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Investigation of the pentathiepin functionality as an Inhibitor of feline immunodeficiency virus (FIV) via a potential zinc ejection mechanism, as a model for HIV infection

Investigation of the pentathiepin functionality as an Inhibitor of feline immunodeficiency virus (FIV) via a potential zinc ejection mechanism, as a model for HIV infection
Investigation of the pentathiepin functionality as an Inhibitor of feline immunodeficiency virus (FIV) via a potential zinc ejection mechanism, as a model for HIV infection
A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
1,2,3,4,5-pentathiepin, FIV, HIV, Antiviral Agents, nucleocapsid protein, varacin
1860-7179
454-461
Asquith, Christopher R.M.
c00d3c3f-08c5-4c9a-bac8-0fc485db1be4
Laitinen, Tuomo
b37037c5-4eac-4533-8246-5a49213bae9b
Konstantinova, Lidia S.
39e4a58f-faa7-418d-ad88-5c5cb43d8d6f
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Poso, Antii
4563f55e-93b3-4df8-a5a6-1e75a4cd8455
Rakitin, Oleg A.
c13b5116-8058-4a48-aa7b-ef1feb737143
Hofmann-Lehmann, Regina
0c1c2056-848e-469c-8bb9-0258293160de
Hilton, Stephen T.
b3c15d45-c69d-47cd-a367-77a43e3fdbed
Asquith, Christopher R.M.
c00d3c3f-08c5-4c9a-bac8-0fc485db1be4
Laitinen, Tuomo
b37037c5-4eac-4533-8246-5a49213bae9b
Konstantinova, Lidia S.
39e4a58f-faa7-418d-ad88-5c5cb43d8d6f
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Poso, Antii
4563f55e-93b3-4df8-a5a6-1e75a4cd8455
Rakitin, Oleg A.
c13b5116-8058-4a48-aa7b-ef1feb737143
Hofmann-Lehmann, Regina
0c1c2056-848e-469c-8bb9-0258293160de
Hilton, Stephen T.
b3c15d45-c69d-47cd-a367-77a43e3fdbed

Asquith, Christopher R.M., Laitinen, Tuomo, Konstantinova, Lidia S., Tizzard, Graham J., Poso, Antii, Rakitin, Oleg A., Hofmann-Lehmann, Regina and Hilton, Stephen T. (2019) Investigation of the pentathiepin functionality as an Inhibitor of feline immunodeficiency virus (FIV) via a potential zinc ejection mechanism, as a model for HIV infection. ChemMedChem, 14 (4), 454-461. (doi:10.1002/cmdc.201800718).

Record type: Article

Abstract

A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.

Text
Penta-ChemMedChem 24thDec2018 CA Final - Accepted Manuscript
Restricted to Repository staff only until 3 January 2020.
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Text
Penta-ChemMedChem 24thDec2018 CA Final - Accepted Manuscript
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 3 January 2019
e-pub ahead of print date: 3 January 2019
Published date: 19 February 2019
Keywords: 1,2,3,4,5-pentathiepin, FIV, HIV, Antiviral Agents, nucleocapsid protein, varacin

Identifiers

Local EPrints ID: 427979
URI: https://eprints.soton.ac.uk/id/eprint/427979
ISSN: 1860-7179
PURE UUID: 2238b0b9-0d2c-4e9f-ae89-bfec57a4bf78
ORCID for Graham J. Tizzard: ORCID iD orcid.org/0000-0002-1577-5779

Catalogue record

Date deposited: 06 Feb 2019 17:30
Last modified: 23 Mar 2019 01:35

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Contributors

Author: Christopher R.M. Asquith
Author: Tuomo Laitinen
Author: Lidia S. Konstantinova
Author: Antii Poso
Author: Oleg A. Rakitin
Author: Regina Hofmann-Lehmann
Author: Stephen T. Hilton

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