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Effect of eccentric exercise with reduced muscle glycogen on plasma interleukin-6 and neuromuscular responses of musculus quadriceps femoris

Effect of eccentric exercise with reduced muscle glycogen on plasma interleukin-6 and neuromuscular responses of musculus quadriceps femoris
Effect of eccentric exercise with reduced muscle glycogen on plasma interleukin-6 and neuromuscular responses of musculus quadriceps femoris
Eccentric exercise can result in muscle damage and interleukin-6 (IL-6) secretion. Glycogen availability is a potent stimulator of IL-6 secretion. We examined effects of eccentric exercise in a low-glycogen state on neuromuscular function and plasma IL-6 secretion. Twelve active men (23 ± 4 yr, 179 ± 5 cm, 77 ± 10 kg, means ± SD) completed two downhill treadmill runs (gradient, -12%, 5 × 8 min; speed, 12.1 ± 1.1 km/h) with normal (NG) and reduced muscle glycogen (RG) in randomized order and at least 6 wk apart. Muscle glycogen was reduced using an established cycling protocol until exhaustion and dietary manipulation the evening before the morning run. Physiological responses were measured up to 48 h after the downhill runs. During recovery, force deficits of musculus quadriceps femoris by maximal isometric contractions were similar. Changes in low-frequency fatigue were larger with RG. Voluntary activation and plasma IL-6 levels were similar in recovery between conditions. It is concluded that unaccustomed, damaging eccentric exercise with low muscle glycogen of the m. quadriceps femoris 1) exacerbated low-frequency fatigue but 2) had no additional effect on IL-6 secretion. Neuromuscular impairment after eccentric exercise with low muscle glycogen appears to have a greater peripheral component in early recovery.
Adult, Exercise, Exercise Test, Fatigue, Glycogen, Humans, Interleukin-6, Isometric Contraction, Male, Quadriceps Muscle, Running, Young Adult, Journal Article
8750-7587
173-184
Gavin, James Peter
e0d9b404-3f63-4855-8e64-bf1692e6cc3f
Myers, Steve D
f1f200f5-f5b1-4eab-8542-4d435b50ed33
Willems, Marc E.T.
403242a2-7f54-4f8a-887d-d501ae5db0eb
Gavin, James Peter
e0d9b404-3f63-4855-8e64-bf1692e6cc3f
Myers, Steve D
f1f200f5-f5b1-4eab-8542-4d435b50ed33
Willems, Marc E.T.
403242a2-7f54-4f8a-887d-d501ae5db0eb

Gavin, James Peter, Myers, Steve D and Willems, Marc E.T. (2016) Effect of eccentric exercise with reduced muscle glycogen on plasma interleukin-6 and neuromuscular responses of musculus quadriceps femoris. Journal of Applied Physiology, 121 (1), 173-184. (doi:10.1152/japplphysiol.00383.2015).

Record type: Article

Abstract

Eccentric exercise can result in muscle damage and interleukin-6 (IL-6) secretion. Glycogen availability is a potent stimulator of IL-6 secretion. We examined effects of eccentric exercise in a low-glycogen state on neuromuscular function and plasma IL-6 secretion. Twelve active men (23 ± 4 yr, 179 ± 5 cm, 77 ± 10 kg, means ± SD) completed two downhill treadmill runs (gradient, -12%, 5 × 8 min; speed, 12.1 ± 1.1 km/h) with normal (NG) and reduced muscle glycogen (RG) in randomized order and at least 6 wk apart. Muscle glycogen was reduced using an established cycling protocol until exhaustion and dietary manipulation the evening before the morning run. Physiological responses were measured up to 48 h after the downhill runs. During recovery, force deficits of musculus quadriceps femoris by maximal isometric contractions were similar. Changes in low-frequency fatigue were larger with RG. Voluntary activation and plasma IL-6 levels were similar in recovery between conditions. It is concluded that unaccustomed, damaging eccentric exercise with low muscle glycogen of the m. quadriceps femoris 1) exacerbated low-frequency fatigue but 2) had no additional effect on IL-6 secretion. Neuromuscular impairment after eccentric exercise with low muscle glycogen appears to have a greater peripheral component in early recovery.

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Accepted/In Press date: 3 May 2016
e-pub ahead of print date: 6 July 2016
Published date: July 2016
Keywords: Adult, Exercise, Exercise Test, Fatigue, Glycogen, Humans, Interleukin-6, Isometric Contraction, Male, Quadriceps Muscle, Running, Young Adult, Journal Article

Identifiers

Local EPrints ID: 428430
URI: http://eprints.soton.ac.uk/id/eprint/428430
ISSN: 8750-7587
PURE UUID: bfec6963-4131-4a94-871b-cca1051f4a90
ORCID for James Peter Gavin: ORCID iD orcid.org/0000-0003-0574-0502

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Date deposited: 25 Feb 2019 17:30
Last modified: 22 Nov 2021 03:24

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Contributors

Author: Steve D Myers
Author: Marc E.T. Willems

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