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The evaluation of the repeatability of the 13C-ketoisocaproate breath test for assessing hepatic mitochondrial function

The evaluation of the repeatability of the 13C-ketoisocaproate breath test for assessing hepatic mitochondrial function
The evaluation of the repeatability of the 13C-ketoisocaproate breath test for assessing hepatic mitochondrial function
The 13C-ketoisocaproate (13C-KICA) breath test (BT) has been recently proposed as a non-invasive test for assessing hepatic mitochondrial function. Results of the 13C-KICA BT can be expressed as different parameters. However, the best parameter for expressing the 13C-KICA BT result is uncertain which hinders use of the BT in routine clinical practice. We have investigated the repeatability of different parameters of 13C-KICA BT. Thirteen healthy adult subjects (5 men and 8 women) underwent a 13C-KICA BT on two occasions separated by a gap of approximately 30 days. There were no significant differences between the repeated measurements for all the test parameters over 30 days. Furthermore, the Bland Altman statistics showed no fixed or proportional bias for any of the test parameters. The cumulative 13C-dose enrichment over 60 min had the lowest within-subject variability of 12% compared to all other test parameters. The cumulative 13C-dose enrichment over 60 min could be a very useful parameter for the 13C-KICA BT to detect impaired hepatic mitochondrial function in patients with chronic liver diseases.
150-160
Afolabi, Paul
757e7f01-664c-493e-bc51-c6a2c933dc22
Scorletti, Eleonora
4e896544-2974-4f81-9696-1595d3c36814
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Afolabi, Paul
757e7f01-664c-493e-bc51-c6a2c933dc22
Scorletti, Eleonora
4e896544-2974-4f81-9696-1595d3c36814
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c

Afolabi, Paul, Scorletti, Eleonora, Calder, Philip and Byrne, Christopher (2019) The evaluation of the repeatability of the 13C-ketoisocaproate breath test for assessing hepatic mitochondrial function. Isotopes in Environmental and Health Studies, 55 (2), 150-160. (doi:10.1080/10256016.2019.1588265).

Record type: Article

Abstract

The 13C-ketoisocaproate (13C-KICA) breath test (BT) has been recently proposed as a non-invasive test for assessing hepatic mitochondrial function. Results of the 13C-KICA BT can be expressed as different parameters. However, the best parameter for expressing the 13C-KICA BT result is uncertain which hinders use of the BT in routine clinical practice. We have investigated the repeatability of different parameters of 13C-KICA BT. Thirteen healthy adult subjects (5 men and 8 women) underwent a 13C-KICA BT on two occasions separated by a gap of approximately 30 days. There were no significant differences between the repeated measurements for all the test parameters over 30 days. Furthermore, the Bland Altman statistics showed no fixed or proportional bias for any of the test parameters. The cumulative 13C-dose enrichment over 60 min had the lowest within-subject variability of 12% compared to all other test parameters. The cumulative 13C-dose enrichment over 60 min could be a very useful parameter for the 13C-KICA BT to detect impaired hepatic mitochondrial function in patients with chronic liver diseases.

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Accepted/In Press date: 22 January 2019
e-pub ahead of print date: 1 March 2019
Published date: 1 May 2019

Identifiers

Local EPrints ID: 427974
URI: https://eprints.soton.ac.uk/id/eprint/427974
PURE UUID: 81cbafc3-fa9f-4aab-aae6-b82895b0da31
ORCID for Paul Afolabi: ORCID iD orcid.org/0000-0002-0553-1578
ORCID for Christopher Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 06 Feb 2019 17:30
Last modified: 02 May 2019 00:37

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