The University of Southampton
University of Southampton Institutional Repository

Outcomes following percutaneous coronary intervention in non-ST-segment-elevation myocardial infarction patients with coronary artery bypass grafts

Outcomes following percutaneous coronary intervention in non-ST-segment-elevation myocardial infarction patients with coronary artery bypass grafts
Outcomes following percutaneous coronary intervention in non-ST-segment-elevation myocardial infarction patients with coronary artery bypass grafts

Background: There are limited data on outcomes of patients with previous coronary artery bypass graft (CABG) presenting with non-ST-segment-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI). We compare clinical characteristics and outcomes in non-ST-segment-elevation myocardial infarction patients undergoing PCI with or without prior CABG surgery in a national cohort.

 Methods and Results: We identified 205 039 patients with non-ST-segment-elevation myocardial infarction who underwent PCI between 2007 and 2014 in the British Cardiovascular Intervention Society database. Clinical, demographic, procedural, and outcome data were analyzed by dividing into 3 groups: group 1, PCI in native coronary arteries and no prior CABG (n=186 670); group 2, PCI in native arteries with prior CABG (n=8825); group 3, PCI in grafts (n=9544). Patients in group 2 and 3 were older and had more comorbidities and higher mortality at 30 days (group 2, 2.6% and group 3, 1.9%) and 1 year (group 2, 8.29% and group 3, 7.08%) as compared with group 1 (1.7% and 4.87%). After multivariable analysis, no significant difference in outcomes was observed in 30-days mortality (odds ratio; group 2=0.87 [CI, 0.69-1.80; P=0.20], group 3=0.91 [CI, 0.71-1.17; P=0.46]), in-hospital major adverse cardiovascular event (odds ratio: group 2=1.08 [CI, 0.88-1.34; P=0.45], group 3=0.97 [CI=0.77-1.23; P=0.82]), and in-hospital stroke (odds ratio: group 2=1.37 [CI, 0.71-2.69; P=0.35], group 3=1.13 [CI, 0.55-2.34; P=0.73]; group 1=reference). 

Conclusions: Patients with prior CABG are presenting with non-ST-segment-elevation myocardial infarction and treated with PCI had more comorbid illnesses, but once these differences were adjusted for, prior CABG did not independently confer additional risk of mortality and major adverse cardiovascular event.

comorbidity, coronary artery disease, mortality, myocardial infarction, percutaneous coronary intervention
1941-7640
e006824
Shoaib, Ahmad
87d9fdcb-a5ce-4379-8280-3115040dc364
Kinnaird, Tim
3cfe5aa5-eb28-4a4d-b2e4-6ea0799d85d0
Curzen, Nick
70f3ea49-51b1-418f-8e56-8210aef1abf4
Kontopantelis, Evangelos
0a21ca6f-4516-45f8-80fc-b10dd7db6780
Ludman, Peter
28ef305d-e09e-40a7-84b4-6ccedfb37cc8
de Belder, Mark
3d0eff51-f1d1-41a7-aac1-e193db082360
Rashid, Muhammad
f974c0d2-bd55-4d93-940e-1cce3dd0fd59
Kwok, Chun Shing
000170fb-8506-4c19-9481-e56d93049fef
Nolan, James
1cdb1e12-958f-4b04-a730-242dd48591b1
Zaman, Azfar
1eb39d94-fdb9-466b-ab6c-7613255baf80
Mamas, Mamas A.
41515b72-75ff-4922-bb9f-8f9c63f9f5af
Shoaib, Ahmad
87d9fdcb-a5ce-4379-8280-3115040dc364
Kinnaird, Tim
3cfe5aa5-eb28-4a4d-b2e4-6ea0799d85d0
Curzen, Nick
70f3ea49-51b1-418f-8e56-8210aef1abf4
Kontopantelis, Evangelos
0a21ca6f-4516-45f8-80fc-b10dd7db6780
Ludman, Peter
28ef305d-e09e-40a7-84b4-6ccedfb37cc8
de Belder, Mark
3d0eff51-f1d1-41a7-aac1-e193db082360
Rashid, Muhammad
f974c0d2-bd55-4d93-940e-1cce3dd0fd59
Kwok, Chun Shing
000170fb-8506-4c19-9481-e56d93049fef
Nolan, James
1cdb1e12-958f-4b04-a730-242dd48591b1
Zaman, Azfar
1eb39d94-fdb9-466b-ab6c-7613255baf80
Mamas, Mamas A.
41515b72-75ff-4922-bb9f-8f9c63f9f5af

Shoaib, Ahmad, Kinnaird, Tim, Curzen, Nick, Kontopantelis, Evangelos, Ludman, Peter, de Belder, Mark, Rashid, Muhammad, Kwok, Chun Shing, Nolan, James, Zaman, Azfar and Mamas, Mamas A. (2018) Outcomes following percutaneous coronary intervention in non-ST-segment-elevation myocardial infarction patients with coronary artery bypass grafts. Circulation. Cardiovascular interventions, 11 (11), e006824. (doi:10.1161/CIRCINTERVENTIONS.118.006824).

Record type: Article

Abstract

Background: There are limited data on outcomes of patients with previous coronary artery bypass graft (CABG) presenting with non-ST-segment-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI). We compare clinical characteristics and outcomes in non-ST-segment-elevation myocardial infarction patients undergoing PCI with or without prior CABG surgery in a national cohort.

 Methods and Results: We identified 205 039 patients with non-ST-segment-elevation myocardial infarction who underwent PCI between 2007 and 2014 in the British Cardiovascular Intervention Society database. Clinical, demographic, procedural, and outcome data were analyzed by dividing into 3 groups: group 1, PCI in native coronary arteries and no prior CABG (n=186 670); group 2, PCI in native arteries with prior CABG (n=8825); group 3, PCI in grafts (n=9544). Patients in group 2 and 3 were older and had more comorbidities and higher mortality at 30 days (group 2, 2.6% and group 3, 1.9%) and 1 year (group 2, 8.29% and group 3, 7.08%) as compared with group 1 (1.7% and 4.87%). After multivariable analysis, no significant difference in outcomes was observed in 30-days mortality (odds ratio; group 2=0.87 [CI, 0.69-1.80; P=0.20], group 3=0.91 [CI, 0.71-1.17; P=0.46]), in-hospital major adverse cardiovascular event (odds ratio: group 2=1.08 [CI, 0.88-1.34; P=0.45], group 3=0.97 [CI=0.77-1.23; P=0.82]), and in-hospital stroke (odds ratio: group 2=1.37 [CI, 0.71-2.69; P=0.35], group 3=1.13 [CI, 0.55-2.34; P=0.73]; group 1=reference). 

Conclusions: Patients with prior CABG are presenting with non-ST-segment-elevation myocardial infarction and treated with PCI had more comorbid illnesses, but once these differences were adjusted for, prior CABG did not independently confer additional risk of mortality and major adverse cardiovascular event.

This record has no associated files available for download.

More information

Accepted/In Press date: 12 September 2018
e-pub ahead of print date: 16 November 2018
Published date: November 2018
Keywords: comorbidity, coronary artery disease, mortality, myocardial infarction, percutaneous coronary intervention

Identifiers

Local EPrints ID: 427269
URI: http://eprints.soton.ac.uk/id/eprint/427269
ISSN: 1941-7640
PURE UUID: d7dfce32-4bbb-430a-a784-98739bb33d18
ORCID for Nick Curzen: ORCID iD orcid.org/0000-0001-9651-7829

Catalogue record

Date deposited: 10 Jan 2019 17:30
Last modified: 11 May 2024 01:40

Export record

Altmetrics

Contributors

Author: Ahmad Shoaib
Author: Tim Kinnaird
Author: Nick Curzen ORCID iD
Author: Evangelos Kontopantelis
Author: Peter Ludman
Author: Mark de Belder
Author: Muhammad Rashid
Author: Chun Shing Kwok
Author: James Nolan
Author: Azfar Zaman
Author: Mamas A. Mamas

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×