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Dynamic regulation of biosynthesis and trafficking of GABA(A) receptors

Dynamic regulation of biosynthesis and trafficking of GABA(A) receptors
Dynamic regulation of biosynthesis and trafficking of GABA(A) receptors

GABA(A) receptors are the major sites of fast synaptic inhibition in the central nervous system. To date 19 subunits have been identified (α1-6, β1-3, γ1-3, δ, ε, π, 6 and ρ 1-3). These subunits form heteropentamers usually consisting of two a, two β and one γ subunits. This review focuses on the description of the GABA(A) biosynthesis and trafficking to the cell membrane. The emphasis of this work lies on the multiple layers of regulation and control of GABA(A) receptors biosynthesis and trafficking. Abnormalities in these processes cause various disorders including schizophrenia, alcoholism and substance abuse, anxiety disorders and epilepsy. The review also points to the areas that require further investigation.

Endoplasmic reticulum, GABA(A) receptors, Golgi apparatus, RNA editing, Trafficking
0044-4677
292-303
Bogdanov, Y. D.
0c970999-e191-4f1b-90d9-7bf25a5d5b4b
Bogdanov, Y. D.
0c970999-e191-4f1b-90d9-7bf25a5d5b4b

Bogdanov, Y. D. (2018) Dynamic regulation of biosynthesis and trafficking of GABA(A) receptors. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, 68 (3), 292-303. (doi:10.7868/S0044467718030036).

Record type: Review

Abstract

GABA(A) receptors are the major sites of fast synaptic inhibition in the central nervous system. To date 19 subunits have been identified (α1-6, β1-3, γ1-3, δ, ε, π, 6 and ρ 1-3). These subunits form heteropentamers usually consisting of two a, two β and one γ subunits. This review focuses on the description of the GABA(A) biosynthesis and trafficking to the cell membrane. The emphasis of this work lies on the multiple layers of regulation and control of GABA(A) receptors biosynthesis and trafficking. Abnormalities in these processes cause various disorders including schizophrenia, alcoholism and substance abuse, anxiety disorders and epilepsy. The review also points to the areas that require further investigation.

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More information

Published date: 2018
Keywords: Endoplasmic reticulum, GABA(A) receptors, Golgi apparatus, RNA editing, Trafficking

Identifiers

Local EPrints ID: 428960
URI: http://eprints.soton.ac.uk/id/eprint/428960
ISSN: 0044-4677
PURE UUID: 221ecfe4-82a7-4397-88ed-a498eeafc234
ORCID for Y. D. Bogdanov: ORCID iD orcid.org/0000-0003-4667-5890

Catalogue record

Date deposited: 15 Mar 2019 17:30
Last modified: 20 Jul 2019 00:35

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