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Myoglobin and troponin concentrations are increased in early stage deep tissue injury

Myoglobin and troponin concentrations are increased in early stage deep tissue injury
Myoglobin and troponin concentrations are increased in early stage deep tissue injury

Pressure-induced deep tissue injury is a form of pressure ulcer which is difficult to detect and diagnose at an early stage, before the wound has severely progressed and becomes visible at the skin surface. At the present time, no such detection technique is available. To test the hypothesis that muscle damage biomarkers can be indicative of the development of deep tissue injury after sustained mechanical loading, an indentation test was performed for 2 h on the tibialis anterior muscle of rats. Myoglobin and troponin were analysed in blood plasma and urine over a period of 5 days. The damage as detected by the biomarkers was compared to damage as observed with T2 MRI to validate the response. We found that myoglobin and troponin levels in blood increased due to the damage. Myoglobin was also increased in urine. The amount of damage observed with MRI immediately after loading had a strong correlation with the maximal biomarker levels: troponin in blood rs = 0.94; myoglobin in blood rs = 0.75; and myoglobin in urine rs = 0.57. This study suggests that muscle damage markers measured in blood and urine could serve as early diagnosis for pressure induced deep tissue injury.

Biomarkers, Deep tissue injury, Magnetic resonance imaging, Pressure ulcers, Skeletal muscle damage
1751-6161
50-57
Traa, W. A.
7133843c-25e6-456b-b472-a70e15ba9f28
Strijkers, G. J.
c8506691-27fd-48f5-9ba9-174ba3feed28
Bader, D. L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Oomens, C. W.J.
b4884336-5230-4055-9df2-5400c1c57018
Traa, W. A.
7133843c-25e6-456b-b472-a70e15ba9f28
Strijkers, G. J.
c8506691-27fd-48f5-9ba9-174ba3feed28
Bader, D. L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Oomens, C. W.J.
b4884336-5230-4055-9df2-5400c1c57018

Traa, W. A., Strijkers, G. J., Bader, D. L. and Oomens, C. W.J. (2019) Myoglobin and troponin concentrations are increased in early stage deep tissue injury. Journal of the Mechanical Behavior of Biomedical Materials, 92, 50-57. (doi:10.1016/j.jmbbm.2018.12.026).

Record type: Article

Abstract

Pressure-induced deep tissue injury is a form of pressure ulcer which is difficult to detect and diagnose at an early stage, before the wound has severely progressed and becomes visible at the skin surface. At the present time, no such detection technique is available. To test the hypothesis that muscle damage biomarkers can be indicative of the development of deep tissue injury after sustained mechanical loading, an indentation test was performed for 2 h on the tibialis anterior muscle of rats. Myoglobin and troponin were analysed in blood plasma and urine over a period of 5 days. The damage as detected by the biomarkers was compared to damage as observed with T2 MRI to validate the response. We found that myoglobin and troponin levels in blood increased due to the damage. Myoglobin was also increased in urine. The amount of damage observed with MRI immediately after loading had a strong correlation with the maximal biomarker levels: troponin in blood rs = 0.94; myoglobin in blood rs = 0.75; and myoglobin in urine rs = 0.57. This study suggests that muscle damage markers measured in blood and urine could serve as early diagnosis for pressure induced deep tissue injury.

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Accepted/In Press date: 20 December 2018
e-pub ahead of print date: 21 December 2018
Published date: 1 April 2019
Keywords: Biomarkers, Deep tissue injury, Magnetic resonance imaging, Pressure ulcers, Skeletal muscle damage

Identifiers

Local EPrints ID: 427506
URI: http://eprints.soton.ac.uk/id/eprint/427506
ISSN: 1751-6161
PURE UUID: 5051ff5a-94e1-406a-bbdb-b20661ec66ad
ORCID for D. L. Bader: ORCID iD orcid.org/0000-0002-1208-3507

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Date deposited: 22 Jan 2019 17:30
Last modified: 09 Jan 2022 03:36

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Contributors

Author: W. A. Traa
Author: G. J. Strijkers
Author: D. L. Bader ORCID iD
Author: C. W.J. Oomens

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