The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

The effect of vitamin D supplementation on hepcidin, iron status and inflammation in pregnant women in the United Kingdom

The effect of vitamin D supplementation on hepcidin, iron status and inflammation in pregnant women in the United Kingdom
The effect of vitamin D supplementation on hepcidin, iron status and inflammation in pregnant women in the United Kingdom
Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D3 supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)—a double-blinded, randomized, placebo-controlled trial (ISRCTN82927713; EudraCT2007-001716-23)—we performed a secondary laboratory analysis. Women with blood samples from early and late pregnancy (vitamin D3 (1000 IU/day from ~14 weeks gestation n = 93; placebo n = 102) who gave birth in the springtime (March–May) were selected as we anticipated seeing the greatest treatment group difference in change in 25-hydroxyvitamin D (25OHD) concentration. Outcomes were hepcidin, ferritin, C-reactive protein, and α1-acid glycoprotein concentration in late pregnancy (25OHD concentration was measured previously). By late pregnancy, 25OHD concentration increased by 17 nmol/L in the vitamin D3 group and decreased by 11 nmol/L in the placebo group; hepcidin, ferritin, and inflammatory markers decreased but no treatment group differences were seen. In late pregnancy, positive relationships between 25OHD and hepcidin and 25OHD and ferritin in the placebo group were observed but not in the treatment group (group × 25OHD interaction, p < 0.02). Vitamin D3 supplementation had no effect on hepcidin, ferritin, or inflammatory status suggesting no adjunctive value of vitamin D3 in reducing rates of antenatal iron deficiency.
Braithwaite, Vickie S.
d2ff9edb-bbc0-4d3f-a866-229158c36214
Crozier, Sarah
9c3595ce-45b0-44fa-8c4c-4c555e628a03
D'angelo, Stefania
13375ecd-1117-4b6e-99c0-32239f52eed6
Prentice, Ann
d4f64e9c-f9dd-4a22-9b6d-221faeaa0970
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Jones, Kerry S.
ce3206c4-c7d3-43b0-8f45-09a76a11d869
MAVIDOS Trial Group
Braithwaite, Vickie S.
d2ff9edb-bbc0-4d3f-a866-229158c36214
Crozier, Sarah
9c3595ce-45b0-44fa-8c4c-4c555e628a03
D'angelo, Stefania
13375ecd-1117-4b6e-99c0-32239f52eed6
Prentice, Ann
d4f64e9c-f9dd-4a22-9b6d-221faeaa0970
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Jones, Kerry S.
ce3206c4-c7d3-43b0-8f45-09a76a11d869

Braithwaite, Vickie S., Crozier, Sarah, D'angelo, Stefania, Prentice, Ann, Cooper, Cyrus, Harvey, Nicholas and Jones, Kerry S. , MAVIDOS Trial Group (2019) The effect of vitamin D supplementation on hepcidin, iron status and inflammation in pregnant women in the United Kingdom. Nutrients, 11 (1), [190]. (doi:10.3390/nu11010190).

Record type: Article

Abstract

Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D3 supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)—a double-blinded, randomized, placebo-controlled trial (ISRCTN82927713; EudraCT2007-001716-23)—we performed a secondary laboratory analysis. Women with blood samples from early and late pregnancy (vitamin D3 (1000 IU/day from ~14 weeks gestation n = 93; placebo n = 102) who gave birth in the springtime (March–May) were selected as we anticipated seeing the greatest treatment group difference in change in 25-hydroxyvitamin D (25OHD) concentration. Outcomes were hepcidin, ferritin, C-reactive protein, and α1-acid glycoprotein concentration in late pregnancy (25OHD concentration was measured previously). By late pregnancy, 25OHD concentration increased by 17 nmol/L in the vitamin D3 group and decreased by 11 nmol/L in the placebo group; hepcidin, ferritin, and inflammatory markers decreased but no treatment group differences were seen. In late pregnancy, positive relationships between 25OHD and hepcidin and 25OHD and ferritin in the placebo group were observed but not in the treatment group (group × 25OHD interaction, p < 0.02). Vitamin D3 supplementation had no effect on hepcidin, ferritin, or inflammatory status suggesting no adjunctive value of vitamin D3 in reducing rates of antenatal iron deficiency.

Text
Nutrients VB KJ v3 - Accepted Manuscript
Available under License Creative Commons Attribution.
Download (199kB)
Text
nutrients-11-00190 - Version of Record
Available under License Creative Commons Attribution.
Download (366kB)

More information

Accepted/In Press date: 14 January 2019
e-pub ahead of print date: 18 January 2019

Identifiers

Local EPrints ID: 427828
URI: http://eprints.soton.ac.uk/id/eprint/427828
PURE UUID: 08522fb2-c98c-43f5-a3cb-860a3386404a
ORCID for Sarah Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Stefania D'angelo: ORCID iD orcid.org/0000-0002-7267-1837
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 30 Jan 2019 17:30
Last modified: 26 Nov 2021 02:59

Export record

Altmetrics

Contributors

Author: Vickie S. Braithwaite
Author: Sarah Crozier ORCID iD
Author: Stefania D'angelo ORCID iD
Author: Ann Prentice
Author: Cyrus Cooper ORCID iD
Author: Nicholas Harvey ORCID iD
Author: Kerry S. Jones
Corporate Author: MAVIDOS Trial Group

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×