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Hiding in plain sight: Soluble immunomodulatory receptors

Hiding in plain sight: Soluble immunomodulatory receptors
Hiding in plain sight: Soluble immunomodulatory receptors

Alternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated blockbuster antibodies for the treatment of cancer. We propose that the soluble variants of these receptors contribute to immune regulation and offer potential as targets for immunotherapy.

1471-4906
771-774
Dahal, Lekh N.
1e993a7a-b007-4187-82ea-e28dd3920b66
Schwarz, Herbert
46be1106-1b58-437e-ac96-48592910a89a
Ward, Frank J.
ea0f07fa-2f95-4609-81a9-1a6699c874e6
Dahal, Lekh N.
1e993a7a-b007-4187-82ea-e28dd3920b66
Schwarz, Herbert
46be1106-1b58-437e-ac96-48592910a89a
Ward, Frank J.
ea0f07fa-2f95-4609-81a9-1a6699c874e6

Dahal, Lekh N., Schwarz, Herbert and Ward, Frank J. (2018) Hiding in plain sight: Soluble immunomodulatory receptors. Trends in Immunology, 39 (10), 771-774. (doi:10.1016/j.it.2018.08.004).

Record type: Article

Abstract

Alternatively spliced natural soluble isoforms of immunomodulatory receptors [cytotoxic T lymphocyte antigen-4 (CTLA-4), 4-1BB, and programmed death-1 (PD-1)/PD-L1] have been overlooked in favor of their cell-surface-bound counterparts that have generated blockbuster antibodies for the treatment of cancer. We propose that the soluble variants of these receptors contribute to immune regulation and offer potential as targets for immunotherapy.

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More information

Accepted/In Press date: 1 August 2018
e-pub ahead of print date: 5 September 2018
Published date: October 2018

Identifiers

Local EPrints ID: 426918
URI: http://eprints.soton.ac.uk/id/eprint/426918
DOI: doi:10.1016/j.it.2018.08.004
ISSN: 1471-4906
PURE UUID: 53d6ca91-8319-4187-a976-f858428fd809

Catalogue record

Date deposited: 14 Dec 2018 17:30
Last modified: 15 Mar 2024 21:41

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Contributors

Author: Lekh N. Dahal
Author: Herbert Schwarz
Author: Frank J. Ward

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