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Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives

Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives
Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives
Novel 2-substituted isobutyric acid derivatives were synthesized and their hypolipidemic activity was evaluated in high cholesterol diet fed rat model. The amide 5a was found to decrease the levels of serum total cholesterol, LDL cholesterol and triglycerides in hyperlipidemic rats to a greater degree than the reference gemfibrozil.
0223-5234
2679-2684
Moustafa, Gamal A. I.
1a452cdc-4856-4243-9864-b391fb115f07
Abuo-Rahma, Gamal
5d462117-abf6-4a54-afe5-f872ae6668a5
Aly, Omar
5ff1e4b4-b4bd-4430-a329-0528e92e87cf
Radwan, Mohamed
6b49cbce-4d3c-4486-8597-94d4bd4cf338
Moustafa, Gamal A. I.
1a452cdc-4856-4243-9864-b391fb115f07
Abuo-Rahma, Gamal
5d462117-abf6-4a54-afe5-f872ae6668a5
Aly, Omar
5ff1e4b4-b4bd-4430-a329-0528e92e87cf
Radwan, Mohamed
6b49cbce-4d3c-4486-8597-94d4bd4cf338

Moustafa, Gamal A. I., Abuo-Rahma, Gamal, Aly, Omar and Radwan, Mohamed (2009) Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives. European Journal of Medicinal Chemistry, 44 (6), 2679-2684. (doi:10.1016/j.ejmech.2008.12.009).

Record type: Article

Abstract

Novel 2-substituted isobutyric acid derivatives were synthesized and their hypolipidemic activity was evaluated in high cholesterol diet fed rat model. The amide 5a was found to decrease the levels of serum total cholesterol, LDL cholesterol and triglycerides in hyperlipidemic rats to a greater degree than the reference gemfibrozil.

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More information

Accepted/In Press date: 8 December 2008
e-pub ahead of print date: 24 December 2008
Published date: 2009

Identifiers

Local EPrints ID: 427580
URI: http://eprints.soton.ac.uk/id/eprint/427580
DOI: doi:10.1016/j.ejmech.2008.12.009
ISSN: 0223-5234
PURE UUID: a3d52981-f6d3-4d1d-b27e-005f8a8a6b73
ORCID for Gamal A. I. Moustafa: ORCID iD orcid.org/0000-0002-9940-0033

Catalogue record

Date deposited: 23 Jan 2019 17:30
Last modified: 16 Mar 2024 04:40

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Contributors

Author: Gamal A. I. Moustafa ORCID iD
Author: Gamal Abuo-Rahma
Author: Omar Aly
Author: Mohamed Radwan

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