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Clinical relevance of non-tuberculous mycobacteria isolated from respiratory specimens: seven year experience in a UK hospital

Clinical relevance of non-tuberculous mycobacteria isolated from respiratory specimens: seven year experience in a UK hospital
Clinical relevance of non-tuberculous mycobacteria isolated from respiratory specimens: seven year experience in a UK hospital

The frequency of isolation of non-tuberculous mycobacteria (NTM) species from respiratory specimens is increasing, however the clinical relevance of such identifications vary by mycobacterial species and geographical location. A retrospective study of 853 NTM isolates from respiratory samples from 386 patients over seven years was performed. Clinical records and radiographic information were examined. Clinical significance was assessed by American Thoracic Society diagnostic criteria. 25% of all patients with respiratory isolates met criteria for non-tuberculous mycobacterial pulmonary disease (NTM-PD). Significant symptoms were weight loss, fever, night sweats, productive cough and haemoptysis. HIV co-infection was a significant risk factor for disease. Cavities, nodules and tree-in-bud were significant radiographic findings. Mycobacterium avium complex (MAC) were the dominant species isolated from this patient cohort. Mycobacterium abscessus (M. abscessus) was the species most likely to cause clinically significant disease and be sputum smear positive, thus warranting particular attention.

2045-2322
1-6
Schiff, H.F.
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Jones, S.
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Achaiah, A.
dc506845-34d3-456f-9bf9-571f01626580
Pereira, A.
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Stait, G.
bc123f4c-e506-49db-aa50-b119ab9a3b7f
Green, B.
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Schiff, H.F.
0ceded73-f254-4a5e-b3f3-71fcbfdef35d
Jones, S.
a605e48d-b01d-40e1-a469-dc32dbc0e3e6
Achaiah, A.
dc506845-34d3-456f-9bf9-571f01626580
Pereira, A.
b2e13ee5-4593-4a8e-be2a-c2bb715b7cd8
Stait, G.
bc123f4c-e506-49db-aa50-b119ab9a3b7f
Green, B.
11aad629-bfdc-47a2-ba4a-343f3f7a52c5

Schiff, H.F., Jones, S., Achaiah, A., Pereira, A., Stait, G. and Green, B. (2019) Clinical relevance of non-tuberculous mycobacteria isolated from respiratory specimens: seven year experience in a UK hospital. Scientific Reports, 9 (1), 1-6. (doi:10.1038/s41598-018-37350-8).

Record type: Article

Abstract

The frequency of isolation of non-tuberculous mycobacteria (NTM) species from respiratory specimens is increasing, however the clinical relevance of such identifications vary by mycobacterial species and geographical location. A retrospective study of 853 NTM isolates from respiratory samples from 386 patients over seven years was performed. Clinical records and radiographic information were examined. Clinical significance was assessed by American Thoracic Society diagnostic criteria. 25% of all patients with respiratory isolates met criteria for non-tuberculous mycobacterial pulmonary disease (NTM-PD). Significant symptoms were weight loss, fever, night sweats, productive cough and haemoptysis. HIV co-infection was a significant risk factor for disease. Cavities, nodules and tree-in-bud were significant radiographic findings. Mycobacterium avium complex (MAC) were the dominant species isolated from this patient cohort. Mycobacterium abscessus (M. abscessus) was the species most likely to cause clinically significant disease and be sputum smear positive, thus warranting particular attention.

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Accepted/In Press date: 4 December 2018
e-pub ahead of print date: 11 February 2019

Identifiers

Local EPrints ID: 428250
URI: https://eprints.soton.ac.uk/id/eprint/428250
ISSN: 2045-2322
PURE UUID: dfbdb913-1287-4654-9a66-a2757899b8ab

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Date deposited: 19 Feb 2019 17:30
Last modified: 19 Jul 2019 16:41

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