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Proactive multi-modality treatment of Pancreatic Neuroendocrine Tumours (PNETs): Potential survival benefits

Proactive multi-modality treatment of Pancreatic Neuroendocrine Tumours (PNETs): Potential survival benefits
Proactive multi-modality treatment of Pancreatic Neuroendocrine Tumours (PNETs): Potential survival benefits

Background/objectives

Primary and metastatic pancreatic neuroendocrine tumours (PNET) can be treated with combination of surgery, locoregional and systemic therapy. Survival benefits from individual treatments have been well reported, however, the combined outcome from multimodal treatments are not well described in the literature. We report outcomes in a cohort of PNET patients treated with proactive, multimodality therapy.


Methods

106 patients were identified from a single tertiary referral centre prospective database. Outcomes of treatment were studied, with the primary end point being death from any cause.


Results

Median follow-up was 71 months and overall 5-year survival of 62%. In patients with stage I-III disease (51 patients) estimated 5-year survival was 90%. Median survival in patients with stage IV disease was 51 months with an estimated 5-year survival of 40% in this group. A total of 80 patients (75%) had surgery of which 16% suffered complications requiring intervention. There was no perioperative mortality.


Conclusions

This study demonstrates that proactive multimodal treatment is safe and may confer a survival benefit to patients in this cohort
1424-3903
304-312
Tanno, L.
b1e0f618-9918-428a-88c7-52846c2b8a64
Mayo, D.
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Mills, S.
e62e70ad-5e1d-4e51-a57e-028a6d412df2
Takhar, A.
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Cave, J.
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Nolan, L.
8711336e-dc97-46b4-b2f3-186bca774cc3
Stedman, B.
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Sundram, F.X.
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Abu Hilal, M.
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Connor, H.
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Pearce, N.
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Armstrong, T.
fe074aba-a53c-4db6-b007-af761cd75235
Tanno, L.
b1e0f618-9918-428a-88c7-52846c2b8a64
Mayo, D.
7e2ca070-e4ce-40e5-8f9e-fc68e477b0a6
Mills, S.
e62e70ad-5e1d-4e51-a57e-028a6d412df2
Takhar, A.
9ed235ad-3b40-40b0-bb76-bfce5b427b71
Cave, J.
fa0405c9-9597-43f6-a9f4-b9ec5fb7268f
Nolan, L.
8711336e-dc97-46b4-b2f3-186bca774cc3
Stedman, B.
58aa88de-d498-4f8b-8d91-83545f28c7e5
Sundram, F.X.
a4bf1977-fa00-4f56-962b-7f039be7714e
Abu Hilal, M.
384e1c60-8519-4eed-8e92-91775aad4c47
Connor, H.
20a0be25-7183-44ce-9d06-e57c610e5241
Pearce, N.
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Armstrong, T.
fe074aba-a53c-4db6-b007-af761cd75235

Tanno, L., Mayo, D., Mills, S., Takhar, A., Cave, J., Nolan, L., Stedman, B., Sundram, F.X., Abu Hilal, M., Connor, H., Pearce, N. and Armstrong, T. (2018) Proactive multi-modality treatment of Pancreatic Neuroendocrine Tumours (PNETs): Potential survival benefits. Pancreatology, 18 (3), 304-312. (doi:10.1016/j.pan.2017.12.006).

Record type: Article

Abstract


Background/objectives

Primary and metastatic pancreatic neuroendocrine tumours (PNET) can be treated with combination of surgery, locoregional and systemic therapy. Survival benefits from individual treatments have been well reported, however, the combined outcome from multimodal treatments are not well described in the literature. We report outcomes in a cohort of PNET patients treated with proactive, multimodality therapy.


Methods

106 patients were identified from a single tertiary referral centre prospective database. Outcomes of treatment were studied, with the primary end point being death from any cause.


Results

Median follow-up was 71 months and overall 5-year survival of 62%. In patients with stage I-III disease (51 patients) estimated 5-year survival was 90%. Median survival in patients with stage IV disease was 51 months with an estimated 5-year survival of 40% in this group. A total of 80 patients (75%) had surgery of which 16% suffered complications requiring intervention. There was no perioperative mortality.


Conclusions

This study demonstrates that proactive multimodal treatment is safe and may confer a survival benefit to patients in this cohort

Full text not available from this repository.

More information

Accepted/In Press date: 11 December 2017
e-pub ahead of print date: 14 December 2017
Published date: April 2018

Identifiers

Local EPrints ID: 427401
URI: https://eprints.soton.ac.uk/id/eprint/427401
ISSN: 1424-3903
PURE UUID: c91250bd-361f-407a-9f8d-d1dda354bb45

Catalogue record

Date deposited: 15 Jan 2019 17:30
Last modified: 15 Jan 2019 17:30

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Contributors

Author: L. Tanno
Author: D. Mayo
Author: S. Mills
Author: A. Takhar
Author: J. Cave
Author: L. Nolan
Author: B. Stedman
Author: F.X. Sundram
Author: M. Abu Hilal
Author: H. Connor
Author: N. Pearce
Author: T. Armstrong

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