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A time for everything and everything in its time – Exploring the mechanisms underlying seasonality of COPD exacerbations

A time for everything and everything in its time – Exploring the mechanisms underlying seasonality of COPD exacerbations
A time for everything and everything in its time – Exploring the mechanisms underlying seasonality of COPD exacerbations

Across Europe, COPD affects 23 million people leading to annual health care costs of ~€25.1 billion. This burden is particularly severe during winter months in association with the peak incidence of exacerbation events. Seasonal variation in the health status of patients with COPD places additional and often critical pressure on already strained health care resources. COPD exacerbations are characterized by worsening day-to-day symptoms of an individual and often triggered by respiratory infections, but the process by which this occurs in a seasonal fashion is likely to be multifactorial. In this review, we discuss recent population studies that highlight the impact of seasonality in COPD and review the proposed biological mechanisms underlying this. An appraisal of the role of the host susceptibility and response, environmental triggers and the biology of respiratory pathogens is detailed. The impact of each aspect is considered, and an integrated model of the context for the whole individual and society in general is explored.

Copd exacerbation, Pollution, Seasonality, Weather
1176-9106
2739-2749
Hicks, Alexander
d8d07898-d1ba-4428-b884-f929b65ae9ea
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
Sandeman, Natasha
2344e46c-4ecc-422f-b4bc-1dad233d7232
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Wilkinson, Tom
8c55ebbb-e547-445c-95a1-c8bed02dd652
Hicks, Alexander
d8d07898-d1ba-4428-b884-f929b65ae9ea
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
Sandeman, Natasha
2344e46c-4ecc-422f-b4bc-1dad233d7232
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Wilkinson, Tom
8c55ebbb-e547-445c-95a1-c8bed02dd652

Hicks, Alexander, Healy, Eugene, Sandeman, Natasha, Feelisch, Martin and Wilkinson, Tom (2018) A time for everything and everything in its time – Exploring the mechanisms underlying seasonality of COPD exacerbations. International Journal of COPD, 13, 2739-2749. (doi:10.2147/COPD.S146015).

Record type: Article

Abstract

Across Europe, COPD affects 23 million people leading to annual health care costs of ~€25.1 billion. This burden is particularly severe during winter months in association with the peak incidence of exacerbation events. Seasonal variation in the health status of patients with COPD places additional and often critical pressure on already strained health care resources. COPD exacerbations are characterized by worsening day-to-day symptoms of an individual and often triggered by respiratory infections, but the process by which this occurs in a seasonal fashion is likely to be multifactorial. In this review, we discuss recent population studies that highlight the impact of seasonality in COPD and review the proposed biological mechanisms underlying this. An appraisal of the role of the host susceptibility and response, environmental triggers and the biology of respiratory pathogens is detailed. The impact of each aspect is considered, and an integrated model of the context for the whole individual and society in general is explored.

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More information

Accepted/In Press date: 19 April 2018
e-pub ahead of print date: 5 September 2018
Published date: 2018
Keywords: Copd exacerbation, Pollution, Seasonality, Weather

Identifiers

Local EPrints ID: 427257
URI: http://eprints.soton.ac.uk/id/eprint/427257
ISSN: 1176-9106
PURE UUID: a7bfbca4-d636-41f9-9ee1-cad9d7bad1cd
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 10 Jan 2019 17:30
Last modified: 26 Nov 2021 02:58

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Contributors

Author: Alexander Hicks
Author: Eugene Healy
Author: Natasha Sandeman
Author: Martin Feelisch ORCID iD
Author: Tom Wilkinson

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