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Cortical abnormalities and language function in young patients with basal ganglia stroke

Cortical abnormalities and language function in young patients with basal ganglia stroke
Cortical abnormalities and language function in young patients with basal ganglia stroke

We examined MRI abnormalities and language function in young patients with infarctions apparently confined to the basal ganglia to establish whether impaired performance was attributable to basal ganglia damage per se or to additional cerebral abnormalities. Seventeen stroke patients (10 with left- and 7 with right-hemispheric damage) and seventeen controls participated. MRI included perfusion imaging and voxel-based morphometry analyses of T1-weighted and diffusion data sets. Language was assessed using the CELF-III test. Analysis of CELF-III scores showed a main effect of presence or absence of stroke, with patients performing more poorly than controls. There was no evidence of differences between the left- and right-hemisphere groups. However individual patients with left-hemisphere lesions showed large variations in performance. In the patients with left-hemisphere damage, voxel-based morphometry showed significant relationships between language function and gray matter density in cortical language areas. The white matter analyses also showed correlations with language function, and in addition there were hemodynamic abnormalities in cortical language areas in the three patients with poorest language function. We suggest that language impairments following basal ganglia damage may be attributable primarily to abnormalities in cortical language areas that are too subtle to detect on conventional structural MRI.

1053-8119
431-440
Rowan, Alison
04ef1a4c-7112-4226-b747-54dae2c5a50c
Vargha-Khadem, Faraneh
3093d3a3-f301-47d8-8192-4e1e8d832fed
Calamante, Fernando
63d493e7-04b6-4147-8353-5f487b994cab
Tournier, Jacques Donald
e8631c72-b9e0-4b47-94d6-1cdcaf74579d
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Chong, Wui K.
25419b0f-f3a0-4ece-a046-5bb05c279284
Baldeweg, Torsten
e6ba710f-1634-48fe-84b9-84141cc2ad54
Connelly, Alan
b2e15ed0-c70b-4de6-ab5a-4ff6861859de
Gadian, David G.
2b0e526e-9bd0-4173-b5cd-ee32c8f66c57
Rowan, Alison
04ef1a4c-7112-4226-b747-54dae2c5a50c
Vargha-Khadem, Faraneh
3093d3a3-f301-47d8-8192-4e1e8d832fed
Calamante, Fernando
63d493e7-04b6-4147-8353-5f487b994cab
Tournier, Jacques Donald
e8631c72-b9e0-4b47-94d6-1cdcaf74579d
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Chong, Wui K.
25419b0f-f3a0-4ece-a046-5bb05c279284
Baldeweg, Torsten
e6ba710f-1634-48fe-84b9-84141cc2ad54
Connelly, Alan
b2e15ed0-c70b-4de6-ab5a-4ff6861859de
Gadian, David G.
2b0e526e-9bd0-4173-b5cd-ee32c8f66c57

Rowan, Alison, Vargha-Khadem, Faraneh, Calamante, Fernando, Tournier, Jacques Donald, Kirkham, Fenella J., Chong, Wui K., Baldeweg, Torsten, Connelly, Alan and Gadian, David G. (2007) Cortical abnormalities and language function in young patients with basal ganglia stroke. NeuroImage, 36 (2), 431-440. (doi:10.1016/j.neuroimage.2007.02.051).

Record type: Article

Abstract

We examined MRI abnormalities and language function in young patients with infarctions apparently confined to the basal ganglia to establish whether impaired performance was attributable to basal ganglia damage per se or to additional cerebral abnormalities. Seventeen stroke patients (10 with left- and 7 with right-hemispheric damage) and seventeen controls participated. MRI included perfusion imaging and voxel-based morphometry analyses of T1-weighted and diffusion data sets. Language was assessed using the CELF-III test. Analysis of CELF-III scores showed a main effect of presence or absence of stroke, with patients performing more poorly than controls. There was no evidence of differences between the left- and right-hemisphere groups. However individual patients with left-hemisphere lesions showed large variations in performance. In the patients with left-hemisphere damage, voxel-based morphometry showed significant relationships between language function and gray matter density in cortical language areas. The white matter analyses also showed correlations with language function, and in addition there were hemodynamic abnormalities in cortical language areas in the three patients with poorest language function. We suggest that language impairments following basal ganglia damage may be attributable primarily to abnormalities in cortical language areas that are too subtle to detect on conventional structural MRI.

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Published date: June 2007

Identifiers

Local EPrints ID: 429371
URI: http://eprints.soton.ac.uk/id/eprint/429371
ISSN: 1053-8119
PURE UUID: c4a8cfe9-f39d-44b9-b295-1e584e3c5632
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 26 Mar 2019 17:30
Last modified: 18 Mar 2024 02:54

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Contributors

Author: Alison Rowan
Author: Faraneh Vargha-Khadem
Author: Fernando Calamante
Author: Jacques Donald Tournier
Author: Wui K. Chong
Author: Torsten Baldeweg
Author: Alan Connelly
Author: David G. Gadian

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