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Transsylvian selective amygdalohippocampectomy in children with hippocampal sclerosis: Seizure, intellectual and memory outcome

Transsylvian selective amygdalohippocampectomy in children with hippocampal sclerosis: Seizure, intellectual and memory outcome
Transsylvian selective amygdalohippocampectomy in children with hippocampal sclerosis: Seizure, intellectual and memory outcome

Purpose: This study investigates the efficacy of transylvian selective amygdalohippocampectomy (TS SAH) in children with medically intractable epilepsy due to unilateral hippocampal sclerosis. Post-surgical seizure control, intellectual and memory outcomes are examined. Method: This study reports on pre- and post-surgical clinical data from 10 patients who underwent TS SAH between 2002 and 2010 after 24 months follow-up. Pre- and post-operative change in seizure frequency, AED use, intellect and memory are compared. Results: At 12 months and 24 months post-surgery, 9/10 (90%) and 7/8 (87.5%) patients respectively, were seizure free (Engel I). No patients were classed as Engel III or IV. No significant improvement or decline at a group level was found on measures of intellect or verbal or visual memory. One hundred per cent improved or remained within 1 SD of their pre-operatives score on verbal and perceptual reasoning learning and reasoning measures. Significant improvement was found post-operatively for both immediate and delayed facial memory. Conclusion: Our findings of good post-surgical seizure control and favourable cognitive outcome provides evidence against previous findings that SAH in children may not be effective.

Child, Epilepsy, Facial memory, Hippocampal sclerosis, Seizure, Transsylvian selective amygdalohippocampectomy
1059-1311
699-705
Beaton, Anne E.
1d11792c-b98b-4175-a4e6-51da9b60e20f
Durnford, Andrew
5b49b848-cf34-4024-9399-c342d71b09b6
Heffer-Rahn, Phillip E.
df3fc7bd-ec00-47c3-ab0a-9da35ad21df0
Kirkham, Fenella
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Griffin, Angela
3a36945e-1676-4064-a66d-5aad8787d23c
Gray, W. L.S.
91705c3a-19a4-43c6-ac63-91510dcb4cf2
Beaton, Anne E.
1d11792c-b98b-4175-a4e6-51da9b60e20f
Durnford, Andrew
5b49b848-cf34-4024-9399-c342d71b09b6
Heffer-Rahn, Phillip E.
df3fc7bd-ec00-47c3-ab0a-9da35ad21df0
Kirkham, Fenella
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Griffin, Angela
3a36945e-1676-4064-a66d-5aad8787d23c
Gray, W. L.S.
91705c3a-19a4-43c6-ac63-91510dcb4cf2

Beaton, Anne E., Durnford, Andrew, Heffer-Rahn, Phillip E., Kirkham, Fenella, Griffin, Angela and Gray, W. L.S. (2012) Transsylvian selective amygdalohippocampectomy in children with hippocampal sclerosis: Seizure, intellectual and memory outcome. Seizure, 21 (9), 699-705. (doi:10.1016/j.seizure.2012.07.012).

Record type: Article

Abstract

Purpose: This study investigates the efficacy of transylvian selective amygdalohippocampectomy (TS SAH) in children with medically intractable epilepsy due to unilateral hippocampal sclerosis. Post-surgical seizure control, intellectual and memory outcomes are examined. Method: This study reports on pre- and post-surgical clinical data from 10 patients who underwent TS SAH between 2002 and 2010 after 24 months follow-up. Pre- and post-operative change in seizure frequency, AED use, intellect and memory are compared. Results: At 12 months and 24 months post-surgery, 9/10 (90%) and 7/8 (87.5%) patients respectively, were seizure free (Engel I). No patients were classed as Engel III or IV. No significant improvement or decline at a group level was found on measures of intellect or verbal or visual memory. One hundred per cent improved or remained within 1 SD of their pre-operatives score on verbal and perceptual reasoning learning and reasoning measures. Significant improvement was found post-operatively for both immediate and delayed facial memory. Conclusion: Our findings of good post-surgical seizure control and favourable cognitive outcome provides evidence against previous findings that SAH in children may not be effective.

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More information

Published date: November 2012
Keywords: Child, Epilepsy, Facial memory, Hippocampal sclerosis, Seizure, Transsylvian selective amygdalohippocampectomy

Identifiers

Local EPrints ID: 429121
URI: https://eprints.soton.ac.uk/id/eprint/429121
ISSN: 1059-1311
PURE UUID: 03cbf20f-434c-4890-9608-dab41feb8ee4
ORCID for Fenella Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 21 Mar 2019 17:30
Last modified: 20 Jul 2019 01:05

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Contributors

Author: Anne E. Beaton
Author: Andrew Durnford
Author: Phillip E. Heffer-Rahn
Author: Fenella Kirkham ORCID iD
Author: Angela Griffin
Author: W. L.S. Gray

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