Subjective and objective assessment of enalapril in primary Raynaud's phenomenon
Subjective and objective assessment of enalapril in primary Raynaud's phenomenon
1. The efficacy and acceptability of enalapril were assessed in a double‐blind, randomised, placebo controlled cross‐over study in 21 patients with primary Raynaud's phenomenon. 2. Skin temperature was assessed by thermocouples in response to a 15 degrees C cold water challenge as an index of digital blood flow. 3. Following enalapril there were no significant changes in the number and severity of Raynaud's attacks, and no subjective benefit from treatment as measured by visual analogue scales, 5 point rating scales, and skin temperature response to cold challenge when compared with placebo. 4. Enalapril in a dose of 20 mg daily is ineffective in the management of primary Raynaud's phenomenon. 1991 The British Pharmacological Society
477-480
Challenor, V.F.
cad9de2d-2e15-46a0-8d40-48759c94fb7a
Waller, D.G.
1898f4f5-f141-4619-86fb-8597ce11429d
Hayward, R.A.
75d8a6ac-ff53-44a9-b2b5-21617a2d73a7
Griffin, M.J.
24112494-9774-40cb-91b7-5b4afe3c41b8
Roath, O.S.
68926379-b039-4b6f-a4ec-638dae0518d1
1 April 1991
Challenor, V.F.
cad9de2d-2e15-46a0-8d40-48759c94fb7a
Waller, D.G.
1898f4f5-f141-4619-86fb-8597ce11429d
Hayward, R.A.
75d8a6ac-ff53-44a9-b2b5-21617a2d73a7
Griffin, M.J.
24112494-9774-40cb-91b7-5b4afe3c41b8
Roath, O.S.
68926379-b039-4b6f-a4ec-638dae0518d1
Challenor, V.F., Waller, D.G., Hayward, R.A., Griffin, M.J. and Roath, O.S.
(1991)
Subjective and objective assessment of enalapril in primary Raynaud's phenomenon.
British Journal of Clinical Pharmacology, 31 (4), .
(doi:10.1111/j.1365-2125.1991.tb05565.x).
Abstract
1. The efficacy and acceptability of enalapril were assessed in a double‐blind, randomised, placebo controlled cross‐over study in 21 patients with primary Raynaud's phenomenon. 2. Skin temperature was assessed by thermocouples in response to a 15 degrees C cold water challenge as an index of digital blood flow. 3. Following enalapril there were no significant changes in the number and severity of Raynaud's attacks, and no subjective benefit from treatment as measured by visual analogue scales, 5 point rating scales, and skin temperature response to cold challenge when compared with placebo. 4. Enalapril in a dose of 20 mg daily is ineffective in the management of primary Raynaud's phenomenon. 1991 The British Pharmacological Society
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Published date: 1 April 1991
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Local EPrints ID: 429167
URI: http://eprints.soton.ac.uk/id/eprint/429167
ISSN: 0306-5251
PURE UUID: f22080cd-9d78-42b4-ba2d-71aafd2560c7
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Date deposited: 22 Mar 2019 17:30
Last modified: 16 Mar 2024 00:54
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Author:
V.F. Challenor
Author:
D.G. Waller
Author:
R.A. Hayward
Author:
M.J. Griffin
Author:
O.S. Roath
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