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Environmental impact on health across generations: policy meets biology. A review of animal and human models

Environmental impact on health across generations: policy meets biology. A review of animal and human models
Environmental impact on health across generations: policy meets biology. A review of animal and human models
Intrauterine and early life has been accepted as important susceptibility windows for environmental exposure and disease later in life. Emerging evidence suggests that exposure before conception may also influence health in future generations. There has been little research on human data to support this until now. This review gives evidence from epigenetic as well as immunologic research, and from animal as well as human models, supporting the hypothesis that there may be important susceptibility windows before conception in relation to exposure such as obesity, diet, smoking and infections. It is likely that we can identify vulnerability windows in men and women in which interventions may have an impact on several generations in addition to individual health. Establishing vulnerability windows affecting health over future generations, and not only in the now or the near future of the individual, may provide tremendous opportunities for health policy and practice.
2056-6646
Lønnebotn, Marianne
56cef848-7af0-4769-89db-6bca63289e05
El-merhie, Natalia
af5fbcd9-95f4-449c-b7da-dfd9e68fdc3d
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Horsnell, William
b490aa17-3f96-49d3-8b02-821bf14e2537
Krauss-etschmann, Susanne
c7bddda3-701e-468e-8515-fd9722ff8085
Real, Francisco Gómez
4d44c9a4-9d5f-4e14-9aa7-fc054ac006a2
Svanes, Cecilie
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Lønnebotn, Marianne
56cef848-7af0-4769-89db-6bca63289e05
El-merhie, Natalia
af5fbcd9-95f4-449c-b7da-dfd9e68fdc3d
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Horsnell, William
b490aa17-3f96-49d3-8b02-821bf14e2537
Krauss-etschmann, Susanne
c7bddda3-701e-468e-8515-fd9722ff8085
Real, Francisco Gómez
4d44c9a4-9d5f-4e14-9aa7-fc054ac006a2
Svanes, Cecilie
4a547f80-e3d3-47b4-ae0a-2741ad93c629

Lønnebotn, Marianne, El-merhie, Natalia, Holloway, John W., Horsnell, William, Krauss-etschmann, Susanne, Real, Francisco Gómez and Svanes, Cecilie (2018) Environmental impact on health across generations: policy meets biology. A review of animal and human models. Global Challenges, 9 (2). (doi:10.3390/challe9020042).

Record type: Article

Abstract

Intrauterine and early life has been accepted as important susceptibility windows for environmental exposure and disease later in life. Emerging evidence suggests that exposure before conception may also influence health in future generations. There has been little research on human data to support this until now. This review gives evidence from epigenetic as well as immunologic research, and from animal as well as human models, supporting the hypothesis that there may be important susceptibility windows before conception in relation to exposure such as obesity, diet, smoking and infections. It is likely that we can identify vulnerability windows in men and women in which interventions may have an impact on several generations in addition to individual health. Establishing vulnerability windows affecting health over future generations, and not only in the now or the near future of the individual, may provide tremendous opportunities for health policy and practice.

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More information

Accepted/In Press date: 10 December 2018
e-pub ahead of print date: 11 December 2018
Published date: 11 December 2018

Identifiers

Local EPrints ID: 426844
URI: http://eprints.soton.ac.uk/id/eprint/426844
ISSN: 2056-6646
PURE UUID: 1213512c-1185-47a4-b6fb-bf47bf54680a
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

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Date deposited: 13 Dec 2018 17:30
Last modified: 16 Mar 2024 02:57

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Contributors

Author: Marianne Lønnebotn
Author: Natalia El-merhie
Author: William Horsnell
Author: Susanne Krauss-etschmann
Author: Francisco Gómez Real
Author: Cecilie Svanes

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