Stockert roller pump generated pulsatile flow: Cerebral metabolic changes in adult cardiopulmonary bypass

Chow, Gabriel, Roberts, Iris G., Harris, David, Wilson, Jason, Elliott, Martin J., Edwards, A. David and Kirkham, Fenella J. (1997) Stockert roller pump generated pulsatile flow: Cerebral metabolic changes in adult cardiopulmonary bypass. Perfusion, 12 (2), 113-119.

Abstract

There is evidence that during cardiopulmonary bypass (CPB), pulsatile pump flow improves cerebral metabolism. This was a study to explore the effect of pulsatile versus nonpulsatile perfusion on cerebral lactate, pyruvate, glucose and β-hydroxybutyrate using a Stockert roller pump. We found no significant differences between the arterial-venous (A-V) differences of lactate, glucose and β-hydroxybutyrate (p > 0.05). When the upward trend of A-V pyruvate was accounted for, there was again no difference (p = 0.2). Arterial lactate:pyruvate ratios were not significantly different between pulsatile and nonpulsatile pump flow (p > 0.05). Venous lactate:pyruvate ratios were significantly higher during pulsatile bypass, but when the downward trend was accounted for, the differences between pulsatile and nonpulsatile values were no longer significant (p = 0.4). Therefore, the metabolic changes were not significant. There was no significant difference in systemic vascular resistance (SVR) during pulsatile and nonpulsatile flow (p = 0.4). Pulsatile flow delivered by the Stockert roller pump appears to have no metabolic or SVR advantages in adults undergoing CPB.

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Contributors

Author: Fenella J. Kirkham

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