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Cohort profile: Design and methods in the eye and vision consortium of UK Biobank

Cohort profile: Design and methods in the eye and vision consortium of UK Biobank
Cohort profile: Design and methods in the eye and vision consortium of UK Biobank

Purpose To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. Participants UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, measurement of visual acuity, refractive error and keratometry, intraocular pressure (IOP), corneal biomechanics, spectral domain optical coherence tomography (OCT) of the macula and a disc-macula fundus photograph. Since recruitment, UK Biobank has collected accelerometer data and begun multimodal imaging data (including brain, heart and abdominal MRI) in 100 000 participants. Dense genotypic data and a panel of 20 biochemistry measures are available, and linkage to medical health records for the full cohort has begun. Findings to date A total of 502 665 people aged between 40 and 69 were recruited to participate in UK Biobank. Of these, 117 175 took part in baseline assessment of vision, IOP, refraction and keratometry. A subgroup of 67 321 underwent OCT and retinal photography. The introduction of eye and vision measures in UK Biobank was accompanied by intensive training, support and a data monitoring quality control process. Future plans UK Biobank is one of the largest prospective cohorts worldwide with extensive data on ophthalmic diseases and conditions. Data collection is an ongoing process and a repeat of the baseline assessment including the questionnaires, measurements and sample collection will be performed in subsets of 25 000 participants every 2-3 years. The depth and breadth of this dataset, coupled with its open-access policy, will create a powerful resource for all researchers to investigate the eye diseases in later life.

dementia, epidemiology, medical ophthalmology, medical retina
2044-6055
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Self, Jay
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UK Biobank Eye and Vision Consortium
Chua, Sharon Yu Lin
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Thomas, Dhanes
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Allen, Naomi
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Lotery, Andrew
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Desai, Parul
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Foster, Paul J.
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Zheng, Yalin
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Carare, Roxana O.
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Chan, Michelle
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Fruttiger, Marcus
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Lascaratos, Gerassimos
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Self, Jay
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Chua, Sharon Yu Lin, Thomas, Dhanes, Allen, Naomi, Lotery, Andrew, Desai, Parul, Patel, Praveen, Muthy, Zaynah, Sudlow, Cathie, Peto, Tunde, Khaw, Peng Tee, Foster, Paul J., Zheng, Yalin, Aslam, Tariq, Barman, Sarah A., Barrett, Jenny H., Bishop, Paul, Blows, Peter, Bunce, Catey, Carare, Roxana O., Chakravarthy, Usha, Chan, Michelle, Crabb, David P., Cumberland, Philippa M., Day, Alexander, Dhillon, Bal, Dick, Andrew D., Egan, Cathy, Ennis, Sarah, Fruttiger, Marcus, Gallacher, John E.J., Garway-Heath, David F., Gibson, Jane, Gore, Dan, Guggenheim, Jeremy A., Hammond, Chris J., Hardcastle, Alison, Harding, Simon P., Hogg, Ruth E., Hysi, Pirro, Keane, Pearse A., Khawaja, Anthony P., Lascaratos, Gerassimos, MacGillivray, Tom, Mackie, Sarah, Martin, Keith, McGaughey, Michelle, McGuinness, Bernadette, McKay, Gareth J., Morgan, James E. and Self, Jay , UK Biobank Eye and Vision Consortium (2019) Cohort profile: Design and methods in the eye and vision consortium of UK Biobank. BMJ Open, 9 (2). (doi:10.1136/bmjopen-2018-025077).

Record type: Review

Abstract

Purpose To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. Participants UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, measurement of visual acuity, refractive error and keratometry, intraocular pressure (IOP), corneal biomechanics, spectral domain optical coherence tomography (OCT) of the macula and a disc-macula fundus photograph. Since recruitment, UK Biobank has collected accelerometer data and begun multimodal imaging data (including brain, heart and abdominal MRI) in 100 000 participants. Dense genotypic data and a panel of 20 biochemistry measures are available, and linkage to medical health records for the full cohort has begun. Findings to date A total of 502 665 people aged between 40 and 69 were recruited to participate in UK Biobank. Of these, 117 175 took part in baseline assessment of vision, IOP, refraction and keratometry. A subgroup of 67 321 underwent OCT and retinal photography. The introduction of eye and vision measures in UK Biobank was accompanied by intensive training, support and a data monitoring quality control process. Future plans UK Biobank is one of the largest prospective cohorts worldwide with extensive data on ophthalmic diseases and conditions. Data collection is an ongoing process and a repeat of the baseline assessment including the questionnaires, measurements and sample collection will be performed in subsets of 25 000 participants every 2-3 years. The depth and breadth of this dataset, coupled with its open-access policy, will create a powerful resource for all researchers to investigate the eye diseases in later life.

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Accepted/In Press date: 11 December 2018
e-pub ahead of print date: 21 February 2019
Published date: 21 February 2019
Keywords: dementia, epidemiology, medical ophthalmology, medical retina

Identifiers

Local EPrints ID: 428945
URI: https://eprints.soton.ac.uk/id/eprint/428945
ISSN: 2044-6055
PURE UUID: 37ae9cc1-d7f8-420f-ade4-fb4b96ebfcaf
ORCID for Andrew Lotery: ORCID iD orcid.org/0000-0001-5541-4305
ORCID for Sarah Ennis: ORCID iD orcid.org/0000-0003-2648-0869
ORCID for Jane Gibson: ORCID iD orcid.org/0000-0002-0973-8285
ORCID for Jay Self: ORCID iD orcid.org/0000-0002-1030-9963

Catalogue record

Date deposited: 15 Mar 2019 17:30
Last modified: 20 Jul 2019 01:09

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Contributors

Author: Sharon Yu Lin Chua
Author: Dhanes Thomas
Author: Naomi Allen
Author: Andrew Lotery ORCID iD
Author: Parul Desai
Author: Praveen Patel
Author: Zaynah Muthy
Author: Cathie Sudlow
Author: Tunde Peto
Author: Peng Tee Khaw
Author: Paul J. Foster
Author: Yalin Zheng
Author: Tariq Aslam
Author: Sarah A. Barman
Author: Jenny H. Barrett
Author: Paul Bishop
Author: Peter Blows
Author: Catey Bunce
Author: Usha Chakravarthy
Author: Michelle Chan
Author: David P. Crabb
Author: Philippa M. Cumberland
Author: Alexander Day
Author: Bal Dhillon
Author: Andrew D. Dick
Author: Cathy Egan
Author: Sarah Ennis ORCID iD
Author: Marcus Fruttiger
Author: John E.J. Gallacher
Author: David F. Garway-Heath
Author: Jane Gibson ORCID iD
Author: Dan Gore
Author: Jeremy A. Guggenheim
Author: Chris J. Hammond
Author: Alison Hardcastle
Author: Simon P. Harding
Author: Ruth E. Hogg
Author: Pirro Hysi
Author: Pearse A. Keane
Author: Anthony P. Khawaja
Author: Gerassimos Lascaratos
Author: Tom MacGillivray
Author: Sarah Mackie
Author: Keith Martin
Author: Michelle McGaughey
Author: Bernadette McGuinness
Author: Gareth J. McKay
Author: James E. Morgan
Author: Jay Self ORCID iD

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