The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Epigenome-wide meta-analysis of DNA methylation and childhood asthma

Epigenome-wide meta-analysis of DNA methylation and childhood asthma
Epigenome-wide meta-analysis of DNA methylation and childhood asthma
Background Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. Objective We sought to identify differential DNA methylation in newborns and children related to childhood asthma. Methods Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally in school-aged children. We also identified differentially methylated regions. Results In newborns (8 cohorts, 668 cases), 9 CpGs (and 35 regions) were differentially methylated (epigenome-wide significance, false discovery rate < 0.05) in relation to asthma development. In a cross-sectional meta-analysis of asthma and methylation in children (9 cohorts, 631 cases), we identified 179 CpGs (false discovery rate < 0.05) and 36 differentially methylated regions. In replication studies of methylation in other tissues, most of the 179 CpGs discovered in blood replicated, despite smaller sample sizes, in studies of nasal respiratory epithelium or eosinophils. Pathway analyses highlighted enrichment for asthma-relevant immune processes and overlap in pathways enriched both in newborns and children. Gene expression correlated with methylation at most loci. Functional annotation supports a regulatory effect on gene expression at many asthma-associated CpGs. Several implicated genes are targets for approved or experimental drugs, including IL5RA and KCNH2. Conclusion Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age. Cross-sectional associations in children can reflect both risk for and effects of disease. Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.
0091-6749
2062-2074
Reese, Sarah E.
fed1b1a6-6d68-4069-b086-017f0f94a002
Xu, Cheng-Jian
1c4d76ae-4c68-4688-8ef6-88ef2529a436
Den Dekker, Herman T.
c1065246-99c7-480b-9b7b-fcafb2c96ccc
Lee, Mi Kyeong
f5884c1a-1b58-4901-a136-42e2b49874e1
Sikdar, Sinjini
c43b94aa-fd9b-4436-9ac1-90a20958cee2
Ruiz-Arenas, Carlos
e3ce90a5-40b4-48ab-be96-e4823f2798fc
Merid, Simon K.
c7eb7686-d1e1-45ed-93e3-e9f3e85ce197
Rezwan, Faisal I.
203f8f38-1f5d-485b-ab11-c546b4276338
Page, Christian M.
e257bad2-6515-4014-83ff-540c571b9c47
Ullemar, Vilhelmina
c98d98d3-3348-4ccf-aff2-343ae9988222
Melton, Phillip E.
0d57b167-a10c-4b22-83da-b983f378966f
Oh, Sam S.
827b9825-6bf1-49fb-a84a-45afa8e0e429
Yang, Ivana V.
ffb15dcd-ac2e-43bf-a2cc-443ff692f526
Burrows, Kimberley
3ad59faa-852a-4936-a512-0843073f8212
Söderhäll, Cilla
5117b3f6-4192-4cd7-b81f-427bead07bd0
Jima, Dereje D.
1a56553e-03d9-46d3-be53-6fd60ec12e40
Gao, Lu
80a9b183-04cb-42a6-9f2a-8ee86f5c25d6
Arathimos, Ryan
dd9cf1d5-d4d0-4338-a660-5aaf6f44b333
Küpers, Leanne K.
733e94ec-9e37-450c-a8ca-e1adf2eec323
Wielscher, Matthias
7ab47d0b-aa3a-43a3-8086-c6b980e56746
Rzehak, Peter
2f4a6676-3440-4e5f-b40f-1480dafac4dc
Lahti, Jari
230457a3-300b-4faf-810e-e2a07f57fcee
Laprise, Catherine
062920eb-611f-4177-bd4e-46fc2b01567a
Madore, Anne-Marie
ac19172c-8c57-4486-aa54-c6bbcfb5f2ce
Ward, James
35611092-46e8-43e1-bd4f-f3b92b3f9476
Bennett, Brian D.
49f54b8b-d9da-4293-bcd8-47bad03d36a4
Wang, Tianyuan
dc9da5d1-8c2d-4c99-9b4e-35eecc3c3fea
Bell, Douglas A.
7e7d03e9-b365-4df0-a786-22374aa58b8a
Vonk, Judith M.
8a2cadb9-0c50-4976-a718-6ccaa83a6b82
Håberg, Siri E.
63fa0e56-75ee-4fd3-9e3c-a5baa9d9e1ce
Zhao, Shanshan
48bce096-1c01-4f43-8009-ad6f7e81d8be
Karlsson, Robert
496ca473-fc2a-4a2c-8b39-c749be1f0317
Hollams, Elysia
66a9c95d-a883-4a1e-a387-5c3a20389b7b
Hu, Donglei
009a56fb-1b04-47b6-9717-e54854ae010c
Richards, Adam J.
6dc069c7-fa43-4e5f-a1a8-c6d441fcd612
Bergström, Anna
b7b8b4f8-15a5-4a0a-82db-28bfe3e6abc2
Sharp, Gemma C.
1ca7cdb0-ff2c-4679-b625-d00e347fd140
Felix, Janine F.
fcd2dff7-ebdf-40b3-8714-eeba5fa4818a
Bustamante, Mariona
fd901679-fcff-437d-acff-3bebcfc87be6
Gruzieva, Olena
0865d16b-2fdc-4e58-b834-a9fd22283ca5
Maguire, Rachel L.
7646cd55-7e04-4e70-af77-9601c9113c31
Gilliland, Frank
115cfcef-f3af-4dfa-b47a-fb06be81d2c1
Baïz, Nour
29c94ea0-77b3-4e8b-9a15-2b663acccf74
Nohr, Ellen A.
f2f79644-d9d9-4ef7-b9da-16997b5cd4a0
Corpeleijn, Eva
05909036-7f7f-4296-89f2-7a005feb5460
Sebert, Sylvain
d3f6c0f7-92b9-4959-a86c-9f7ad3346ee3
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Grote, Veit
9962d399-4c9f-4bf6-afa2-460f0d6dcd60
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Magnus, Maria C.
88cf8d2b-fe9d-49ad-b5c9-105f6bb36cec
Örtqvist, Anne K.
b969999c-ca42-4c89-87e7-c03127d918bd
Eng, Celeste
96fa93eb-5eeb-4542-adda-bda53cd735bf
Liu, Andrew H.
2864ca32-0d97-4d54-a8a6-210e35a0c837
Kull, Inger
a5927f4c-709a-4f6f-a576-a6c1200f4840
Jaddoe, Vincent W.V.
9a192cd2-9c0c-4d34-ad24-c6c4162e7b05
Sunyer, Jordi
d795b752-79fd-450c-814a-fc342e3b8efa
Kere, Juha
57c301de-f111-4552-a585-13eed945bdfc
Hoyo, Cathrine
2b25673d-5f67-47f8-9961-222a4f0bb516
Annesi-Maesano, Isabella
5cc6ea3c-5202-430d-8d5f-12eaebf251c0
Arshad, Syed Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Koletzko, Berthold
1932e5e8-b045-4e48-aa1e-5e4ea6803a69
Brunekreef, Bert
0131c22b-116e-4ec2-93a1-34632a2885f4
Binder, Elisabeth B.
96047fdc-dbd4-4864-b424-ab3d9da8012a
Räikkönen, Katri
32cd0aa3-6dc2-40a3-b1a0-245ccedd41c3
Reischl, Eva
7eeaa2a5-e8ea-4e16-bc0f-e378a15da660
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Jarvelin, Marjo-riitta
54bf0cc8-8f32-47db-b22d-6e694f1c1b26
Snieder, Harold
3ffb9ec7-cf11-4fff-8b45-02ba4d83a32e
Kazmi, Nabila
ae4d2d4d-3133-4b29-aa08-ad526681ea9b
Breton, Carrie V.
4a6d3cb3-49c2-44f6-b57f-c802bbd0917c
Murphy, Susan K.
5e25a27a-da84-4e47-b720-b51847971715
Pershagen, Göran
5680dad3-cd15-4752-a61a-49f3502953ef
Anto, Josep Maria
82c01d95-2583-49cd-a4f6-648e9374cb6f
Relton, Caroline L.
dcf42a2b-b423-4675-806d-bc581afe17a7
Schwartz, David A.
87755ee1-260c-44ea-933a-89fe1a835027
Burchard, Esteban G.
90dd2753-10ee-4651-b998-eba0440d36d5
Huang, Rae-Chi
d39aca4d-8017-48c3-8f40-0aa2e52dbf66
Nystad, Wenche
d23bedd0-f153-45a4-8160-9420c0129d52
Almqvist, Catarina
2b040b02-78fe-461e-adba-ed60d9f77ea0
Henderson, A. John
2053b8a0-1b2d-41f6-8b3f-1cf360c88c21
Melén, Erik
c7ee5423-aed5-4905-80b3-65bc07192e0c
Duijts, Liesbeth
9af3d956-5a40-4cd7-badd-542639c84460
Koppelman, Gerard H.
db8a0204-1f42-4273-a8a7-8575a43cd21f
London, Stephanie J.
320afdd8-d870-49a0-9f68-b409fb522e85
Reese, Sarah E.
fed1b1a6-6d68-4069-b086-017f0f94a002
Xu, Cheng-Jian
1c4d76ae-4c68-4688-8ef6-88ef2529a436
Den Dekker, Herman T.
c1065246-99c7-480b-9b7b-fcafb2c96ccc
Lee, Mi Kyeong
f5884c1a-1b58-4901-a136-42e2b49874e1
Sikdar, Sinjini
c43b94aa-fd9b-4436-9ac1-90a20958cee2
Ruiz-Arenas, Carlos
e3ce90a5-40b4-48ab-be96-e4823f2798fc
Merid, Simon K.
c7eb7686-d1e1-45ed-93e3-e9f3e85ce197
Rezwan, Faisal I.
203f8f38-1f5d-485b-ab11-c546b4276338
Page, Christian M.
e257bad2-6515-4014-83ff-540c571b9c47
Ullemar, Vilhelmina
c98d98d3-3348-4ccf-aff2-343ae9988222
Melton, Phillip E.
0d57b167-a10c-4b22-83da-b983f378966f
Oh, Sam S.
827b9825-6bf1-49fb-a84a-45afa8e0e429
Yang, Ivana V.
ffb15dcd-ac2e-43bf-a2cc-443ff692f526
Burrows, Kimberley
3ad59faa-852a-4936-a512-0843073f8212
Söderhäll, Cilla
5117b3f6-4192-4cd7-b81f-427bead07bd0
Jima, Dereje D.
1a56553e-03d9-46d3-be53-6fd60ec12e40
Gao, Lu
80a9b183-04cb-42a6-9f2a-8ee86f5c25d6
Arathimos, Ryan
dd9cf1d5-d4d0-4338-a660-5aaf6f44b333
Küpers, Leanne K.
733e94ec-9e37-450c-a8ca-e1adf2eec323
Wielscher, Matthias
7ab47d0b-aa3a-43a3-8086-c6b980e56746
Rzehak, Peter
2f4a6676-3440-4e5f-b40f-1480dafac4dc
Lahti, Jari
230457a3-300b-4faf-810e-e2a07f57fcee
Laprise, Catherine
062920eb-611f-4177-bd4e-46fc2b01567a
Madore, Anne-Marie
ac19172c-8c57-4486-aa54-c6bbcfb5f2ce
Ward, James
35611092-46e8-43e1-bd4f-f3b92b3f9476
Bennett, Brian D.
49f54b8b-d9da-4293-bcd8-47bad03d36a4
Wang, Tianyuan
dc9da5d1-8c2d-4c99-9b4e-35eecc3c3fea
Bell, Douglas A.
7e7d03e9-b365-4df0-a786-22374aa58b8a
Vonk, Judith M.
8a2cadb9-0c50-4976-a718-6ccaa83a6b82
Håberg, Siri E.
63fa0e56-75ee-4fd3-9e3c-a5baa9d9e1ce
Zhao, Shanshan
48bce096-1c01-4f43-8009-ad6f7e81d8be
Karlsson, Robert
496ca473-fc2a-4a2c-8b39-c749be1f0317
Hollams, Elysia
66a9c95d-a883-4a1e-a387-5c3a20389b7b
Hu, Donglei
009a56fb-1b04-47b6-9717-e54854ae010c
Richards, Adam J.
6dc069c7-fa43-4e5f-a1a8-c6d441fcd612
Bergström, Anna
b7b8b4f8-15a5-4a0a-82db-28bfe3e6abc2
Sharp, Gemma C.
1ca7cdb0-ff2c-4679-b625-d00e347fd140
Felix, Janine F.
fcd2dff7-ebdf-40b3-8714-eeba5fa4818a
Bustamante, Mariona
fd901679-fcff-437d-acff-3bebcfc87be6
Gruzieva, Olena
0865d16b-2fdc-4e58-b834-a9fd22283ca5
Maguire, Rachel L.
7646cd55-7e04-4e70-af77-9601c9113c31
Gilliland, Frank
115cfcef-f3af-4dfa-b47a-fb06be81d2c1
Baïz, Nour
29c94ea0-77b3-4e8b-9a15-2b663acccf74
Nohr, Ellen A.
f2f79644-d9d9-4ef7-b9da-16997b5cd4a0
Corpeleijn, Eva
05909036-7f7f-4296-89f2-7a005feb5460
Sebert, Sylvain
d3f6c0f7-92b9-4959-a86c-9f7ad3346ee3
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Grote, Veit
9962d399-4c9f-4bf6-afa2-460f0d6dcd60
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Magnus, Maria C.
88cf8d2b-fe9d-49ad-b5c9-105f6bb36cec
Örtqvist, Anne K.
b969999c-ca42-4c89-87e7-c03127d918bd
Eng, Celeste
96fa93eb-5eeb-4542-adda-bda53cd735bf
Liu, Andrew H.
2864ca32-0d97-4d54-a8a6-210e35a0c837
Kull, Inger
a5927f4c-709a-4f6f-a576-a6c1200f4840
Jaddoe, Vincent W.V.
9a192cd2-9c0c-4d34-ad24-c6c4162e7b05
Sunyer, Jordi
d795b752-79fd-450c-814a-fc342e3b8efa
Kere, Juha
57c301de-f111-4552-a585-13eed945bdfc
Hoyo, Cathrine
2b25673d-5f67-47f8-9961-222a4f0bb516
Annesi-Maesano, Isabella
5cc6ea3c-5202-430d-8d5f-12eaebf251c0
Arshad, Syed Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Koletzko, Berthold
1932e5e8-b045-4e48-aa1e-5e4ea6803a69
Brunekreef, Bert
0131c22b-116e-4ec2-93a1-34632a2885f4
Binder, Elisabeth B.
96047fdc-dbd4-4864-b424-ab3d9da8012a
Räikkönen, Katri
32cd0aa3-6dc2-40a3-b1a0-245ccedd41c3
Reischl, Eva
7eeaa2a5-e8ea-4e16-bc0f-e378a15da660
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Jarvelin, Marjo-riitta
54bf0cc8-8f32-47db-b22d-6e694f1c1b26
Snieder, Harold
3ffb9ec7-cf11-4fff-8b45-02ba4d83a32e
Kazmi, Nabila
ae4d2d4d-3133-4b29-aa08-ad526681ea9b
Breton, Carrie V.
4a6d3cb3-49c2-44f6-b57f-c802bbd0917c
Murphy, Susan K.
5e25a27a-da84-4e47-b720-b51847971715
Pershagen, Göran
5680dad3-cd15-4752-a61a-49f3502953ef
Anto, Josep Maria
82c01d95-2583-49cd-a4f6-648e9374cb6f
Relton, Caroline L.
dcf42a2b-b423-4675-806d-bc581afe17a7
Schwartz, David A.
87755ee1-260c-44ea-933a-89fe1a835027
Burchard, Esteban G.
90dd2753-10ee-4651-b998-eba0440d36d5
Huang, Rae-Chi
d39aca4d-8017-48c3-8f40-0aa2e52dbf66
Nystad, Wenche
d23bedd0-f153-45a4-8160-9420c0129d52
Almqvist, Catarina
2b040b02-78fe-461e-adba-ed60d9f77ea0
Henderson, A. John
2053b8a0-1b2d-41f6-8b3f-1cf360c88c21
Melén, Erik
c7ee5423-aed5-4905-80b3-65bc07192e0c
Duijts, Liesbeth
9af3d956-5a40-4cd7-badd-542639c84460
Koppelman, Gerard H.
db8a0204-1f42-4273-a8a7-8575a43cd21f
London, Stephanie J.
320afdd8-d870-49a0-9f68-b409fb522e85

Reese, Sarah E., Xu, Cheng-Jian, Den Dekker, Herman T., Lee, Mi Kyeong, Sikdar, Sinjini, Ruiz-Arenas, Carlos, Merid, Simon K., Rezwan, Faisal I., Page, Christian M., Ullemar, Vilhelmina, Melton, Phillip E., Oh, Sam S., Yang, Ivana V., Burrows, Kimberley, Söderhäll, Cilla, Jima, Dereje D., Gao, Lu, Arathimos, Ryan, Küpers, Leanne K., Wielscher, Matthias, Rzehak, Peter, Lahti, Jari, Laprise, Catherine, Madore, Anne-Marie, Ward, James, Bennett, Brian D., Wang, Tianyuan, Bell, Douglas A., Vonk, Judith M., Håberg, Siri E., Zhao, Shanshan, Karlsson, Robert, Hollams, Elysia, Hu, Donglei, Richards, Adam J., Bergström, Anna, Sharp, Gemma C., Felix, Janine F., Bustamante, Mariona, Gruzieva, Olena, Maguire, Rachel L., Gilliland, Frank, Baïz, Nour, Nohr, Ellen A., Corpeleijn, Eva, Sebert, Sylvain, Karmaus, Wilfried, Grote, Veit, Kajantie, Eero, Magnus, Maria C., Örtqvist, Anne K., Eng, Celeste, Liu, Andrew H., Kull, Inger, Jaddoe, Vincent W.V., Sunyer, Jordi, Kere, Juha, Hoyo, Cathrine, Annesi-Maesano, Isabella, Arshad, Syed Hasan, Koletzko, Berthold, Brunekreef, Bert, Binder, Elisabeth B., Räikkönen, Katri, Reischl, Eva, Holloway, John W., Jarvelin, Marjo-riitta, Snieder, Harold, Kazmi, Nabila, Breton, Carrie V., Murphy, Susan K., Pershagen, Göran, Anto, Josep Maria, Relton, Caroline L., Schwartz, David A., Burchard, Esteban G., Huang, Rae-Chi, Nystad, Wenche, Almqvist, Catarina, Henderson, A. John, Melén, Erik, Duijts, Liesbeth, Koppelman, Gerard H. and London, Stephanie J. (2019) Epigenome-wide meta-analysis of DNA methylation and childhood asthma. Journal of Allergy and Clinical Immunology, 143 (6), 2062-2074. (doi:10.1016/j.jaci.2018.11.043).

Record type: Article

Abstract

Background Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. Objective We sought to identify differential DNA methylation in newborns and children related to childhood asthma. Methods Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally in school-aged children. We also identified differentially methylated regions. Results In newborns (8 cohorts, 668 cases), 9 CpGs (and 35 regions) were differentially methylated (epigenome-wide significance, false discovery rate < 0.05) in relation to asthma development. In a cross-sectional meta-analysis of asthma and methylation in children (9 cohorts, 631 cases), we identified 179 CpGs (false discovery rate < 0.05) and 36 differentially methylated regions. In replication studies of methylation in other tissues, most of the 179 CpGs discovered in blood replicated, despite smaller sample sizes, in studies of nasal respiratory epithelium or eosinophils. Pathway analyses highlighted enrichment for asthma-relevant immune processes and overlap in pathways enriched both in newborns and children. Gene expression correlated with methylation at most loci. Functional annotation supports a regulatory effect on gene expression at many asthma-associated CpGs. Several implicated genes are targets for approved or experimental drugs, including IL5RA and KCNH2. Conclusion Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age. Cross-sectional associations in children can reflect both risk for and effects of disease. Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.

Text
1-s2.0-S009167491832788X-main - Accepted Manuscript
Download (32MB)
Text
1-s2.0-S009167491832788X-main - Version of Record
Available under License Creative Commons Attribution.
Download (1MB)

More information

Accepted/In Press date: 20 December 2018
e-pub ahead of print date: 21 December 2018
Published date: 1 June 2019

Identifiers

Local EPrints ID: 427174
URI: http://eprints.soton.ac.uk/id/eprint/427174
ISSN: 0091-6749
PURE UUID: c640defa-9d1d-4ff5-8fd2-c1cc582a331a
ORCID for Faisal I. Rezwan: ORCID iD orcid.org/0000-0001-9921-222X
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 04 Jan 2019 17:30
Last modified: 26 Nov 2021 05:13

Export record

Altmetrics

Contributors

Author: Sarah E. Reese
Author: Cheng-Jian Xu
Author: Herman T. Den Dekker
Author: Mi Kyeong Lee
Author: Sinjini Sikdar
Author: Carlos Ruiz-Arenas
Author: Simon K. Merid
Author: Faisal I. Rezwan ORCID iD
Author: Christian M. Page
Author: Vilhelmina Ullemar
Author: Phillip E. Melton
Author: Sam S. Oh
Author: Ivana V. Yang
Author: Kimberley Burrows
Author: Cilla Söderhäll
Author: Dereje D. Jima
Author: Lu Gao
Author: Ryan Arathimos
Author: Leanne K. Küpers
Author: Matthias Wielscher
Author: Peter Rzehak
Author: Jari Lahti
Author: Catherine Laprise
Author: Anne-Marie Madore
Author: James Ward
Author: Brian D. Bennett
Author: Tianyuan Wang
Author: Douglas A. Bell
Author: Judith M. Vonk
Author: Siri E. Håberg
Author: Shanshan Zhao
Author: Robert Karlsson
Author: Elysia Hollams
Author: Donglei Hu
Author: Adam J. Richards
Author: Anna Bergström
Author: Gemma C. Sharp
Author: Janine F. Felix
Author: Mariona Bustamante
Author: Olena Gruzieva
Author: Rachel L. Maguire
Author: Frank Gilliland
Author: Nour Baïz
Author: Ellen A. Nohr
Author: Eva Corpeleijn
Author: Sylvain Sebert
Author: Wilfried Karmaus
Author: Veit Grote
Author: Eero Kajantie
Author: Maria C. Magnus
Author: Anne K. Örtqvist
Author: Celeste Eng
Author: Andrew H. Liu
Author: Inger Kull
Author: Vincent W.V. Jaddoe
Author: Jordi Sunyer
Author: Juha Kere
Author: Cathrine Hoyo
Author: Isabella Annesi-Maesano
Author: Berthold Koletzko
Author: Bert Brunekreef
Author: Elisabeth B. Binder
Author: Katri Räikkönen
Author: Eva Reischl
Author: Marjo-riitta Jarvelin
Author: Harold Snieder
Author: Nabila Kazmi
Author: Carrie V. Breton
Author: Susan K. Murphy
Author: Göran Pershagen
Author: Josep Maria Anto
Author: Caroline L. Relton
Author: David A. Schwartz
Author: Esteban G. Burchard
Author: Rae-Chi Huang
Author: Wenche Nystad
Author: Catarina Almqvist
Author: A. John Henderson
Author: Erik Melén
Author: Liesbeth Duijts
Author: Gerard H. Koppelman
Author: Stephanie J. London

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×