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Barriers to the release of human tissue for clinical trials research in the UK: a national survey of cellular pathology laboratories on behalf of the National Cancer Research Institute's Cellular Molecular Pathology (CM-Path) initiative

Barriers to the release of human tissue for clinical trials research in the UK: a national survey of cellular pathology laboratories on behalf of the National Cancer Research Institute's Cellular Molecular Pathology (CM-Path) initiative
Barriers to the release of human tissue for clinical trials research in the UK: a national survey of cellular pathology laboratories on behalf of the National Cancer Research Institute's Cellular Molecular Pathology (CM-Path) initiative

Aim: To survey UK cellular pathology departments regarding their attitudes and practices relating to release of human tissue from their diagnostic archives for use in clinical trial research. Methods: A 30-item questionnaire was circulated to the National Cancer Research Institute's Cellular Molecular Pathology initiative and Confederation of Cancer Biobanks mailing lists. Responses were collected over a 10-month period from November 2016 to August 2017. Results: 38 departments responded to the survey, the majority of which regularly receive requests for tissue for research purposes. Most requests come from academia and financial support to facilitate tissue release comes from a variety of sources. A range of practices were reported in relation to selection of the most appropriate sample to release, consent checking, costing and governance frameworks. Conclusions: This survey demonstrates wide variation in practice across the UK and identifies barriers to release of human tissue for clinical trial research. Until we can overcome these obstacles, patient samples will remain inaccessible to research. Therefore, this study highlights the urgent need for clear and coordinated national guidance on this issue.

cancer, cancer research, laboratory management
0021-9746
52-57
Macklin, Philip S.
3e13c44c-746e-4caf-b7d7-8ee6cd92b95a
Hall, Andrew
d88caf4d-4d33-49fe-a7de-d837dee8a1d9
Lee, Jessica
0c9ab325-5fa3-4155-b61e-11c82a9a4e82
Hair, Jane
37b7a1c3-b0f6-4799-aa04-d56d8d8ce6cd
Speirs, Valerie
aa8448ce-da72-4b1a-a5e8-b0ae5de96394
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Oien, Karin A.
e7577158-717e-42e4-b144-460763bbdc38
Verrill, Clare
aebaa0d4-fb62-4bf6-97ab-5f9bb23cf9a3
Macklin, Philip S.
3e13c44c-746e-4caf-b7d7-8ee6cd92b95a
Hall, Andrew
d88caf4d-4d33-49fe-a7de-d837dee8a1d9
Lee, Jessica
0c9ab325-5fa3-4155-b61e-11c82a9a4e82
Hair, Jane
37b7a1c3-b0f6-4799-aa04-d56d8d8ce6cd
Speirs, Valerie
aa8448ce-da72-4b1a-a5e8-b0ae5de96394
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Oien, Karin A.
e7577158-717e-42e4-b144-460763bbdc38
Verrill, Clare
aebaa0d4-fb62-4bf6-97ab-5f9bb23cf9a3

Macklin, Philip S., Hall, Andrew, Lee, Jessica, Hair, Jane, Speirs, Valerie, Thomas, Gareth J., Oien, Karin A. and Verrill, Clare (2019) Barriers to the release of human tissue for clinical trials research in the UK: a national survey of cellular pathology laboratories on behalf of the National Cancer Research Institute's Cellular Molecular Pathology (CM-Path) initiative. Journal of Clinical Pathology, 72 (1), 52-57. (doi:10.1136/jclinpath-2018-205476).

Record type: Article

Abstract

Aim: To survey UK cellular pathology departments regarding their attitudes and practices relating to release of human tissue from their diagnostic archives for use in clinical trial research. Methods: A 30-item questionnaire was circulated to the National Cancer Research Institute's Cellular Molecular Pathology initiative and Confederation of Cancer Biobanks mailing lists. Responses were collected over a 10-month period from November 2016 to August 2017. Results: 38 departments responded to the survey, the majority of which regularly receive requests for tissue for research purposes. Most requests come from academia and financial support to facilitate tissue release comes from a variety of sources. A range of practices were reported in relation to selection of the most appropriate sample to release, consent checking, costing and governance frameworks. Conclusions: This survey demonstrates wide variation in practice across the UK and identifies barriers to release of human tissue for clinical trial research. Until we can overcome these obstacles, patient samples will remain inaccessible to research. Therefore, this study highlights the urgent need for clear and coordinated national guidance on this issue.

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More information

Accepted/In Press date: 5 September 2018
e-pub ahead of print date: 1 October 2018
Published date: January 2019
Keywords: cancer, cancer research, laboratory management

Identifiers

Local EPrints ID: 427325
URI: https://eprints.soton.ac.uk/id/eprint/427325
ISSN: 0021-9746
PURE UUID: 0e051194-744d-41f5-a3a1-cccb92089e68

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Date deposited: 11 Jan 2019 17:30
Last modified: 11 Jan 2019 17:30

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