The ME7 prion model of neurodegeneration as a tool to understand and target neuroinflammation in Alzheimer's disease
The ME7 prion model of neurodegeneration as a tool to understand and target neuroinflammation in Alzheimer's disease
To develop disease-modifying therapies for Alzheimer's disease (AD), an understanding of the pathways that lead to synaptic damage and neuronal cell death is required. The ME7 prion mouse model shares hallmarks of human neurodegenerative diseases and has a well-defined disease progression that can be monitored non-invasively through changes in behaviour. In addition, a strong involvement of neuroinflammation in ME7 disease progression and systemic inflammatory challenge has provided rationale to study and target cytokines in human AD patients. Furthermore, susceptibility of the model to acute cognitive deficits generated a model of delirium has supported human dementia studies. Thus, the ME7 prion model provides a translatable model of neurodegeneration and neuroinflammation that could provide validation of potential treatments against the inflammatory response during neurodegeneration.
45-52
Chouhan, Joe K.
4468111f-65b2-4046-9860-70843616f83b
Fowler, Susan B.
fc32b58b-8a85-4d40-8471-d78a629876b4
Webster, Carl I.
44f49090-c4eb-440b-ae2c-6fe70f9188d6
Teeling, Jessica L.
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Chouhan, Joe K.
4468111f-65b2-4046-9860-70843616f83b
Fowler, Susan B.
fc32b58b-8a85-4d40-8471-d78a629876b4
Webster, Carl I.
44f49090-c4eb-440b-ae2c-6fe70f9188d6
Teeling, Jessica L.
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Chouhan, Joe K., Fowler, Susan B., Webster, Carl I. and Teeling, Jessica L.
(2018)
The ME7 prion model of neurodegeneration as a tool to understand and target neuroinflammation in Alzheimer's disease.
Drug Discovery Today: Disease Models, 25-26, .
(doi:10.1016/j.ddmod.2018.10.004).
Abstract
To develop disease-modifying therapies for Alzheimer's disease (AD), an understanding of the pathways that lead to synaptic damage and neuronal cell death is required. The ME7 prion mouse model shares hallmarks of human neurodegenerative diseases and has a well-defined disease progression that can be monitored non-invasively through changes in behaviour. In addition, a strong involvement of neuroinflammation in ME7 disease progression and systemic inflammatory challenge has provided rationale to study and target cytokines in human AD patients. Furthermore, susceptibility of the model to acute cognitive deficits generated a model of delirium has supported human dementia studies. Thus, the ME7 prion model provides a translatable model of neurodegeneration and neuroinflammation that could provide validation of potential treatments against the inflammatory response during neurodegeneration.
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Accepted/In Press date: 29 October 2018
e-pub ahead of print date: 22 November 2018
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Local EPrints ID: 428427
URI: http://eprints.soton.ac.uk/id/eprint/428427
PURE UUID: a8ee27cf-f8bc-4df8-b67a-7df9678d095f
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Date deposited: 22 Feb 2019 17:31
Last modified: 18 Mar 2024 02:59
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Author:
Joe K. Chouhan
Author:
Susan B. Fowler
Author:
Carl I. Webster
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