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Genetic contribution to two special factors of neuroticism are associated with affluence

Genetic contribution to two special factors of neuroticism are associated with affluence
Genetic contribution to two special factors of neuroticism are associated with affluence
Neuroticism is a personality trait that describes the tendency to experience negative emotions. Individual differences in neuroticism are moderately stable across much of the life course; the trait is heritable, and higher levels are associated with psychiatric disorders, and have been estimated to have an economic burden to society greater than that of substance abuse, mood, or anxiety disorders. Understanding the genetic architecture of neuroticism therefore has the potential to offer insight into the causes of psychiatric disorders, general wellbeing, and longevity. The broad trait of neuroticism is composed of narrower traits, or factors. It was recently discovered that, whereas higher scores on the broad trait of neuroticism are associated with earlier death, higher scores on a worry/vulnerability factor are associated with living longer. Here, we examine the genetic architectures of two neuroticism factors, worry/vulnerability and anxiety/tension, and how they contrast with the architecture of the general factor of neuroticism. We show that, whereas the polygenic load for general factor of neuroticism is associated with an increased risk of coronary artery disease (CAD), major depressive disorder, and poorer self-rated health, the genetic variants associated with high levels of the anxiety/tension and worry/vulnerability factors are associated with affluence, higher cognitive ability, better self-rated health, and longer life. We also identify the first genes associated with factors of neuroticism that are linked with these positive outcomes that show no relationship with the general factor of neuroticism.
1359-4184
Hill, W David
0db96a02-aefa-4e10-b013-1a00eba51ac5
Weiss, Alexander
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Liewald, David C.
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Davies, Gail
1e979b2a-804f-4ba3-9c9b-519dd3a6b4be
Porteous, David J
7c036c8c-866c-42e6-87b6-5412dd120de7
Hayward, Caroline
8b58ae74-401a-4306-8b8f-c8414485131c
McIntosh, Andrew M.
126b1f77-19e2-4784-8a6a-6c537e6bd383
Gale, Catharine
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
Hill, W David
0db96a02-aefa-4e10-b013-1a00eba51ac5
Weiss, Alexander
c6f42bcd-c721-4862-9d31-7ee4598aa4d7
Liewald, David C.
80c48af9-1d7d-40bf-8995-f2a39f93ce3c
Davies, Gail
1e979b2a-804f-4ba3-9c9b-519dd3a6b4be
Porteous, David J
7c036c8c-866c-42e6-87b6-5412dd120de7
Hayward, Caroline
8b58ae74-401a-4306-8b8f-c8414485131c
McIntosh, Andrew M.
126b1f77-19e2-4784-8a6a-6c537e6bd383
Gale, Catharine
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac

Hill, W David, Weiss, Alexander, Liewald, David C., Davies, Gail, Porteous, David J, Hayward, Caroline, McIntosh, Andrew M., Gale, Catharine and Deary, Ian J. (2019) Genetic contribution to two special factors of neuroticism are associated with affluence. Molecular Psychiatry. (In Press)

Record type: Article

Abstract

Neuroticism is a personality trait that describes the tendency to experience negative emotions. Individual differences in neuroticism are moderately stable across much of the life course; the trait is heritable, and higher levels are associated with psychiatric disorders, and have been estimated to have an economic burden to society greater than that of substance abuse, mood, or anxiety disorders. Understanding the genetic architecture of neuroticism therefore has the potential to offer insight into the causes of psychiatric disorders, general wellbeing, and longevity. The broad trait of neuroticism is composed of narrower traits, or factors. It was recently discovered that, whereas higher scores on the broad trait of neuroticism are associated with earlier death, higher scores on a worry/vulnerability factor are associated with living longer. Here, we examine the genetic architectures of two neuroticism factors, worry/vulnerability and anxiety/tension, and how they contrast with the architecture of the general factor of neuroticism. We show that, whereas the polygenic load for general factor of neuroticism is associated with an increased risk of coronary artery disease (CAD), major depressive disorder, and poorer self-rated health, the genetic variants associated with high levels of the anxiety/tension and worry/vulnerability factors are associated with affluence, higher cognitive ability, better self-rated health, and longer life. We also identify the first genes associated with factors of neuroticism that are linked with these positive outcomes that show no relationship with the general factor of neuroticism.

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Accepted/In Press date: 22 February 2019

Identifiers

Local EPrints ID: 428689
URI: https://eprints.soton.ac.uk/id/eprint/428689
ISSN: 1359-4184
PURE UUID: a88ceb1a-9f9d-485f-aebe-67baa2c58402
ORCID for Catharine Gale: ORCID iD orcid.org/0000-0002-3361-8638

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Date deposited: 06 Mar 2019 17:30
Last modified: 11 Apr 2019 00:38

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Contributors

Author: W David Hill
Author: Alexander Weiss
Author: David C. Liewald
Author: Gail Davies
Author: David J Porteous
Author: Caroline Hayward
Author: Andrew M. McIntosh
Author: Catharine Gale ORCID iD
Author: Ian J. Deary

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