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New norfloxacin/nitric oxide donor hybrids: Synthesis and nitric oxide release measurement using a modified Griess colorimetric method

New norfloxacin/nitric oxide donor hybrids: Synthesis and nitric oxide release measurement using a modified Griess colorimetric method
New norfloxacin/nitric oxide donor hybrids: Synthesis and nitric oxide release measurement using a modified Griess colorimetric method
Oximes and nitrate esters are considered as important nitric oxide (NO) donors with diverse biological activities. Herein, we report the synthesis and characterization of new oxime and nitrate ester derivatives of norfloxacin as potential NO donor hybrids with expected synergistic antimicrobial activity. The release of NO from those hybrids was measured by a modified Griess method in which p-nitroaniline was employed instead of sulfanilamide. The increased electrophilicity of the intermediate 4-nitroaniline diazonium salt accelerated the coupling process and shortened the overall assessment time. The improved detection limits and enhanced sensitivity would pave the way for the future application of this method in nitrite determination in biological or non-biological systems.
119-124
Aziz, Hossameldin
c5507861-a494-42b2-941b-9d3776ddfda0
Moustafa, Gamal A. I.
1a452cdc-4856-4243-9864-b391fb115f07
Abbas, Samar
f1a0c890-9b50-4d32-ad07-9c0b49e2784b
Derayea, Sayed
94ef8c13-b418-44fc-9c67-8a99df71ffd5
Abuo-Rahma, Gamal
b964d0a7-df3c-4f6f-9f60-0bda1234c0e2
Aziz, Hossameldin
c5507861-a494-42b2-941b-9d3776ddfda0
Moustafa, Gamal A. I.
1a452cdc-4856-4243-9864-b391fb115f07
Abbas, Samar
f1a0c890-9b50-4d32-ad07-9c0b49e2784b
Derayea, Sayed
94ef8c13-b418-44fc-9c67-8a99df71ffd5
Abuo-Rahma, Gamal
b964d0a7-df3c-4f6f-9f60-0bda1234c0e2

Aziz, Hossameldin, Moustafa, Gamal A. I., Abbas, Samar, Derayea, Sayed and Abuo-Rahma, Gamal (2017) New norfloxacin/nitric oxide donor hybrids: Synthesis and nitric oxide release measurement using a modified Griess colorimetric method. European Journal of Chemistry, 8 (2), 119-124. (doi:10.5155/eurjchem.8.2.119-124.1549).

Record type: Article

Abstract

Oximes and nitrate esters are considered as important nitric oxide (NO) donors with diverse biological activities. Herein, we report the synthesis and characterization of new oxime and nitrate ester derivatives of norfloxacin as potential NO donor hybrids with expected synergistic antimicrobial activity. The release of NO from those hybrids was measured by a modified Griess method in which p-nitroaniline was employed instead of sulfanilamide. The increased electrophilicity of the intermediate 4-nitroaniline diazonium salt accelerated the coupling process and shortened the overall assessment time. The improved detection limits and enhanced sensitivity would pave the way for the future application of this method in nitrite determination in biological or non-biological systems.

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More information

Accepted/In Press date: 13 March 2017
e-pub ahead of print date: 30 June 2017
Published date: 2017

Identifiers

Local EPrints ID: 427588
URI: http://eprints.soton.ac.uk/id/eprint/427588
PURE UUID: bb90bf6a-1077-4efb-9189-a9dab87b88bf

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Date deposited: 23 Jan 2019 17:30
Last modified: 07 Aug 2020 16:34

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Contributors

Author: Hossameldin Aziz
Author: Samar Abbas
Author: Sayed Derayea
Author: Gamal Abuo-Rahma

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