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Vibrotactile sensation and response to nifedipine dose titration in primary Raynaud's phenomenon

Vibrotactile sensation and response to nifedipine dose titration in primary Raynaud's phenomenon
Vibrotactile sensation and response to nifedipine dose titration in primary Raynaud's phenomenon

The clinical response to two doses of sustained-release nifedipine was assessed during a double-blind, randomized, placebo-controlled trial in 22 patients with primary Raynaud's phenomenon. Nifedipine at doses of 20 mg and 40 mg daily reduced the mean number of attacks by 40% compared with placebo with no significant differences between the two doses in the number of attacks or their severity. Unwanted effects were more common and more persistent with the higher dose of nifedipine. Fingertip vibrotactile thresholds measured at 31.5 and 125 Hz were unchanged by treatment with nifedipine. There was, however, a correlation between the pretreatment threshold at 125 Hz and the response to treatment with nifedipine, the most favorable responses occurring in patients with the lowest thresholds.

0003-3197
122-128
Challenor, V. F.
cad9de2d-2e15-46a0-8d40-48759c94fb7a
Waller, D. G.
1898f4f5-f141-4619-86fb-8597ce11429d
Hayward, R. A.
75d8a6ac-ff53-44a9-b2b5-21617a2d73a7
Griffin, M. J.
24112494-9774-40cb-91b7-5b4afe3c41b8
Roath, O. S.
68926379-b039-4b6f-a4ec-638dae0518d1
Challenor, V. F.
cad9de2d-2e15-46a0-8d40-48759c94fb7a
Waller, D. G.
1898f4f5-f141-4619-86fb-8597ce11429d
Hayward, R. A.
75d8a6ac-ff53-44a9-b2b5-21617a2d73a7
Griffin, M. J.
24112494-9774-40cb-91b7-5b4afe3c41b8
Roath, O. S.
68926379-b039-4b6f-a4ec-638dae0518d1

Challenor, V. F., Waller, D. G., Hayward, R. A., Griffin, M. J. and Roath, O. S. (1989) Vibrotactile sensation and response to nifedipine dose titration in primary Raynaud's phenomenon. Angiology, 40 (2), 122-128. (doi:10.1177/000331978904000207).

Record type: Article

Abstract

The clinical response to two doses of sustained-release nifedipine was assessed during a double-blind, randomized, placebo-controlled trial in 22 patients with primary Raynaud's phenomenon. Nifedipine at doses of 20 mg and 40 mg daily reduced the mean number of attacks by 40% compared with placebo with no significant differences between the two doses in the number of attacks or their severity. Unwanted effects were more common and more persistent with the higher dose of nifedipine. Fingertip vibrotactile thresholds measured at 31.5 and 125 Hz were unchanged by treatment with nifedipine. There was, however, a correlation between the pretreatment threshold at 125 Hz and the response to treatment with nifedipine, the most favorable responses occurring in patients with the lowest thresholds.

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Published date: 1 January 1989

Identifiers

Local EPrints ID: 429163
URI: http://eprints.soton.ac.uk/id/eprint/429163
ISSN: 0003-3197
PURE UUID: 9e2a08f0-de36-4258-808c-7b66de5dd719
ORCID for M. J. Griffin: ORCID iD orcid.org/0000-0003-0743-9502

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Date deposited: 22 Mar 2019 17:30
Last modified: 11 Mar 2021 17:37

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Contributors

Author: V. F. Challenor
Author: D. G. Waller
Author: R. A. Hayward
Author: M. J. Griffin ORCID iD
Author: O. S. Roath

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