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COSUTI: a protocol for the development of a core outcome set (COS) for interventions for the treatment of uncomplicated urinary tract infection (UTI) in adults

COSUTI: a protocol for the development of a core outcome set (COS) for interventions for the treatment of uncomplicated urinary tract infection (UTI) in adults
COSUTI: a protocol for the development of a core outcome set (COS) for interventions for the treatment of uncomplicated urinary tract infection (UTI) in adults

Background: Urinary tract infections (UTIs) are the second most common infection presenting in the community. Clinical guidelines and decision aids assist health practitioners to treat a UTI; however, treatment practices vary due to patient needs and context of presentation. Numerous trials have evaluated the effectiveness of treatment interventions for UTI; however, it is difficult to compare the results between trials due to inconsistencies between reported outcomes. Poor choice of outcome measures can lead to impairment of evidence synthesis due to the inability to compare outcomes between trials with similar aims. Transparency in selecting and reporting outcomes can be mitigated through the development of an agreed minimum set of outcomes that should be reported in clinical trials, referred to as a core outcome set (COS). This paper presents the protocol for the development of a COS for interventions in the treatment of uncomplicated UTI in adults. Methods: This COS development consists of three phases. Phase 1 is a systematic review, which aims to identify the core outcomes that have been reported in trials and systematic reviews of interventions treating uncomplicated UTI in adults. Phase 2 consists of a three-round online Delphi survey with stakeholders in the area of treatment interventions for UTI. The aim of this online Delphi survey is to achieve consensus on the importance of the outcomes emerging from Phase 1 of this research. Phase 3 is a consensus meeting to finalise the COS that should be reported in trials evaluating the effectiveness of interventions for the treatment of UTI. Discussion: It is hoped that the development of a COS for interventions for the treatment of uncomplicated UTI in adults will be adopted as a minimum set of outcomes that should be reported and measured within this context. If the findings from clinical trials related to treatment interventions for UTI are to impact on policy and practice, it is important that the findings from different treatment interventions are comparable across trials.

Core outcome set, Cystitis, Delphi survey, Systematic review, Urinary tract infections
1745-6215
1-6
Duane, Sinead
dbabeacb-6407-44fc-93ee-129293d65735
Vellinga, Akke
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Murphy, Andrew W.
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Cormican, Martin
ce3af423-4827-453d-94f7-2314008210ec
Smyth, Andrew
7fd9d79c-656a-4a70-a03a-40f5e4f7ac9d
Healy, Patricia
536b181b-c3bd-4f3d-b4a8-209ef62f9b15
Moore, Michael
1be81dad-7120-45f0-bbed-f3b0cc0cfe99
Little, Paul
1bf2d1f7-200c-47a5-ab16-fe5a8756a777
Devane, Declan
ac8af4dc-f7e3-40c3-9bfb-a269f6432109
Duane, Sinead
dbabeacb-6407-44fc-93ee-129293d65735
Vellinga, Akke
fcd10e9f-4b10-4084-a5fc-e0c05d920f72
Murphy, Andrew W.
ff64aee5-8cca-4015-bcf4-385f1f1dcd1e
Cormican, Martin
ce3af423-4827-453d-94f7-2314008210ec
Smyth, Andrew
7fd9d79c-656a-4a70-a03a-40f5e4f7ac9d
Healy, Patricia
536b181b-c3bd-4f3d-b4a8-209ef62f9b15
Moore, Michael
1be81dad-7120-45f0-bbed-f3b0cc0cfe99
Little, Paul
1bf2d1f7-200c-47a5-ab16-fe5a8756a777
Devane, Declan
ac8af4dc-f7e3-40c3-9bfb-a269f6432109

Duane, Sinead, Vellinga, Akke, Murphy, Andrew W., Cormican, Martin, Smyth, Andrew, Healy, Patricia, Moore, Michael, Little, Paul and Devane, Declan (2019) COSUTI: a protocol for the development of a core outcome set (COS) for interventions for the treatment of uncomplicated urinary tract infection (UTI) in adults. Trials, 20 (1), 1-6. (doi:10.1186/s13063-019-3194-x).

Record type: Article

Abstract

Background: Urinary tract infections (UTIs) are the second most common infection presenting in the community. Clinical guidelines and decision aids assist health practitioners to treat a UTI; however, treatment practices vary due to patient needs and context of presentation. Numerous trials have evaluated the effectiveness of treatment interventions for UTI; however, it is difficult to compare the results between trials due to inconsistencies between reported outcomes. Poor choice of outcome measures can lead to impairment of evidence synthesis due to the inability to compare outcomes between trials with similar aims. Transparency in selecting and reporting outcomes can be mitigated through the development of an agreed minimum set of outcomes that should be reported in clinical trials, referred to as a core outcome set (COS). This paper presents the protocol for the development of a COS for interventions in the treatment of uncomplicated UTI in adults. Methods: This COS development consists of three phases. Phase 1 is a systematic review, which aims to identify the core outcomes that have been reported in trials and systematic reviews of interventions treating uncomplicated UTI in adults. Phase 2 consists of a three-round online Delphi survey with stakeholders in the area of treatment interventions for UTI. The aim of this online Delphi survey is to achieve consensus on the importance of the outcomes emerging from Phase 1 of this research. Phase 3 is a consensus meeting to finalise the COS that should be reported in trials evaluating the effectiveness of interventions for the treatment of UTI. Discussion: It is hoped that the development of a COS for interventions for the treatment of uncomplicated UTI in adults will be adopted as a minimum set of outcomes that should be reported and measured within this context. If the findings from clinical trials related to treatment interventions for UTI are to impact on policy and practice, it is important that the findings from different treatment interventions are comparable across trials.

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Accepted/In Press date: 11 January 2019
Published date: 7 February 2019
Keywords: Core outcome set, Cystitis, Delphi survey, Systematic review, Urinary tract infections

Identifiers

Local EPrints ID: 428271
URI: https://eprints.soton.ac.uk/id/eprint/428271
ISSN: 1745-6215
PURE UUID: 381b4418-5f1f-4433-8af1-f6e716f419d1
ORCID for Michael Moore: ORCID iD orcid.org/0000-0002-5127-4509

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Date deposited: 20 Feb 2019 17:30
Last modified: 20 Jul 2019 00:57

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Contributors

Author: Sinead Duane
Author: Akke Vellinga
Author: Andrew W. Murphy
Author: Martin Cormican
Author: Andrew Smyth
Author: Patricia Healy
Author: Michael Moore ORCID iD
Author: Paul Little
Author: Declan Devane

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