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Relationships between ion channels, mitochondrial functions and inflammation in human aging

Relationships between ion channels, mitochondrial functions and inflammation in human aging
Relationships between ion channels, mitochondrial functions and inflammation in human aging
Aging is often associated with a loss of function. We believe aging to be more an adaptation to the various, and often continuous, stressors encountered during life in order to maintain overall functionality of the systems. The maladaptation of a system during aging may increase the susceptibility to diseases. There are basic cellular functions that may influence and/or are influenced by aging. Mitochondrial function is amongst these. Their presence in almost all cell types makes of these valuable targets for interventions to slow down or even reserve signs of aging. In this review, the role of mitochondria and essential physiological regulators of mitochondria and cellular functions, ion channels, will be discussed in the context of human aging. The origins of inflamm-aging, associated with poor clinical outcomes, will be linked to mitochondria and ion channel biology.
1664-042X
Strickland, Marie
b41f8585-f089-4712-9530-e2d239612e50
Yacoubi-Loueslati, Besma
cc84c855-5b08-4b98-ab79-239069b3e310
Bouhaouala-Zahar, Balkiss
d10f722d-5f91-41d1-b43e-efb2d75ce5db
Pender, Sylvia
62528b03-ec42-41bb-80fe-48454c2c5242
Larbi, Anis
0c559835-c23c-4694-aa2c-aa631ab1b2d3
Strickland, Marie
b41f8585-f089-4712-9530-e2d239612e50
Yacoubi-Loueslati, Besma
cc84c855-5b08-4b98-ab79-239069b3e310
Bouhaouala-Zahar, Balkiss
d10f722d-5f91-41d1-b43e-efb2d75ce5db
Pender, Sylvia
62528b03-ec42-41bb-80fe-48454c2c5242
Larbi, Anis
0c559835-c23c-4694-aa2c-aa631ab1b2d3

Strickland, Marie, Yacoubi-Loueslati, Besma, Bouhaouala-Zahar, Balkiss, Pender, Sylvia and Larbi, Anis (2019) Relationships between ion channels, mitochondrial functions and inflammation in human aging. Frontiers in Physiology, 10. (doi:10.3389/fphys.2019.00158).

Record type: Review

Abstract

Aging is often associated with a loss of function. We believe aging to be more an adaptation to the various, and often continuous, stressors encountered during life in order to maintain overall functionality of the systems. The maladaptation of a system during aging may increase the susceptibility to diseases. There are basic cellular functions that may influence and/or are influenced by aging. Mitochondrial function is amongst these. Their presence in almost all cell types makes of these valuable targets for interventions to slow down or even reserve signs of aging. In this review, the role of mitochondria and essential physiological regulators of mitochondria and cellular functions, ion channels, will be discussed in the context of human aging. The origins of inflamm-aging, associated with poor clinical outcomes, will be linked to mitochondria and ion channel biology.

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fphys-10-00158 - Version of Record
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Accepted/In Press date: 8 February 2019
Published date: 1 March 2019

Identifiers

Local EPrints ID: 428523
URI: https://eprints.soton.ac.uk/id/eprint/428523
ISSN: 1664-042X
PURE UUID: 283a1b33-87f4-45ca-b485-44662f10b2d2
ORCID for Sylvia Pender: ORCID iD orcid.org/0000-0001-6332-0333

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Date deposited: 01 Mar 2019 17:30
Last modified: 10 Dec 2019 01:48

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Contributors

Author: Marie Strickland
Author: Besma Yacoubi-Loueslati
Author: Balkiss Bouhaouala-Zahar
Author: Sylvia Pender ORCID iD
Author: Anis Larbi

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