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Early detection of abnormalities in partial epilepsy using magnetic resonance

Early detection of abnormalities in partial epilepsy using magnetic resonance
Early detection of abnormalities in partial epilepsy using magnetic resonance

The incidence of brain abnormalities determined by magnetic resonance in 30 consecutive children presenting with intractable complex partial seizures is reported. Images were optimised to visualise the hippocampus and cortical grey matter. Abnormalities of the hippocampus or temporal lobe were seen in all 19 children with clinical features of temporal lobe epilepsy and in six of the seven children with clinically unlocalised epilepsy. By contrast, in the four children with a clinical diagnosis of extratemporal epilepsy, no temporal or hippocampal abnormalities were seen. Generalised cortical abnormalities of uncertain significance were found in a total of 14 children from all groups. The identification of focal brain abnormalities using optimised magnetic resonance imaging enables early non-invasive assessment of children with intractable seizure disorders and the identification of patients for whom epilepsy surgery may be appropriate. It may also lead to a better understanding of the structural basis of intractable epilepsy, and thereby contribute to early treatment decisions.

0003-9888
104-109
Cross, J. H.
3c10596a-3f6e-418d-9957-8ec0a4e5078c
Jackson, G. D.
fcfdbe6b-0410-4492-a883-c52ef8b87763
Neville, B. G.R.
f955179d-844d-49cb-8d88-0eb6a1f76d8a
Connelly, A.
0cb19e67-b09d-458b-8c30-1e9f8a279887
Kirkham, F. J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Boyd, S. G.
16549366-4ac2-4d21-a11d-a070150d7742
Pitt, M. C.
4ce10041-6bb1-49fc-abbf-7d82ca60d6d2
Gadian, D. G.
2b0e526e-9bd0-4173-b5cd-ee32c8f66c57
Cross, J. H.
3c10596a-3f6e-418d-9957-8ec0a4e5078c
Jackson, G. D.
fcfdbe6b-0410-4492-a883-c52ef8b87763
Neville, B. G.R.
f955179d-844d-49cb-8d88-0eb6a1f76d8a
Connelly, A.
0cb19e67-b09d-458b-8c30-1e9f8a279887
Kirkham, F. J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Boyd, S. G.
16549366-4ac2-4d21-a11d-a070150d7742
Pitt, M. C.
4ce10041-6bb1-49fc-abbf-7d82ca60d6d2
Gadian, D. G.
2b0e526e-9bd0-4173-b5cd-ee32c8f66c57

Cross, J. H., Jackson, G. D., Neville, B. G.R., Connelly, A., Kirkham, F. J., Boyd, S. G., Pitt, M. C. and Gadian, D. G. (1993) Early detection of abnormalities in partial epilepsy using magnetic resonance. Archives of Disease in Childhood, 69 (1), 104-109. (doi:10.1136/adc.69.1.104).

Record type: Article

Abstract

The incidence of brain abnormalities determined by magnetic resonance in 30 consecutive children presenting with intractable complex partial seizures is reported. Images were optimised to visualise the hippocampus and cortical grey matter. Abnormalities of the hippocampus or temporal lobe were seen in all 19 children with clinical features of temporal lobe epilepsy and in six of the seven children with clinically unlocalised epilepsy. By contrast, in the four children with a clinical diagnosis of extratemporal epilepsy, no temporal or hippocampal abnormalities were seen. Generalised cortical abnormalities of uncertain significance were found in a total of 14 children from all groups. The identification of focal brain abnormalities using optimised magnetic resonance imaging enables early non-invasive assessment of children with intractable seizure disorders and the identification of patients for whom epilepsy surgery may be appropriate. It may also lead to a better understanding of the structural basis of intractable epilepsy, and thereby contribute to early treatment decisions.

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Published date: 1993

Identifiers

Local EPrints ID: 428117
URI: https://eprints.soton.ac.uk/id/eprint/428117
ISSN: 0003-9888
PURE UUID: f0d407c3-4d74-428f-bd90-824e81bff5a3

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Date deposited: 12 Feb 2019 17:30
Last modified: 12 Feb 2019 17:30

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Contributors

Author: J. H. Cross
Author: G. D. Jackson
Author: B. G.R. Neville
Author: A. Connelly
Author: F. J. Kirkham
Author: S. G. Boyd
Author: M. C. Pitt
Author: D. G. Gadian

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