The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

The ME7 prion model of neurodegeneration as a tool to understand and target neuroinflammation in Alzheimer's disease

The ME7 prion model of neurodegeneration as a tool to understand and target neuroinflammation in Alzheimer's disease
The ME7 prion model of neurodegeneration as a tool to understand and target neuroinflammation in Alzheimer's disease

To develop disease-modifying therapies for Alzheimer's disease (AD), an understanding of the pathways that lead to synaptic damage and neuronal cell death is required. The ME7 prion mouse model shares hallmarks of human neurodegenerative diseases and has a well-defined disease progression that can be monitored non-invasively through changes in behaviour. In addition, a strong involvement of neuroinflammation in ME7 disease progression and systemic inflammatory challenge has provided rationale to study and target cytokines in human AD patients. Furthermore, susceptibility of the model to acute cognitive deficits generated a model of delirium has supported human dementia studies. Thus, the ME7 prion model provides a translatable model of neurodegeneration and neuroinflammation that could provide validation of potential treatments against the inflammatory response during neurodegeneration.

45-52
Chouhan, Joe K.
4468111f-65b2-4046-9860-70843616f83b
Fowler, Susan B.
fc32b58b-8a85-4d40-8471-d78a629876b4
Webster, Carl I.
44f49090-c4eb-440b-ae2c-6fe70f9188d6
Teeling, Jessica L.
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Chouhan, Joe K.
4468111f-65b2-4046-9860-70843616f83b
Fowler, Susan B.
fc32b58b-8a85-4d40-8471-d78a629876b4
Webster, Carl I.
44f49090-c4eb-440b-ae2c-6fe70f9188d6
Teeling, Jessica L.
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a

Chouhan, Joe K., Fowler, Susan B., Webster, Carl I. and Teeling, Jessica L. (2018) The ME7 prion model of neurodegeneration as a tool to understand and target neuroinflammation in Alzheimer's disease. Drug Discovery Today: Disease Models, 25-26, 45-52. (doi:10.1016/j.ddmod.2018.10.004).

Record type: Article

Abstract

To develop disease-modifying therapies for Alzheimer's disease (AD), an understanding of the pathways that lead to synaptic damage and neuronal cell death is required. The ME7 prion mouse model shares hallmarks of human neurodegenerative diseases and has a well-defined disease progression that can be monitored non-invasively through changes in behaviour. In addition, a strong involvement of neuroinflammation in ME7 disease progression and systemic inflammatory challenge has provided rationale to study and target cytokines in human AD patients. Furthermore, susceptibility of the model to acute cognitive deficits generated a model of delirium has supported human dementia studies. Thus, the ME7 prion model provides a translatable model of neurodegeneration and neuroinflammation that could provide validation of potential treatments against the inflammatory response during neurodegeneration.

This record has no associated files available for download.

More information

Accepted/In Press date: 29 October 2018
e-pub ahead of print date: 22 November 2018

Identifiers

Local EPrints ID: 428427
URI: http://eprints.soton.ac.uk/id/eprint/428427
PURE UUID: a8ee27cf-f8bc-4df8-b67a-7df9678d095f
ORCID for Jessica L. Teeling: ORCID iD orcid.org/0000-0003-4004-7391

Catalogue record

Date deposited: 22 Feb 2019 17:31
Last modified: 10 Nov 2021 03:12

Export record

Altmetrics

Contributors

Author: Joe K. Chouhan
Author: Susan B. Fowler
Author: Carl I. Webster

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×