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Sniffing out causes of gastrointestinal disorders: A review of volatile metabolomic biomarkers

Sniffing out causes of gastrointestinal disorders: A review of volatile metabolomic biomarkers
Sniffing out causes of gastrointestinal disorders: A review of volatile metabolomic biomarkers

Distinct changes can be observed in the odor of human excretions during health and disease. Identifying underlying volatile metabolites responsible for these odorous changes can be correlated with the pathological process within the body. Advances in the technology have enabled us to interpret the volatile signature of these changes in the odor. This has opened a promising area to lay the foundations of a rapid, noninvasive and point of care diagnostic tool. This review explores the diagnostic potential of volatile organic metabolites as novel biomarkers and extends the discussion on the clinical applications of these biomarkers in gastrointestinal disorders.

colorectal cancer, gas chromatography-mass spectrometer, gastrointestinal disorders, inflammatory bowel disease, irritable bowel syndrome, metabolomics, noninvasive biomarkers, volatile organic metabolites
1752-0363
1139-1148
Ahmed, Iftikhar
495c2595-40e4-405c-bb54-cc2367424fde
Niaz, Zafar
2e629faf-f710-4359-b592-21b386867846
Ewbank, Frederick
c5b6e441-c552-4d1a-bfc3-d1c5695e24c7
Akarca, Danyal
d0cdcb85-5e96-4ed6-861c-d28ac0844f80
Felwick, Richard
b19f1ab6-1de4-4df6-b149-4bc337c3fcb9
Furnari, Manuele
2731a4f4-5051-4ff8-8a81-bbdece511720
Ahmed, Iftikhar
495c2595-40e4-405c-bb54-cc2367424fde
Niaz, Zafar
2e629faf-f710-4359-b592-21b386867846
Ewbank, Frederick
c5b6e441-c552-4d1a-bfc3-d1c5695e24c7
Akarca, Danyal
d0cdcb85-5e96-4ed6-861c-d28ac0844f80
Felwick, Richard
b19f1ab6-1de4-4df6-b149-4bc337c3fcb9
Furnari, Manuele
2731a4f4-5051-4ff8-8a81-bbdece511720

Ahmed, Iftikhar, Niaz, Zafar, Ewbank, Frederick, Akarca, Danyal, Felwick, Richard and Furnari, Manuele (2018) Sniffing out causes of gastrointestinal disorders: A review of volatile metabolomic biomarkers. Biomarkers in Medicine, 12 (10), 1139-1148. (doi:10.2217/bmm-2018-0074).

Record type: Review

Abstract

Distinct changes can be observed in the odor of human excretions during health and disease. Identifying underlying volatile metabolites responsible for these odorous changes can be correlated with the pathological process within the body. Advances in the technology have enabled us to interpret the volatile signature of these changes in the odor. This has opened a promising area to lay the foundations of a rapid, noninvasive and point of care diagnostic tool. This review explores the diagnostic potential of volatile organic metabolites as novel biomarkers and extends the discussion on the clinical applications of these biomarkers in gastrointestinal disorders.

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More information

Accepted/In Press date: 30 May 2018
e-pub ahead of print date: 7 September 2018
Published date: 1 October 2018
Keywords: colorectal cancer, gas chromatography-mass spectrometer, gastrointestinal disorders, inflammatory bowel disease, irritable bowel syndrome, metabolomics, noninvasive biomarkers, volatile organic metabolites

Identifiers

Local EPrints ID: 426898
URI: https://eprints.soton.ac.uk/id/eprint/426898
ISSN: 1752-0363
PURE UUID: 9d212d9d-64c9-4ff8-81e6-e29ff300749f

Catalogue record

Date deposited: 14 Dec 2018 17:30
Last modified: 14 Dec 2018 17:30

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