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A systematic review of the effects of increasing arachidonic acid intake on PUFA status, metabolism and health-related outcomes in humans

A systematic review of the effects of increasing arachidonic acid intake on PUFA status, metabolism and health-related outcomes in humans
A systematic review of the effects of increasing arachidonic acid intake on PUFA status, metabolism and health-related outcomes in humans
We conducted a systematic review of randomised controlled trials (RCT) of increased intake of arachidonic acid (ARA) on fatty acid status and health outcomes in humans. We identified twenty-two articles from fourteen RCT. Most studies were conducted in adults. These used between 80 and 2000 mg ARA per d and were of 1–12 weeks duration. Supplementation with ARA doses as low as 80 mg/d increased the content of ARA in different blood fractions. Overall there seem to be few marked benefits for adults of increasing ARA intake from the typical usual intake of 100–200 mg/d to as much as 1000 mg/d; the few studies using higher doses (1500 or 2000 mg/d) also report little benefit. However, there may be an impact of ARA on cognitive and muscle function which could be particularly relevant in the ageing population. The studies reviewed here suggest no adverse effects in adults of increased ARA intake up to at least 1000–1500 mg/d on blood lipids, platelet aggregation and blood clotting, immune function, inflammation or urinary excretion of ARA metabolites. However, in many areas there are insufficient studies to make firm conclusions, and higher intakes of ARA are deserving of further study. Based on the RCT reviewed, there are not enough data to make any recommendations for specific health effects of ARA intake.
0007-1145
1201-1214
Calder, Philip
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Campoy, Cristina
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Eilander, Ans
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Fleith, Mathilde
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Forsyth, Stewart
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Larsson, Per-Olof
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Schelkle, Bettina
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Lohner, Szimonetta
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Szommer, Aliz
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van de Heijning, Bert J.M.
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Mensink, Ronald P.
68352ada-8d74-4d51-a1c6-ccf40a17c80c
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Campoy, Cristina
b9903745-882c-489b-8de0-7a8860e9b6be
Eilander, Ans
cbaeb9a6-51b9-48b8-b65c-9e0926cca474
Fleith, Mathilde
b423e973-89a4-44b3-a6d0-80065e6d21c7
Forsyth, Stewart
4b51b5e9-c0bb-44a2-865c-f94dc233ea15
Larsson, Per-Olof
d8087ec6-eebf-45f5-a421-709f2f1d6538
Schelkle, Bettina
79be8fe5-f2b7-487f-9b62-17fec23bee3e
Lohner, Szimonetta
194974b4-884d-4200-ad56-bcb3de725d1b
Szommer, Aliz
3a3372bd-6de8-42fe-a9c7-29dcc91ce775
van de Heijning, Bert J.M.
7426805d-494b-45ca-9398-22a72528c459
Mensink, Ronald P.
68352ada-8d74-4d51-a1c6-ccf40a17c80c

Calder, Philip, Campoy, Cristina, Eilander, Ans, Fleith, Mathilde, Forsyth, Stewart, Larsson, Per-Olof, Schelkle, Bettina, Lohner, Szimonetta, Szommer, Aliz, van de Heijning, Bert J.M. and Mensink, Ronald P. (2019) A systematic review of the effects of increasing arachidonic acid intake on PUFA status, metabolism and health-related outcomes in humans. British Journal of Nutrition, 121 (11), 1201-1214. (doi:10.1017/S0007114519000692).

Record type: Article

Abstract

We conducted a systematic review of randomised controlled trials (RCT) of increased intake of arachidonic acid (ARA) on fatty acid status and health outcomes in humans. We identified twenty-two articles from fourteen RCT. Most studies were conducted in adults. These used between 80 and 2000 mg ARA per d and were of 1–12 weeks duration. Supplementation with ARA doses as low as 80 mg/d increased the content of ARA in different blood fractions. Overall there seem to be few marked benefits for adults of increasing ARA intake from the typical usual intake of 100–200 mg/d to as much as 1000 mg/d; the few studies using higher doses (1500 or 2000 mg/d) also report little benefit. However, there may be an impact of ARA on cognitive and muscle function which could be particularly relevant in the ageing population. The studies reviewed here suggest no adverse effects in adults of increased ARA intake up to at least 1000–1500 mg/d on blood lipids, platelet aggregation and blood clotting, immune function, inflammation or urinary excretion of ARA metabolites. However, in many areas there are insufficient studies to make firm conclusions, and higher intakes of ARA are deserving of further study. Based on the RCT reviewed, there are not enough data to make any recommendations for specific health effects of ARA intake.

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ARA manuscript Final version Revised - Accepted Manuscript
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ARA paper Table 2 Revised - Accepted Manuscript
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ARA paper Figures Final - Accepted Manuscript
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Systematic review of the effects of increasing arachidonic acid intake on pufa status metabolism and health related outcomes in humans - Version of Record
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Accepted/In Press date: 13 March 2019
e-pub ahead of print date: 27 May 2019
Published date: 1 June 2019

Identifiers

Local EPrints ID: 429188
URI: https://eprints.soton.ac.uk/id/eprint/429188
ISSN: 0007-1145
PURE UUID: 17045bcf-64da-4e75-a4df-a1b9fc06eff9

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Date deposited: 22 Mar 2019 17:30
Last modified: 25 Jul 2019 16:30

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Contributors

Author: Philip Calder
Author: Cristina Campoy
Author: Ans Eilander
Author: Mathilde Fleith
Author: Stewart Forsyth
Author: Per-Olof Larsson
Author: Bettina Schelkle
Author: Szimonetta Lohner
Author: Aliz Szommer
Author: Bert J.M. van de Heijning
Author: Ronald P. Mensink

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