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Nocturnal oxygen desaturation and disordered sleep as a potential factor in executive dysfunction in sickle cell anemia

Nocturnal oxygen desaturation and disordered sleep as a potential factor in executive dysfunction in sickle cell anemia
Nocturnal oxygen desaturation and disordered sleep as a potential factor in executive dysfunction in sickle cell anemia

Previous research has identified cognitive impairment in children with sickle cell anemia (SCA, Hemoglobin SS) compared with controls, partly accounted for by overt neuropathology after clinical stroke, covert (silent) infarction, and severity of anemia. However, cognitive deficits have also been identified in children with SCA with no history of stroke and a normal T2-weighted magnetic resonance imaging (MRI) scan. Our aim was to investigate whether nocturnal hemoglobin oxygen desaturation and sleep fragmentation could be associated with cognitive impairment in children with SCA. We assessed 10 children with SCA (9 with normal MRI) using neuropsychological measures of executive function. Cognitive assessment was immediately followed by overnight polysomnography to record nocturnal hemoglobin oxygen saturation and sleep arousals. Decreases in hemoglobin oxygen saturation and/or increased sleep arousals were associated with reduced performance on cognitive assessment. Nocturnal hemoglobin oxygen desaturation and sleep fragmentation may be a contributing factor to executive dysfunction in SCA.

Anemia, Intelligence, Neuropsychology, Oximetry, Polysomnography, Sickle cell, Sleep arousal disorders
1355-6177
168-173
Hollocks, Matthew J.
37782979-571e-4d5e-95a3-ca8380da6bf7
Kok, Tessa B.
f3c75bbe-fa52-4187-9ca9-53745e2fd9a3
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Gavlak, Johanna
15bfdfeb-374b-4108-86c8-ec0a1dade98e
Inusa, Baba P.
56c8a1e9-5d37-437b-a7f1-11b49501603a
Debaun, Michael R.
76559153-80c6-4642-bdf8-672a75570dfe
De Haan, Michelle
72c96996-93a0-4629-9c61-4efc7c6e697d
Hollocks, Matthew J.
37782979-571e-4d5e-95a3-ca8380da6bf7
Kok, Tessa B.
f3c75bbe-fa52-4187-9ca9-53745e2fd9a3
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Gavlak, Johanna
15bfdfeb-374b-4108-86c8-ec0a1dade98e
Inusa, Baba P.
56c8a1e9-5d37-437b-a7f1-11b49501603a
Debaun, Michael R.
76559153-80c6-4642-bdf8-672a75570dfe
De Haan, Michelle
72c96996-93a0-4629-9c61-4efc7c6e697d

Hollocks, Matthew J., Kok, Tessa B., Kirkham, Fenella J., Gavlak, Johanna, Inusa, Baba P., Debaun, Michael R. and De Haan, Michelle (2012) Nocturnal oxygen desaturation and disordered sleep as a potential factor in executive dysfunction in sickle cell anemia. Journal of the International Neuropsychological Society, 18 (1), 168-173. (doi:10.1017/S1355617711001469).

Record type: Article

Abstract

Previous research has identified cognitive impairment in children with sickle cell anemia (SCA, Hemoglobin SS) compared with controls, partly accounted for by overt neuropathology after clinical stroke, covert (silent) infarction, and severity of anemia. However, cognitive deficits have also been identified in children with SCA with no history of stroke and a normal T2-weighted magnetic resonance imaging (MRI) scan. Our aim was to investigate whether nocturnal hemoglobin oxygen desaturation and sleep fragmentation could be associated with cognitive impairment in children with SCA. We assessed 10 children with SCA (9 with normal MRI) using neuropsychological measures of executive function. Cognitive assessment was immediately followed by overnight polysomnography to record nocturnal hemoglobin oxygen saturation and sleep arousals. Decreases in hemoglobin oxygen saturation and/or increased sleep arousals were associated with reduced performance on cognitive assessment. Nocturnal hemoglobin oxygen desaturation and sleep fragmentation may be a contributing factor to executive dysfunction in SCA.

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More information

e-pub ahead of print date: 24 November 2011
Published date: January 2012
Keywords: Anemia, Intelligence, Neuropsychology, Oximetry, Polysomnography, Sickle cell, Sleep arousal disorders

Identifiers

Local EPrints ID: 429118
URI: http://eprints.soton.ac.uk/id/eprint/429118
ISSN: 1355-6177
PURE UUID: ddfb5456-2dab-4d7e-954e-d7b900bc4333
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 21 Mar 2019 17:30
Last modified: 23 Jul 2022 01:48

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Contributors

Author: Matthew J. Hollocks
Author: Tessa B. Kok
Author: Johanna Gavlak
Author: Baba P. Inusa
Author: Michael R. Debaun
Author: Michelle De Haan

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