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Mediterranean diet and knee osteoarthritis outcomes: a longitudinal cohort study

Mediterranean diet and knee osteoarthritis outcomes: a longitudinal cohort study
Mediterranean diet and knee osteoarthritis outcomes: a longitudinal cohort study
Objectives: Mediterranean diet has several beneficial effects on health, but data regarding the association between Mediterranean diet and knee osteoarthritis (OA) are limited mainly to cross-sectional studies. We investigated whether higher Mediterranean diet adherence is prospectively associated with lower risk of radiographic OA (ROA), radiographic symptomatic knee OA (SxOA) and pain worsening in North American people at high risk or having knee OA.

Methods: adherence to the Mediterranean diet was evaluated using a validated Mediterranean diet score (aMED), categorized in five categories (Q1 to Q5, higher values reflecting higher adherence to Mediterranean diet). Knee OA outcomes included incident (1) ROA, (2) SxOA, as the new onset of a combination of a painful knee and ROA, (3) knee pain worsening, i.e. a Western Ontario and McMaster Universities Osteoarthritis Index difference between baseline and each annual exam of ≥14%.

Results: 4330 subjects (mean age: 61.1 years; 58.0% females) were included. Based on a multivariable Poisson regression analysis, during a mean follow-up period of 4 years, participants who were more highly adherent to a Mediterranean diet (Q5) reported lower risk of pain worsening (relative risk, RR = 0.96; 95% CI: 0.91–0.999) compared to those in Q1. In 2994 people free from SxOA at baseline, higher adherence to a Mediterranean diet was associated with a lower risk for SxOA during follow-up by 9% (Q5 vs. Q1; RR = 0.91; 95% CI: 0.82–0.998). No significant associations emerged between aMED and incident ROA.

Conclusion: higher adherence to Mediterranean diet is associated with a lower risk of pain worsening and symptomatic forms of knee OA.
0261-5614
Veronese, Nicola
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Koyanagi, Ai
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Stubbs, Brendon
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Cooper, Cyrus
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Guglielmi, Giuseppe
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Rizzoli, René
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Punzi, Leonardo
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Rogoli, Domenico
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Caruso, Maria Gabriella
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Rotolo, Ornella
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Notarnicola, Maria
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Al-Daghri, Nasser M.
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Smith, Lee
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Reginster, Jean-Yves
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Maggi, Stefania
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Veronese, Nicola
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Koyanagi, Ai
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Stubbs, Brendon
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Cooper, Cyrus
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Guglielmi, Giuseppe
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Rizzoli, René
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Punzi, Leonardo
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Rogoli, Domenico
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Caruso, Maria Gabriella
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Rotolo, Ornella
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Notarnicola, Maria
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Al-Daghri, Nasser M.
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Smith, Lee
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Reginster, Jean-Yves
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Maggi, Stefania
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Veronese, Nicola, Koyanagi, Ai, Stubbs, Brendon, Cooper, Cyrus, Guglielmi, Giuseppe, Rizzoli, René, Punzi, Leonardo, Rogoli, Domenico, Caruso, Maria Gabriella, Rotolo, Ornella, Notarnicola, Maria, Al-Daghri, Nasser M., Smith, Lee, Reginster, Jean-Yves and Maggi, Stefania (2018) Mediterranean diet and knee osteoarthritis outcomes: a longitudinal cohort study. Clinical Nutrition. (doi:10.1016/j.clnu.2018.11.032).

Record type: Article

Abstract

Objectives: Mediterranean diet has several beneficial effects on health, but data regarding the association between Mediterranean diet and knee osteoarthritis (OA) are limited mainly to cross-sectional studies. We investigated whether higher Mediterranean diet adherence is prospectively associated with lower risk of radiographic OA (ROA), radiographic symptomatic knee OA (SxOA) and pain worsening in North American people at high risk or having knee OA.

Methods: adherence to the Mediterranean diet was evaluated using a validated Mediterranean diet score (aMED), categorized in five categories (Q1 to Q5, higher values reflecting higher adherence to Mediterranean diet). Knee OA outcomes included incident (1) ROA, (2) SxOA, as the new onset of a combination of a painful knee and ROA, (3) knee pain worsening, i.e. a Western Ontario and McMaster Universities Osteoarthritis Index difference between baseline and each annual exam of ≥14%.

Results: 4330 subjects (mean age: 61.1 years; 58.0% females) were included. Based on a multivariable Poisson regression analysis, during a mean follow-up period of 4 years, participants who were more highly adherent to a Mediterranean diet (Q5) reported lower risk of pain worsening (relative risk, RR = 0.96; 95% CI: 0.91–0.999) compared to those in Q1. In 2994 people free from SxOA at baseline, higher adherence to a Mediterranean diet was associated with a lower risk for SxOA during follow-up by 9% (Q5 vs. Q1; RR = 0.91; 95% CI: 0.82–0.998). No significant associations emerged between aMED and incident ROA.

Conclusion: higher adherence to Mediterranean diet is associated with a lower risk of pain worsening and symptomatic forms of knee OA.

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Accepted/In Press date: 29 November 2018
e-pub ahead of print date: 4 December 2018

Identifiers

Local EPrints ID: 427032
URI: https://eprints.soton.ac.uk/id/eprint/427032
ISSN: 0261-5614
PURE UUID: 2186a1c9-a566-4e08-adca-bb4f307331af
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 20 Dec 2018 17:30
Last modified: 10 Dec 2019 05:06

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Contributors

Author: Nicola Veronese
Author: Ai Koyanagi
Author: Brendon Stubbs
Author: Cyrus Cooper ORCID iD
Author: Giuseppe Guglielmi
Author: René Rizzoli
Author: Leonardo Punzi
Author: Domenico Rogoli
Author: Maria Gabriella Caruso
Author: Ornella Rotolo
Author: Maria Notarnicola
Author: Nasser M. Al-Daghri
Author: Lee Smith
Author: Jean-Yves Reginster
Author: Stefania Maggi

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