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Vitamin B6 in pediatric renal transplant recipients

Vitamin B6 in pediatric renal transplant recipients
Vitamin B6 in pediatric renal transplant recipients

Objectives: Our aim was to assess the vitamin B6 intake and biochemical status in a sample of children who have undergone renal transplantation. Methods: A prospective observational study was performed in 10 pediatric renal transplant recipients to determine their vitamin B6 status through dietary assessment and serum Pyridoxal 5′-phosphate (PLP) measurement. Results: Ten children (mean age of 11.9 years) had median serum PLP concentrations of 62.45 nmol/L (interquartile range ±83.40). Two children (20%) had values above the reference range, and none below. Mean vitamin B6 intake was 138.7% of reference nutrient intake (standard deviation ±35.2%). No children were in receipt of vitamin B6 supplementation. Conclusion: There is no previous literature on vitamin B6 status in children who have undergone renal transplantation. In adult transplant recipients, elevated serum PLP concentrations have been described and ascribed to possible excessive intakes. In this sample, no children appeared biochemically deficient, but 20% had elevated concentrations. Dietary intakes were not excessive, and no children reported oral Vitamin B6 supplementation. Exploration of vitamin B6 metabolism in this population is required.

1051-2276
Harmer, Matthew
7a64b86a-f985-4d22-9d35-94ace59fc202
Wootton, Stephen
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Gilbert, Rodney
c69c5b99-2a15-4502-acd8-36b254d42601
Anderson, Caroline
1af5a611-d726-47c1-ad29-aa90fac736db
Harmer, Matthew
7a64b86a-f985-4d22-9d35-94ace59fc202
Wootton, Stephen
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Gilbert, Rodney
c69c5b99-2a15-4502-acd8-36b254d42601
Anderson, Caroline
1af5a611-d726-47c1-ad29-aa90fac736db

Harmer, Matthew, Wootton, Stephen, Gilbert, Rodney and Anderson, Caroline (2018) Vitamin B6 in pediatric renal transplant recipients. Journal of Renal Nutrition. (doi:10.1053/j.jrn.2018.09.003).

Record type: Article

Abstract

Objectives: Our aim was to assess the vitamin B6 intake and biochemical status in a sample of children who have undergone renal transplantation. Methods: A prospective observational study was performed in 10 pediatric renal transplant recipients to determine their vitamin B6 status through dietary assessment and serum Pyridoxal 5′-phosphate (PLP) measurement. Results: Ten children (mean age of 11.9 years) had median serum PLP concentrations of 62.45 nmol/L (interquartile range ±83.40). Two children (20%) had values above the reference range, and none below. Mean vitamin B6 intake was 138.7% of reference nutrient intake (standard deviation ±35.2%). No children were in receipt of vitamin B6 supplementation. Conclusion: There is no previous literature on vitamin B6 status in children who have undergone renal transplantation. In adult transplant recipients, elevated serum PLP concentrations have been described and ascribed to possible excessive intakes. In this sample, no children appeared biochemically deficient, but 20% had elevated concentrations. Dietary intakes were not excessive, and no children reported oral Vitamin B6 supplementation. Exploration of vitamin B6 metabolism in this population is required.

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e-pub ahead of print date: 10 November 2018

Identifiers

Local EPrints ID: 428143
URI: http://eprints.soton.ac.uk/id/eprint/428143
ISSN: 1051-2276
PURE UUID: 15eff6b4-c8d1-4c14-84da-a9fb73d469f3
ORCID for Rodney Gilbert: ORCID iD orcid.org/0000-0001-7426-0188

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Date deposited: 12 Feb 2019 17:30
Last modified: 07 Oct 2020 02:20

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