Targeted therapeutics for lymphoma: Using biology to inform treatment
Targeted therapeutics for lymphoma: Using biology to inform treatment
A significant proportion of patients with B- and T-cell aggressive non-Hodgkin lymphomas are not cured by standard of care immunochemotherapy, and recent randomised studies have failed to improve outcomes for patients with the most common type, diffuse large B-cell lymphoma. Advances in molecular biology have confirmed aggressive lymphomas to be molecularly heterogeneous, but at present biological knowledge provides limited guidance for clinical practice. This is likely to change as discovery science and targeted therapies in clinical trials begin to identify subtypes that may respond differentially to specific treatments. This chapter reviews the evidence to date and the prospects for changes to clinical practice in the future.
343-360
Cummin, Thomas
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Cragg, Mark
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Friedberg, Jonathan W.
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Johnson, Peter
3f6068ce-171e-4c2c-aca9-dc9b6a37413f
2019
Cummin, Thomas
fcce88a2-7ed7-4bde-a5f5-3f3c834382a4
Cragg, Mark
ec97f80e-f3c8-49b7-a960-20dff648b78c
Friedberg, Jonathan W.
734260ab-161f-4f22-ba92-f446fcd02d16
Johnson, Peter
3f6068ce-171e-4c2c-aca9-dc9b6a37413f
Cummin, Thomas, Cragg, Mark, Friedberg, Jonathan W. and Johnson, Peter
(2019)
Targeted therapeutics for lymphoma: Using biology to inform treatment.
In,
Lenz, Georg and Salles, Gilles
(eds.)
Agressive Lymphomas.
(Hematologic Malignancies)
1 ed.
Cham.
Springer, .
Record type:
Book Section
Abstract
A significant proportion of patients with B- and T-cell aggressive non-Hodgkin lymphomas are not cured by standard of care immunochemotherapy, and recent randomised studies have failed to improve outcomes for patients with the most common type, diffuse large B-cell lymphoma. Advances in molecular biology have confirmed aggressive lymphomas to be molecularly heterogeneous, but at present biological knowledge provides limited guidance for clinical practice. This is likely to change as discovery science and targeted therapies in clinical trials begin to identify subtypes that may respond differentially to specific treatments. This chapter reviews the evidence to date and the prospects for changes to clinical practice in the future.
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Targeted Therapeutics for Lymphoma Using Biology to Inform Treatment
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e-pub ahead of print date: 28 December 2018
Published date: 2019
Identifiers
Local EPrints ID: 427407
URI: http://eprints.soton.ac.uk/id/eprint/427407
ISSN: 2197-9766
PURE UUID: 94c20820-608f-4e25-8638-28ff11491df7
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Date deposited: 15 Jan 2019 17:30
Last modified: 16 Mar 2024 03:00
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Contributors
Author:
Thomas Cummin
Author:
Jonathan W. Friedberg
Editor:
Georg Lenz
Editor:
Gilles Salles
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