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Maternal obesity during pregnancy and lactation influences offspring obesogenic adipogenesis but not developmental adipogenesis in mice

Maternal obesity during pregnancy and lactation influences offspring obesogenic adipogenesis but not developmental adipogenesis in mice
Maternal obesity during pregnancy and lactation influences offspring obesogenic adipogenesis but not developmental adipogenesis in mice

Obesity is an escalating health crisis of pandemic proportions and by all accounts it has yet to reach its peak. Growing evidence suggests that obesity may have its origins in utero. Recent studies have shown that maternal obesity during pregnancy may promote adipogenesis in offspring. However, these studies were largely based on cell culture models. Whether or not maternal obesity impacts on offspring adipogenesis in vivo remains to be fully established. Furthermore, in vivo adipogenic differentiation has been shown to happen at distinct time periods, one during development (developmental adipogenesis-which is complete by 4 weeks of age in mice) and another in adulthood in response to feeding a high-fat (HF) diet (obesogenic adipogenesis). We therefore set out to determine whether maternal obesity impacted on offspring adipocyte hyperplasia in vivo and whether maternal obesity impacted on developmental or obesogenic adipogenesis, or both. Our findings reveal that maternal obesity is associated with enhanced obesogenic adipogenesis in HF-fed offspring. Interestingly, in newly weaned (4-week-old) offspring, maternal obesity is associated with adipocyte hypertrophy, but there were no changes in adipocyte number. Our results suggest that maternal obesity impacts on offspring obesogenic adipogenesis but does not affect developmental adipogenesis.

maternal obesity, nutrition, programming
Sellayah, Dyan
4b637ae6-a2f1-4eb6-8bd6-5155c58ac424
Thomas, Hugh
a5cd108c-a73e-47fc-8832-0c2c3f313199
Lanham, Stuart A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Cagampang, Felino R.
7cf57d52-4a65-4554-8306-ed65226bc50e
Sellayah, Dyan
4b637ae6-a2f1-4eb6-8bd6-5155c58ac424
Thomas, Hugh
a5cd108c-a73e-47fc-8832-0c2c3f313199
Lanham, Stuart A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Cagampang, Felino R.
7cf57d52-4a65-4554-8306-ed65226bc50e

Sellayah, Dyan, Thomas, Hugh, Lanham, Stuart A. and Cagampang, Felino R. (2019) Maternal obesity during pregnancy and lactation influences offspring obesogenic adipogenesis but not developmental adipogenesis in mice. Nutrients, 11 (3), [495]. (doi:10.3390/nu11030495).

Record type: Article

Abstract

Obesity is an escalating health crisis of pandemic proportions and by all accounts it has yet to reach its peak. Growing evidence suggests that obesity may have its origins in utero. Recent studies have shown that maternal obesity during pregnancy may promote adipogenesis in offspring. However, these studies were largely based on cell culture models. Whether or not maternal obesity impacts on offspring adipogenesis in vivo remains to be fully established. Furthermore, in vivo adipogenic differentiation has been shown to happen at distinct time periods, one during development (developmental adipogenesis-which is complete by 4 weeks of age in mice) and another in adulthood in response to feeding a high-fat (HF) diet (obesogenic adipogenesis). We therefore set out to determine whether maternal obesity impacted on offspring adipocyte hyperplasia in vivo and whether maternal obesity impacted on developmental or obesogenic adipogenesis, or both. Our findings reveal that maternal obesity is associated with enhanced obesogenic adipogenesis in HF-fed offspring. Interestingly, in newly weaned (4-week-old) offspring, maternal obesity is associated with adipocyte hypertrophy, but there were no changes in adipocyte number. Our results suggest that maternal obesity impacts on offspring obesogenic adipogenesis but does not affect developmental adipogenesis.

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nutrients-11-00495-v2-1 - Version of Record
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More information

Accepted/In Press date: 22 February 2019
e-pub ahead of print date: 27 February 2019
Published date: 27 February 2019
Keywords: maternal obesity, nutrition, programming

Identifiers

Local EPrints ID: 429048
URI: http://eprints.soton.ac.uk/id/eprint/429048
PURE UUID: 59d5cfaf-4d53-4e46-825b-88f56748c564
ORCID for Stuart A. Lanham: ORCID iD orcid.org/0000-0002-4516-264X
ORCID for Felino R. Cagampang: ORCID iD orcid.org/0000-0003-4404-9853

Catalogue record

Date deposited: 20 Mar 2019 17:30
Last modified: 26 Nov 2021 02:46

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Contributors

Author: Dyan Sellayah
Author: Hugh Thomas
Author: Stuart A. Lanham ORCID iD

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