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Development of a global quantitative proteomics methodology and clinical applications in chronic diseases

Development of a global quantitative proteomics methodology and clinical applications in chronic diseases
Development of a global quantitative proteomics methodology and clinical applications in chronic diseases
Shotgun proteomics refers to the untargeted and unbiased analysis of the global proteome as this occurs in a biological system. The overarching aim of my research is to develop a proteomics methodology for the in-depth profiling of tissue and cell-lines and apply this novel methodology in mouse model and human samples in order to identify molecular mechanisms and novel therapeutic targets of obesity and obesity-related chronic diseases, including Alzheimer’s disease and oesophageal adenocarcinoma.

The innovative quantitative proteomics methodology we developed for the global, untargeted proteomic profiling of cell lines and tissue has wide applications in different subject areas of biomedical research. Depending on the samples analysed and experimental design, this methodological approach can provide novel insight into physiological processes, the pathophysiology of disease, as well as identify novel therapeutic targets and disease markers.
University of Southampton
Manousopoulou, Antigoni
4e4b92ba-be65-4dba-a15d-87924c56f08b
Manousopoulou, Antigoni
4e4b92ba-be65-4dba-a15d-87924c56f08b
Carare, Roxana-Octavia
0478c197-b0c1-4206-acae-54e88c8f21fa

Manousopoulou, Antigoni (2018) Development of a global quantitative proteomics methodology and clinical applications in chronic diseases. University of Southampton, Doctoral Thesis, 108pp.

Record type: Thesis (Doctoral)

Abstract

Shotgun proteomics refers to the untargeted and unbiased analysis of the global proteome as this occurs in a biological system. The overarching aim of my research is to develop a proteomics methodology for the in-depth profiling of tissue and cell-lines and apply this novel methodology in mouse model and human samples in order to identify molecular mechanisms and novel therapeutic targets of obesity and obesity-related chronic diseases, including Alzheimer’s disease and oesophageal adenocarcinoma.

The innovative quantitative proteomics methodology we developed for the global, untargeted proteomic profiling of cell lines and tissue has wide applications in different subject areas of biomedical research. Depending on the samples analysed and experimental design, this methodological approach can provide novel insight into physiological processes, the pathophysiology of disease, as well as identify novel therapeutic targets and disease markers.

Text
A. Manousopoulou PhD - Version of Record
Available under License University of Southampton Thesis Licence.
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Published date: July 2018

Identifiers

Local EPrints ID: 427726
URI: http://eprints.soton.ac.uk/id/eprint/427726
PURE UUID: abd0d869-42a2-462b-9b42-f993aa0b7a30

Catalogue record

Date deposited: 25 Jan 2019 17:30
Last modified: 13 Mar 2019 17:42

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