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Stockert roller pump generated pulsatile flow: Cerebral metabolic changes in adult cardiopulmonary bypass

Stockert roller pump generated pulsatile flow: Cerebral metabolic changes in adult cardiopulmonary bypass
Stockert roller pump generated pulsatile flow: Cerebral metabolic changes in adult cardiopulmonary bypass

There is evidence that during cardiopulmonary bypass (CPB), pulsatile pump flow improves cerebral metabolism. This was a study to explore the effect of pulsatile versus nonpulsatile perfusion on cerebral lactate, pyruvate, glucose and β-hydroxybutyrate using a Stockert roller pump. We found no significant differences between the arterial-venous (A-V) differences of lactate, glucose and β-hydroxybutyrate (p > 0.05). When the upward trend of A-V pyruvate was accounted for, there was again no difference (p = 0.2). Arterial lactate:pyruvate ratios were not significantly different between pulsatile and nonpulsatile pump flow (p > 0.05). Venous lactate:pyruvate ratios were significantly higher during pulsatile bypass, but when the downward trend was accounted for, the differences between pulsatile and nonpulsatile values were no longer significant (p = 0.4). Therefore, the metabolic changes were not significant. There was no significant difference in systemic vascular resistance (SVR) during pulsatile and nonpulsatile flow (p = 0.4). Pulsatile flow delivered by the Stockert roller pump appears to have no metabolic or SVR advantages in adults undergoing CPB.

0267-6591
113-119
Chow, Gabriel
54191f58-cc39-493a-8eb5-98e0eedb213f
Roberts, Iris G.
9341326a-44f2-476b-97b9-847e506c51b8
Harris, David
232caafe-8ddb-4218-84d2-87e16a07ee91
Wilson, Jason
b059b9d8-7a1f-48c0-b35f-594da3b9f993
Elliott, Martin J.
b0a64acc-ed3a-48ff-b8b6-371276a5f80a
Edwards, A. David
221ff1ff-ee2c-4c16-b72e-5e84071dab29
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Chow, Gabriel
54191f58-cc39-493a-8eb5-98e0eedb213f
Roberts, Iris G.
9341326a-44f2-476b-97b9-847e506c51b8
Harris, David
232caafe-8ddb-4218-84d2-87e16a07ee91
Wilson, Jason
b059b9d8-7a1f-48c0-b35f-594da3b9f993
Elliott, Martin J.
b0a64acc-ed3a-48ff-b8b6-371276a5f80a
Edwards, A. David
221ff1ff-ee2c-4c16-b72e-5e84071dab29
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58

Chow, Gabriel, Roberts, Iris G., Harris, David, Wilson, Jason, Elliott, Martin J., Edwards, A. David and Kirkham, Fenella J. (1997) Stockert roller pump generated pulsatile flow: Cerebral metabolic changes in adult cardiopulmonary bypass. Perfusion, 12 (2), 113-119.

Record type: Article

Abstract

There is evidence that during cardiopulmonary bypass (CPB), pulsatile pump flow improves cerebral metabolism. This was a study to explore the effect of pulsatile versus nonpulsatile perfusion on cerebral lactate, pyruvate, glucose and β-hydroxybutyrate using a Stockert roller pump. We found no significant differences between the arterial-venous (A-V) differences of lactate, glucose and β-hydroxybutyrate (p > 0.05). When the upward trend of A-V pyruvate was accounted for, there was again no difference (p = 0.2). Arterial lactate:pyruvate ratios were not significantly different between pulsatile and nonpulsatile pump flow (p > 0.05). Venous lactate:pyruvate ratios were significantly higher during pulsatile bypass, but when the downward trend was accounted for, the differences between pulsatile and nonpulsatile values were no longer significant (p = 0.4). Therefore, the metabolic changes were not significant. There was no significant difference in systemic vascular resistance (SVR) during pulsatile and nonpulsatile flow (p = 0.4). Pulsatile flow delivered by the Stockert roller pump appears to have no metabolic or SVR advantages in adults undergoing CPB.

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Published date: 1997

Identifiers

Local EPrints ID: 428343
URI: https://eprints.soton.ac.uk/id/eprint/428343
ISSN: 0267-6591
PURE UUID: 701671e5-4abe-4e73-95a9-a6eff58642e5

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Date deposited: 21 Feb 2019 17:30
Last modified: 13 Mar 2019 17:34

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Contributors

Author: Gabriel Chow
Author: Iris G. Roberts
Author: David Harris
Author: Jason Wilson
Author: Martin J. Elliott
Author: A. David Edwards
Author: Fenella J. Kirkham

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