(9.3)Tj
1.3946 0 Td
(and)Tj
1.7291 0 Td
(R)Tj
0.8447 0 Td
(3.3.1)Tj
2.0977 0 Td
(were)Tj
2.1203 0 Td
(used)Tj
2.0636 0 Td
(to)Tj
1.0204 0 Td
(analyze)Tj
3.1748 0 Td
(the)Tj
1.4684 0 Td
(data.)Tj
ET
Q
q
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 217.02 cm
BT
/F12 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Ethical)Tj
3.1417 0 Td
(Approval)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 200.012 cm
BT
/F7 1 Tf
-0.004 Tc
1 TL
0 0 Td
(Ethical)Tj
2.9876 0 Td
(approval)Tj
3.6964 0 Td
(\(no.)Tj
1.8425 0 Td
(201533\))Tj
3.4129 0 Td
(was)Tj
1.7008 0 Td
(obtained)Tj
3.736 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(Institutional)Tj
5.159 0 Td
(Review)Tj
3.0954 0 Td
(Board)Tj
2.6419 0 Td
(\(IRB\))Tj
2.4435 0 Td
(of)Tj
-34.3897 -1.3039 Td
(China)Tj
2.6588 0 Td
(CDC)Tj
2.2847 0 Td
(before)Tj
2.7383 0 Td
(the)Tj
1.4683 0 Td
(survey)Tj
2.8176 0 Td
(began.)Tj
2.8233 0 Td
(With)Tj
2.2791 0 Td
(IRB's)Tj
2.3357 0 Td
(ratification,)Tj
4.8472 0 Td
(we)Tj
1.3266 0 Td
(signed)Tj
2.8177 0 Td
(a)Tj
0.6519 0 Td
(confidentiality)Tj
6.0208 0 Td
(agree-)Tj
-35.07 -1.2982 Td
(ment)Tj
2.3073 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(hospital)Tj
3.3789 0 Td
(to)Tj
1.0261 0 Td
(use)Tj
1.5307 0 Td
(patient)Tj
3.0047 0 Td
(medical)Tj
3.3619 0 Td
(records)Tj
3.2088 0 Td
(for)Tj
1.3833 0 Td
(research)Tj
3.5546 0 Td
(purposes.)Tj
4.0309 0 Td
(We)Tj
1.61 0 Td
(confirmed)Tj
-31.8668 -1.2983 Td
(that)Tj
1.7744 0 Td
(all)Tj
1.1509 0 Td
(participant)Tj
4.5978 0 Td
(identifying)Tj
4.575 0 Td
(information)Tj
5.074 0 Td
(\(including)Tj
4.3824 0 Td
(patient)Tj
3.0047 0 Td
(names,)Tj
3.033 0 Td
(ID)Tj
1.2983 0 Td
(numbers,)Tj
4.0025 0 Td
(home)Tj
-32.893 -1.2983 Td
(addresses)Tj
4.0081 0 Td
(and)Tj
1.7291 0 Td
(telephone)Tj
4.1386 0 Td
(numbers\))Tj
4.1159 0 Td
(would)Tj
2.7155 0 Td
(not)Tj
1.5761 0 Td
(be)Tj
1.1452 0 Td
(included)Tj
3.7134 0 Td
(in)Tj
1.0374 0 Td
(recordings,)Tj
4.7112 0 Td
(written)Tj
3.1124 0 Td
(descriptions)Tj
-32.0029 -1.3039 Td
(or)Tj
1.0941 0 Td
(publications.)Tj
5.3518 0 Td
(Because)Tj
3.3959 0 Td
(written)Tj
3.1067 0 Td
(informed)Tj
3.9742 0 Td
(consent)Tj
3.3335 0 Td
(is)Tj
0.8447 0 Td
(difficult)Tj
3.3562 0 Td
(to)Tj
1.0262 0 Td
(obtain)Tj
2.7779 0 Td
(during)Tj
2.931 0 Td
(a)Tj
0.652 0 Td
(telephone)Tj
4.1385 0 Td
(sur-)Tj
-35.9827 -1.2982 Td
(vey,)Tj
1.7744 0 Td
(the)Tj
1.474 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(verbal)Tj
2.6589 0 Td
(informed)Tj
3.9685 0 Td
(consent)Tj
3.3335 0 Td
(was)Tj
1.6951 0 Td
(approved)Tj
3.9742 0 Td
(by)Tj
1.1848 0 Td
(the)Tj
1.4684 0 Td
(IRB)Tj
1.7631 0 Td
(for)Tj
1.3833 0 Td
(this)Tj
1.6724 0 Td
(retrospective)Tj
5.3632 0 Td
(study.)Tj
-34.2593 -1.2983 Td
(Verbal)Tj
2.8969 0 Td
(informed)Tj
3.9685 0 Td
(consent)Tj
3.3335 0 Td
(was)Tj
1.7008 0 Td
(obtained)Tj
3.7304 0 Td
(from)Tj
2.2053 0 Td
(all)Tj
1.1452 0 Td
(respondents)Tj
5.108 0 Td
(over)Tj
1.9786 0 Td
(the)Tj
1.4683 0 Td
(phone)Tj
2.7439 0 Td
(and)Tj
1.7292 0 Td
(documented)Tj
-32.0086 -1.3039 Td
(in)Tj
1.0318 0 Td
(forms.)Tj
2.7949 0 Td
(For)Tj
1.6271 0 Td
(subjects)Tj
3.3789 0 Td
(younger)Tj
3.5149 0 Td
(than)Tj
2.0296 0 Td
(17)Tj
1.1735 0 Td
(years)Tj
2.2621 0 Td
(of)Tj
1.0147 0 Td
(age,)Tj
1.7689 0 Td
(we)Tj
1.3266 0 Td
(obtained)Tj
3.736 0 Td
(verbal)Tj
2.6532 0 Td
(consent)Tj
3.3335 0 Td
(from)Tj
2.2054 0 Td
(their)Tj
-33.8511 -1.2983 Td
(parents)Tj
3.1747 0 Td
(or)Tj
1.0942 0 Td
(legal)Tj
2.0353 0 Td
(guardians.)Tj
ET
Q
q
1 j
1 J
0.0001 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.26 107.15 23.6976 re
W* n
q
107.15 0 0 23.6976 36 741.26 cm
q
/I1 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0.0001 w
7.9999 0 0 7.9999 473.499 745.795 cm
BT
/F0 1 Tf
-0.005 Tc
1 TL
0 0 Td
(Clinical)Tj
3.3661 0 Td
(features)Tj
3.7701 0 Td
(of)Tj
1.0418 0 Td
(brucellosis)Tj
ET
Q
q
1 j
1 J
0.0001 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.883 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
-0.005 Tc
1 TL
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.02055)Tj
4.089 0 Td
(00)Tj
0 g
2.0906 0 Td
(November)Tj
4.7622 0 Td
(26,)Tj
1.5875 0 Td
(2018)Tj
32.5561 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(15)Tj
ET
Q
endstream
endobj
40 0 obj
<>
endobj
41 0 obj
<>/XObject<>>>
endobj
44 0 obj
<>stream
xy]Uu ZTYqTR: XfkUjZMBP[jPVED
D)u:Q"CN8U-~wd=w{/9{}k^$ L;kӦMӎK@$hlOG:" H@$ H@WƢV$ H@6ĄNl3K
H@$ H@GTa9+$ L7_% H@$ H`{w/ H@$Hv;o=%1& H@$ H@X8" 2??ivawޙ]vمw1)UN!UV>)>RJ9sX(<ήZnS] x)c6|L9;AߥXz
,wtGҭr
#rÌLmT
N0ꠈLGJ'ةDk۟& Vf|0 w)/aYfÌ<'El#to5I[M8anՐۡ
+w H@$ H@'D˖-}sobX=ƪbI,G~tI@R$WeF9*UNkXBV[=X+CkKZqUS
-ԗf
y{
3O}j`=z(-g\5L_`jrʭ{rMH˱S3lh3[95rQٖkhcܦv8)dT.ʷvm9bhrL9er S5dX=)Xj2L
@Jֹfd?Z[^zdD\!wfXqݤ<=y^^bUV-9< H@$ H@R'@Jvlfw_n߰ -O[}JYX(LÐ{Kl8}쌫qؒ{:OOoKXrRי㓀$ H@$ ,qVNX|E]D¢s%ѩ<ȦMȶYXUΉ2-CkuZ[Vh%\6KuucbZ˥8WCkl3K{zYۧ0W1Buis avZ#4yȏS.%ܺ7WuV(oYFK/51U$ H@$ H`j$;_y;jJ;b\l{a
gG7Bb(tr+Z}D-],@gW؆3
j.@aÅDQma·|+S%q$ H@$ H`$;ݮ`?dHo% H@Xb*1bŊJ_/KlG$ H@$0
C+&H4pp$ ,Z֭ˊN8aƍkg$ H@$ H`iOVLo4Lz H@$0.Z$ H@$ 9vDm9W$ H`Lʕ+Q1*& H@$ H@XTj^Պ.3&c H@4hr݉#f,]$ H@$0+&la$ H@$ m$пbbvy1^T$ H@&P VLNbbHU$ H@$ lGb"[9Uk H@j++WB#UE$ H@$ %YILM::ݖ$ H` XnkŊ'D%p$ H@$ L!,011!K@&@Ӎ7XI_?% H@$ H@h "j_?9Zy$ H` Tb]1r~
v' H@$ H@+m!˗sĆ
hJ\ H@$0 'P_YRE$ H@$ N`~6mw?u@$ %9:/Nsj$ H@$ I'yVLd+'~ҟK@ 61Q+&LL,'$ H@$ H`: ":gL$1tq$ ,ӪUbpO$ H@$ H@*&튉M6W?2$ H@[u5Z1sYk$ H@$ #оsY1}.,H$ DJ H@$ H@'O{̽VLp
ڜJ@$T TbbʕbR}K$ H@<6ï}q?}( H@`+Ӆ{^uR$ H@$ @~7~gM\4% H@h7xc}}ݰ; H@$ H@@Ri_+&i hof[|h=okDuo^EG}1%0m\|TpO}Pb@yl·v&̇qlrye̢)% H@$ H@J )i_+&