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Catalyst-substrate effects on biocompatible SABRE hyperpolarization

Catalyst-substrate effects on biocompatible SABRE hyperpolarization
Catalyst-substrate effects on biocompatible SABRE hyperpolarization

The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.

biocompatibility, biomolecules, cytotoxicity, hyperpolarization, SABRE
1439-4235
285-294
Manoharan, Anand
ae3918f7-54d5-4321-9e41-18179b0052bf
Rayner, Peter J.
91603c52-4e8e-418c-b7d5-25cead3a8e49
Fekete, Marianna
0005fc12-f13f-46b3-9623-02abdd6f2c11
Iali, Wissam
74b43f75-005f-4d8a-b5b5-1b9aff3d2c13
Norcott, Philip
f6bbba8b-f5f2-4616-9e48-37fd3dd4bb80
Hugh Perry, V.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Duckett, Simon B.
f0cf4d7b-14f8-42cb-9117-0ffca9593652
Manoharan, Anand
ae3918f7-54d5-4321-9e41-18179b0052bf
Rayner, Peter J.
91603c52-4e8e-418c-b7d5-25cead3a8e49
Fekete, Marianna
0005fc12-f13f-46b3-9623-02abdd6f2c11
Iali, Wissam
74b43f75-005f-4d8a-b5b5-1b9aff3d2c13
Norcott, Philip
f6bbba8b-f5f2-4616-9e48-37fd3dd4bb80
Hugh Perry, V.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Duckett, Simon B.
f0cf4d7b-14f8-42cb-9117-0ffca9593652

Manoharan, Anand, Rayner, Peter J., Fekete, Marianna, Iali, Wissam, Norcott, Philip, Hugh Perry, V. and Duckett, Simon B. (2019) Catalyst-substrate effects on biocompatible SABRE hyperpolarization. ChemPhysChem, 20 (2), 285-294. (doi:10.1002/cphc.201800915).

Record type: Article

Abstract

The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.

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More information

Accepted/In Press date: 2018
e-pub ahead of print date: 5 November 2018
Published date: 21 January 2019
Keywords: biocompatibility, biomolecules, cytotoxicity, hyperpolarization, SABRE

Identifiers

Local EPrints ID: 428139
URI: https://eprints.soton.ac.uk/id/eprint/428139
ISSN: 1439-4235
PURE UUID: 4c0a5aba-7e56-4e48-99b0-49a26dc09785

Catalogue record

Date deposited: 12 Feb 2019 17:30
Last modified: 12 Feb 2019 17:30

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Contributors

Author: Anand Manoharan
Author: Peter J. Rayner
Author: Marianna Fekete
Author: Wissam Iali
Author: Philip Norcott
Author: V. Hugh Perry
Author: Simon B. Duckett

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